XRCC3 Products
(X-Ray Repair Complementing Defective Repair in Chinese Hamster Cells 3 (XRCC3))
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This gene encodes a member of the RecA/Rad51-related protein family that participates in homologous recombination to maintain chromosome stability and repair DNA damage. This gene functionally complements Chinese hamster irs1SF, a repair-deficient mutant that exhibits hypersensitivity to a number of different DNA-damaging agents and is chromosomally unstable. A rare microsatellite polymorphism in this gene is associated with cancer in patients of varying radiosensitivity. Alternatively spliced transcript variants encoding the same protein have been identified. [provided by RefSeq, Jul 2008].
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Featured XRCC3 Categories
XRCC3 Antibodies
High quality antibodies with extensive validation data.
XRCC3 Proteins
Proteins for various applications incl. WB, ELISA, IF etc.
Recommended XRCC3 Antibodies
Product
Reactivity
Application
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Human
Application
WB
Validations
- (2)
- (6)
Cat. No.
ABIN3023006
Quantity
100 μL
Datasheet
Datasheet
Reactivity
Human, Rat
Application
WB, ELISA, IHC, IF, ICC
Validations
- (4)
Cat. No.
ABIN6266068
Quantity
100 μL
Datasheet
Datasheet
Reactivity
Human
Application
WB, IP
Validations
- (4)
Cat. No.
ABIN521428
Quantity
100 μL
Datasheet
Datasheet
Recommended XRCC3 Proteins
Product
Reactivity
Source
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Human
Source
Wheat germ
Validations
- (1)
Cat. No.
ABIN1325467
Quantity
10 μg
Datasheet
Datasheet
Reactivity
Human
Source
Wheat germ
Validations
- (1)
Cat. No.
ABIN1325465
Quantity
10 μg
Datasheet
Datasheet
Reactivity
Human
Source
Escherichia coli (E. coli)
Validations
- (1)
Cat. No.
ABIN2132592
Quantity
100 μg
Datasheet
Datasheet
Latest Publications for our XRCC3 products
: "GCL and CUL3 Control the Switch between Cell Lineages by Mediating Localized Degradation of an RTK." in: Developmental cell, Vol. 42, Issue 2, pp. 130-142.e7, (2017) (PubMed).: "The transcription factor GATA3 is required for homologous recombination repair by regulating CtIP expression." in: Oncogene, Vol. 36, Issue 36, pp. 5168-5176, (2017) (PubMed).
: "NUCKS1 is a novel RAD51AP1 paralog important for homologous recombination and genome stability." in: Nucleic acids research, Vol. 43, Issue 20, pp. 9817-34, (2015) (PubMed).
: "A stress-induced cellular aging model with postnatal neural stem cells." in: Cell death & disease, Vol. 5, pp. e1116, (2014) (PubMed).
: "Breast cancer-associated missense mutants of the PALB2 WD40 domain, which directly binds RAD51C, RAD51 and BRCA2, disrupt DNA repair." in: Oncogene, Vol. 33, Issue 40, pp. 4803-12, (2014) (PubMed).
: "Systematic screen identifies miRNAs that target RAD51 and RAD51D to enhance chemosensitivity." in: Molecular cancer research : MCR, Vol. 11, Issue 12, pp. 1564-73, (2013) (PubMed).
: "Oxidative stress in mammalian cells impinges on the cysteines redox state of human XRCC3 protein and on its cellular localization." in: PLoS ONE, Vol. 8, Issue 10, pp. e75751, (2013) (PubMed).
: "Homologous recombination mediates S-phase-dependent radioresistance in cells deficient in DNA polymerase eta." in: Carcinogenesis, Vol. 33, Issue 11, pp. 2026-34, (2012) (PubMed).
: "Rad51 paralog complexes BCDX2 and CX3 act at different stages in the BRCA1-BRCA2-dependent homologous recombination pathway." in: Molecular and cellular biology, Vol. 33, Issue 2, pp. 387-95, (2012) (PubMed).
: "Discovery of a novel function for human Rad51: maintenance of the mitochondrial genome." in: The Journal of biological chemistry, Vol. 285, Issue 25, pp. 18984-90, (2010) (PubMed).
Synonyms and alternative names related to XRCC3
X-ray repair cross complementing 3 (XRCC3), X-ray repair complementing defective repair in Chinese hamster cells 3 (Xrcc3), X-ray repair complementing defective repair in Chinese hamster cells 3 L homeolog (xrcc3.L), X-ray repair complementing defective repair in Chinese hamster cells 3 (xrcc3), X-ray repair cross complementing 3 (Xrcc3), 4432412E01Rik, AI182522, AW537713, CMM6, im:7142103, MGC69118, si:dkey-11b8.1, xrcc3, XRCC3, zgc:101608Protein level used designations for XRCC3
- DNA repair protein XRCC3
- X-ray repair cross-complementing protein 3
- X-ray repair complementing defective repair in Chinese hamster cells 3
- DNA-repair protein XRCC3
- rCG27697-like
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