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YWHAE Products

(14-3-3 epsilon (YWHAE))
This gene product belongs to the 14-3-3 family of proteins which mediate signal transduction by binding to phosphoserine-containing proteins. This highly conserved protein family is found in both plants and mammals, and this protein is 100% identical to the mouse ortholog. It interacts with CDC25 phosphatases, RAF1 and IRS1 proteins, suggesting its role in diverse biochemical activities related to signal transduction, such as cell division and regulation of insulin sensitivity. It has also been implicated in the pathogenesis of small cell lung cancer. Two transcript variants, one protein-coding and the other non-protein-coding, have been found for this gene. [provided by RefSeq, Aug 2008].

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Featured YWHAE Categories

YWHAE Antibodies

High quality antibodies with extensive validation data.

YWHAE ELISA Kits

Reliable ELISA kits for a wide range of species.

YWHAE Proteins

Proteins for various applications incl. WB, ELISA, IF etc.

Recommended YWHAE Antibodies

Product
Reactivity
Application
Validations
Cat. No.
Quantity
Datasheet
Reactivity Human
Application WB, ELISA, IHC, IF
Validations
  • (6)
Cat. No. ABIN7142087
Quantity 100 μg
Datasheet Datasheet
Reactivity Human
Application WB, IHC, StM
Validations
  • (4)
Cat. No. ABIN6940908
Quantity 100 μg
Datasheet Datasheet
Reactivity Human, Mouse, Rat
Application WB, ELISA, IHC, IF, ICC
Validations
  • (3)
Cat. No. ABIN6258570
Quantity 100 μL
Datasheet Datasheet

Recommended YWHAE ELISA Kits

Product
Reactivity
Analytical Method
Validations
Cat. No.
Quantity
Datasheet
Reactivity Human
Analytical Method Quantitative Sandwich ELISA
Validations
  • (1)
Cat. No. ABIN6960599
Quantity 96 tests
Datasheet Datasheet
Reactivity Human
Analytical Method Quantitative Sandwich ELISA
Validations
  • (1)
Cat. No. ABIN6976228
Quantity 96 tests
Datasheet Datasheet
Reactivity Human
Analytical Method Quantitative Sandwich ELISA
Validations
Cat. No. ABIN6730561
Quantity 96 tests
Datasheet Datasheet

Recommended YWHAE Proteins

Product
Reactivity
Source
Validations
Cat. No.
Quantity
Datasheet
Reactivity Human
Source Escherichia coli (E. coli)
Validations
  • (1)
Cat. No. ABIN7121596
Quantity 50 μg
Datasheet Datasheet
Reactivity Human
Source Wheat germ
Validations
  • (1)
Cat. No. ABIN1325544
Quantity 10 μg
Datasheet Datasheet
Reactivity Human
Source Escherichia coli (E. coli)
Validations
  • (1)
Cat. No. ABIN934949
Quantity 100 μg
Datasheet Datasheet

Latest Publications for our YWHAE products

OSullivan, Dowling, Joyce, McAuley, McCann, Henry, McGovern, Barham, Kelleher, Murphy, Kennedy, Swan, Moriarty, Clynes, Larkin: "A novel inhibitory anti-invasive MAb isolated using phenotypic screening highlights AnxA6 as a functionally relevant target protein in pancreatic cancer." in: British journal of cancer, Vol. 117, Issue 9, pp. 1326-1335, (2017) (PubMed).

Dowling, Moran, McAuley, Meleady, Henry, Clynes, McMenamin, Leonard, Monks, Wynne, Ormond, Larkin: "Quantitative label-free mass spectrometry analysis of formalin-fixed, paraffin-embedded tissue representing the invasive cutaneous malignant melanoma proteome." in: Oncology letters, Vol. 12, Issue 5, pp. 3296-3304, (2016) (PubMed).

Hu, Sun, Li, Wang, Cai, Li, Zhao: "In Ovo injection of betaine affects hepatic cholesterol metabolism through epigenetic gene regulation in newly hatched chicks." in: PLoS ONE, Vol. 10, Issue 4, pp. e0122643, (2016) (PubMed).

Dowling, Hughes, Larkin, Meiller, Henry, Meleady, Lynch, Pardini, Naccarati, Levy, Vodicka, Neary, Clynes: "Elevated levels of 14-3-3 proteins, serotonin, gamma enolase and pyruvate kinase identified in clinical samples from patients diagnosed with colorectal cancer." in: Clinica chimica acta; international journal of clinical chemistry, Vol. 441C, pp. 133-141, (2015) (PubMed).

Nagappan, Park, Park, Hong, Yumnam, Lee, Kim, Kim, Lee, Lee, Cho, Lee, Won, Cho, Kim: "Helicobacter pylori infection combined with DENA revealed altered expression of p53 and 14-3-3 isoforms in Gulo-/- mice." in: Chemico-biological interactions, Vol. 206, Issue 2, pp. 143-52, (2013) (PubMed).

Lee, Ou, Mariño-Enriquez, Zhu, Mayeda, Wang, Guo, Brunner, Amant, French, West, McAlpine, Gilks, Yaffe, Prentice, McPherson, Jones, Marra, Shah, van de Rijn, Huntsman, Dal Cin, Debiec-Rychter, Nucci et al.: "14-3-3 fusion oncogenes in high-grade endometrial stromal sarcoma. ..." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 109, Issue 3, pp. 929-34, (2012) (PubMed).

Wang, Nesland, Suo, Trope, Holm: "The prognostic value of 14-3-3 isoforms in vulvar squamous cell carcinoma cases: 14-3-3? and ? are independent prognostic factors for these tumors." in: PLoS ONE, Vol. 6, Issue 9, pp. e24843, (2011) (PubMed).

Tak, Jang, Kim, Park, Suk, Yoon, Ahn, Lee, Joe: "14-3-3epsilon inhibits MK5-mediated cell migration by disrupting F-actin polymerization." in: Cellular signalling, Vol. 19, Issue 11, pp. 2379-87, (2007) (PubMed).

Aitken: "14-3-3 proteins: a historic overview." in: Seminars in cancer biology, Vol. 16, Issue 3, pp. 162-72, (2006) (PubMed).

Urschel, Bassermann, Bai, Münch, Peschel, Duyster: "Phosphorylation of grb10 regulates its interaction with 14-3-3." in: The Journal of biological chemistry, Vol. 280, Issue 17, pp. 16987-93, (2005) (PubMed).

Synonyms and alternative names related to YWHAE

CG31196 gene product from transcript CG31196-RD (14-3-3epsilon), tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein epsilon (ywhae), 14-3-3 epsilon (LOC581376), 14-3-3 epsilon protein (Ywhae), 14-3-3 protein epsilon (HCAG_04173), 14-3-3 protein epsilon (PTRG_02836), 14-3-3 protein epsilon (PTRG_04459), 14-3-3 protein epsilon (UREG_07864), 14-3-3 protein epsilon (14-3-3epsilon), tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein epsilon (YWHAE), tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon polypeptide (YWHAE), tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon polypeptide (Ywhae), tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon (Ywhae), tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein epsilon S homeolog (ywhae.S), tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon polypeptide 1 (ywhae1), 14-3-3, 14-3-3 epsilon, 14-3-3-e, 14-3-3-epsilon, 14-3-3e, 14-3-3E, 14-3-3EPSILON, 14-3-3epsilon, 14-3-3omicron, 14-3-30epsilon, 143E_DROME, 1433epsilon, ACYPI002517, anon-WO0172774.141, anon-WO02059370.52, AU019196, CG31196, CT24092, D14-3-3e, D14-3-3epsilon, d14-3-3epsilon, Dmel\\CG31196, EK3-5, eps, fe38c12, kcip-1, KCIP-1, l(3)j2B10, LOC581376, mdcr, MDCR, mds, MDS, PAR-5, Par-5, par-5, PAR5, SR3-9, Su(Raf)3B, wu:fb48f06, wu:fe38c12, wu:fi22e10, Ywhae, YWHAE, ywhae, zgc:55377, zgc:77062

Protein level used designations for YWHAE

  • 14-3-3&epsilon
  • 14-3-3e
  • 14-3-3epsilon-PA
  • 14-3-3epsilon-PB
  • 14-3-3epsilon-PC
  • 14-3-3epsilon-PD
  • CG31196-PA
  • CG31196-PB
  • CG31196-PC
  • CG31196-PD
  • Tyrosine-3-monooxygenase
  • epsilon
  • suppressor of Ras85D 3-9
  • 14-3-3 epsilon
  • 14-3-3 epsilon protein
  • tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein epsilon polypeptide
  • 14-3-3 protein epsilon
  • tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon polypeptide
  • mitochondrial import stimulation factor L subunit
  • protein kinase C inhibitor protein-1
  • tyrosine 3/tryptophan 5 -monooxygenase activation protein, epsilon polypeptide
  • 14-3-3E
  • tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activatioprotein, epsilon polypeptide
  • MSF L
  • mitochondrial import stimulation factor (MSF) L subunit
  • tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activatioprotein epsilon polypeptide
  • 14-3-3 protein
  • 14-3-3epsilon
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