Zonulin Products
(Zonulin)
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As a result of hemolysis, hemoglobin is found to accumulate in the kidney and is secreted in the urine. Haptoglobin captures, and combines with free plasma hemoglobin to allow hepatic recycling of heme iron and to prevent kidney damage. Haptoglobin also acts as an antioxidant, has antibacterial activity, and plays a role in modulating many aspects of the acute phase response. Hemoglobin/haptoglobin complexes are rapidly cleared by the macrophage CD163 scavenger receptor expressed on the surface of liver Kupfer cells through an endocytic lysosomal degradation pathway. The uncleaved form of allele alpha-2 (2-2), known as zonulin, plays a role in intestinal permeability, allowing intercellular tight junction disassembly, and controlling the equilibrium between tolerance and immunity to non-self antigens. (UNIPROT)
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Recommended Zonulin Antibodies
Product
Reactivity
Application
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Human
Application
IHC (p), ELISA, EIA, IHC, IHC (fro)
Validations
- (1)
Cat. No.
ABIN165305
Quantity
100 μL
Datasheet
Datasheet
Recommended Zonulin ELISA Kits
Product
Reactivity
Analytical Method
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Human
Analytical Method
Quantitative Sandwich ELISA
Validations
- (8)
- (1)
Cat. No.
ABIN6962693
Quantity
96 tests
Datasheet
Datasheet
Reactivity
Human
Analytical Method
Quantitative Sandwich ELISA
Validations
- (2)
- (1)
Cat. No.
ABIN6974056
Quantity
96 tests
Datasheet
Datasheet
Latest Publications for our Zonulin products
: "Oxidative stress and gut-derived lipopolysaccharides in children affected by paediatric autoimmune neuropsychiatric disorders associated with streptococcal infections." in: BMC pediatrics, Vol. 20, Issue 1, pp. 127, (2021) (PubMed).: "Assessment of haptoglobin alleles in autism spectrum disorders." in: Scientific reports, Vol. 10, Issue 1, pp. 7758, (2020) (PubMed).
: "Oxidative Stress and Gut-Derived Lipopolysaccharides in Neurodegenerative Disease: Role of NOX2." in: Oxidative medicine and cellular longevity, Vol. 2020, pp. 8630275, (2020) (PubMed).
: "Could there be a role of serum zonulin increase in the development of hypercalcemia in primary hyperparathyroidism." in: Endocrine, (2020) (PubMed).
: "Increased Liver Localization of Lipopolysaccharides in Human and Experimental NAFLD." in: Hepatology (Baltimore, Md.), Vol. 72, Issue 2, pp. 470-485, (2020) (PubMed).
: "Intestinal Permeability in Children with Celiac Disease after the Administration of Oligofructose-Enriched Inulin into a Gluten-Free Diet-Results of a Randomized, Placebo-Controlled, Pilot Trial." in: Nutrients, Vol. 12, Issue 6, (2020) (PubMed).
: "Serum zonulin and claudin-5 levels in children with attention-deficit/hyperactivity disorder." in: International journal of psychiatry in clinical practice, pp. 1-7, (2020) (PubMed).
: "Localization of lipopolysaccharide from Escherichia Coli into human atherosclerotic plaque." in: Scientific reports, Vol. 8, Issue 1, pp. 3598, (2019) (PubMed).
: "Effects of long-term synbiotic supplementation in addition to lifestyle changes in children with obesity-related non-alcoholic fatty liver disease." in: The Turkish journal of gastroenterology : the official journal of Turkish Society of Gastroenterology, Vol. 28, Issue 5, pp. 377-383, (2018) (PubMed).
: "Are self-reported gastrointestinal symptoms among older adults associated with increased intestinal permeability and psychological distress?" in: BMC geriatrics, Vol. 18, Issue 1, pp. 75, (2018) (PubMed).
Synonyms and alternative names related to Zonulin
haptoglobin (HP), BP, HP2ALPHA2, HPA1SProtein level used designations for Zonulin
- binding peptide
- haptoglobin alpha(1S)-beta
- haptoglobin alpha(2FS)-beta
- haptoglobin, alpha polypeptide
- haptoglobin, beta polypeptide
- zonulin
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