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XPO1 Products

(Exportin 1 (XPO1))

Categories

The protein encoded by this gene mediates leucine-rich nuclear export signal (NES)-dependent protein transport. Exportin 1 specifically inhibits the nuclear export of Rev and U snRNAs. It is involved in the control of several cellular processes by controlling the localization of cyclin B, MPAK, and MAPKAP kinase 2. This protein also regulates NFAT and AP-1. [provided by RefSeq, Jul 2008].

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Featured XPO1 Categories

XPO1 Antibodies

High quality antibodies with extensive validation data.

XPO1 ELISA Kits

Reliable ELISA kits for a wide range of species.

XPO1 Proteins

Proteins for various applications incl. WB, ELISA, IF etc.

Recommended XPO1 Antibodies

Product
Reactivity
Application
Validations
Cat. No.
Quantity
Datasheet
Reactivity Human, Mouse, Rat
Application WB, IHC (p), ICC
Validations
  • (7)
Cat. No. ABIN4886771
Quantity 100 μg
Datasheet Datasheet
Reactivity Human
Application WB, ELISA, IHC, IF
Validations
  • (4)
Cat. No. ABIN7152317
Quantity 100 μg
Datasheet Datasheet

Application WB, IHC
Validations
  • (1)
  • (4)
Cat. No. ABIN2778849
Quantity 100 μL
Datasheet Datasheet

Recommended XPO1 ELISA Kits

Product
Reactivity
Analytical Method
Validations
Cat. No.
Quantity
Datasheet
Reactivity Human
Analytical Method Quantitative Sandwich ELISA
Validations
  • (1)
  • (1)
Cat. No. ABIN6955675
Quantity 96 tests
Datasheet Datasheet
Reactivity Mouse
Analytical Method
Validations
Cat. No. ABIN1132695
Quantity 96 tests
Datasheet Datasheet
Reactivity Rat
Analytical Method
Validations
Cat. No. ABIN1132696
Quantity 96 tests
Datasheet Datasheet

Recommended XPO1 Proteins

Product
Reactivity
Source
Validations
Cat. No.
Quantity
Datasheet
Reactivity Human
Source Wheat germ
Validations
  • (1)
  • (1)
Cat. No. ABIN7477806
Quantity 2 μg
Datasheet Datasheet
Reactivity Human
Source Escherichia coli (E. coli)
Validations
Cat. No. ABIN7413031
Quantity 100 μg
Datasheet Datasheet
Reactivity Human
Source Tobacco (Nicotiana tabacum)
Validations
Cat. No. ABIN3096383
Quantity 1 mg
Datasheet Datasheet

Latest Publications for our XPO1 products

Kalita, Kapinos, Zheng, Rencurel, Zilman, Lim: "Karyopherin enrichment and compensation fortifies the nuclear pore complex against nucleocytoplasmic leakage." in: The Journal of cell biology, Vol. 221, Issue 3, (2022) (PubMed).

Seervi, Sumi, Chandrasekharan, Sharma, SanthoshKumar: "Molecular profiling of anastatic cancer cells: potential role of the nuclear export pathway." in: Cellular oncology (Dordrecht), Vol. 42, Issue 5, pp. 645-661, (2020) (PubMed).

Steyaert, Scheveneels, Vanneste, Van Damme, Robberecht, Callaerts, Bogaert, Van Den Bosch: "FUS-induced neurotoxicity in Drosophila is prevented by downregulating nucleocytoplasmic transport proteins." in: Human molecular genetics, Vol. 27, Issue 23, pp. 4103-4116, (2019) (PubMed).

García-Aguirre, Alamillo-Iniesta, Rodríguez-Pérez, Vélez-Aguilera, Amaro-Encarnación, Jiménez-Gutiérrez, Vásquez-Limeta, Samuel Laredo-Cisneros, Morales-Lázaro, Tiburcio-Félix, Ortega, Magaña, Winder et al.: "Enhanced nuclear protein export in premature aging and rescue of the progeria phenotype by modulation of CRM1 activity. ..." in: Aging cell, Vol. 18, Issue 5, pp. e13002, (2019) (PubMed).

Vélez-Aguilera, de Dios Gómez-López, Jiménez-Gutiérrez, Vásquez-Limeta, Laredo-Cisneros, Gómez, Winder, Cisneros: "Control of nuclear β-dystroglycan content is crucial for the maintenance of nuclear envelope integrity and function." in: Biochimica et biophysica acta. Molecular cell research, Vol. 1865, Issue 2, pp. 406-420, (2018) (PubMed).

Seipel, Marques, Bozzini, Meinken, Mueller, Pabst: "Inactivation of the p53-KLF4-CEBPA Axis in Acute Myeloid Leukemia." in: Clinical cancer research : an official journal of the American Association for Cancer Research, Vol. 22, Issue 3, pp. 746-56, (2016) (PubMed).

Oka, Mura, Yamada, Sangel, Hirata, Maehara, Kawakami, Tachibana, Ohkawa, Kimura, Yoneda: "Chromatin-prebound Crm1 recruits Nup98-HoxA9 fusion to induce aberrant expression of Hox cluster genes." in: eLife, Vol. 5, pp. e09540, (2016) (PubMed).

Vercruysse, De Bie, Neggers, Jacquemyn, Vanstreels, Schmid-Burgk, Hornung, Baloglu, Landesman, Senapedis, Shacham, Dagklis, Cools, Daelemans: "The second-generation exportin-1 inhibitor KPT-8602 demonstrates potent activity against acute lymphoblastic leukemia." in: Clinical cancer research : an official journal of the American Association for Cancer Research, (2016) (PubMed).

Bagheri, Badduke, Qiao, Colnaghi, Abramowicz, Alcantara, Dunham, Wen, Wildin, Nowaczyk, Eichmeyer, Lehman, Maranda, Martell, Shan, Lewis, ODriscoll, Gregory-Evans, Rajcan-Separovic: "Identifying candidate genes for 2p15p16.1 microdeletion syndrome using clinical, genomic, and functional analysis." in: JCI insight, Vol. 1, Issue 3, pp. e85461, (2016) (PubMed).

Sharma, Åkerström, Sharma, Chow, Teow, Abrenica, Booth, Booth, Mirazimi, Lal: "SARS-CoV 9b protein diffuses into nucleus, undergoes active Crm1 mediated nucleocytoplasmic export and triggers apoptosis when retained in the nucleus." in: PLoS ONE, Vol. 6, Issue 5, pp. e19436, (2011) (PubMed).

Synonyms and alternative names related to XPO1

embargoed (emb), exportin 1 (cgd3_3060), exportin 1 (Tc00.1047053511725.150), exportin 1 (Tb11.01.5940), exportin 1 (BBOV_II007220), putative exportin 1 (LMJF_32_1100), chromosome region maintenance protein 1 (xpo1), exportin 1 (Xpo1), exportin 1 (XPO1), exportin-1 (LOC100165622), exportin 1 (CRM1 homolog, yeast) (XPO1), exportin-1 (LOC100633509), exportin 1 S homeolog (xpo1.S), 18.m06600, AA420417, CG13387, CRM1, Crm1, crm1, DCRM1, dCRM1, DDBDRAFT_0183812, DDBDRAFT_0234066, DDB_0183812, DDB_0234066, Dmel\\CG13387, Emb, emb, exp1, Exp1, exportin-1, l(2)k16715, LOC100220104, Xpo, XPO-1, XPO1, Xpo1

Protein level used designations for XPO1

  • CG13387-PA
  • Exportin-1
  • chromosomal region maintenance 1
  • emb-PA
  • exportin
  • exportin 1
  • exportin-1
  • exportin 1 (CRM1 homolog, yeast)
  • exportin 1-like
  • exportin-1-like
  • CRM1, yeast, homolog
  • chromosome region maintenance 1 protein homolog
  • exportin 1 (CRM1, yeast, homolog)
  • exportin-1 (required for chromosome region maintenance)
  • nuclear export factor CRM1
  • CRM1/XPO1 protein
  • exp1
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