XPC Products
(Xeroderma Pigmentosum, Complementation Group C (XPC))
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This gene encodes a component of the nucleotide excision repair (NER) pathway. There are multiple components involved in the NER pathway, including Xeroderma pigmentosum (XP) A-G and V, Cockayne syndrome (CS) A and B, and trichothiodystrophy (TTD) group A, etc. This component, XPC, plays an important role in the early steps of global genome NER, especially in damage recognition, open complex formation, and repair protein complex formation. Mutations in this gene or some other NER components result in Xeroderma pigmentosum, a rare autosomal recessive disorder characterized by increased sensitivity to sunlight with the development of carcinomas at an early age. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Mar 2009].
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Featured XPC Categories
XPC Antibodies
High quality antibodies with extensive validation data.
XPC ELISA Kits
Reliable ELISA kits for a wide range of species.
XPC Proteins
Proteins for various applications incl. WB, ELISA, IF etc.
Recommended XPC Antibodies
Product
Reactivity
Application
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Human
Application
WB, ICC, IHC (p), IF
Validations
- (1)
- (3)
Cat. No.
ABIN2855495
Quantity
100 μL
Datasheet
Datasheet
Reactivity
Human
Application
WB, IHC, IP
Validations
- (1)
- (3)
Cat. No.
ABIN6150295
Quantity
100 μL
Datasheet
Datasheet
Reactivity
Human
Application
WB
Validations
- (1)
- (1)
Cat. No.
ABIN1882000
Quantity
400 μL
Datasheet
Datasheet
Recommended XPC ELISA Kits
Product
Reactivity
Analytical Method
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Human
Analytical Method
Quantitative Sandwich ELISA
Validations
- (1)
Cat. No.
ABIN6960580
Quantity
96 tests
Datasheet
Datasheet
Reactivity
Mouse
Analytical Method
Quantitative Sandwich ELISA
Validations
- (1)
Cat. No.
ABIN6960581
Quantity
96 tests
Datasheet
Datasheet
Reactivity
Human
Analytical Method
Quantitative Sandwich ELISA
Validations
Cat. No.
ABIN5660067
Quantity
96 tests
Datasheet
Datasheet
Recommended XPC Proteins
Product
Reactivity
Source
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Human
Source
Escherichia coli (E. coli)
Validations
- (1)
Cat. No.
ABIN7125751
Quantity
50 μg
Datasheet
Datasheet
Reactivity
Human
Source
Wheat germ
Validations
- (1)
Cat. No.
ABIN1325440
Quantity
10 μg
Datasheet
Datasheet
Reactivity
Mouse
Source
Escherichia coli (E. coli)
Validations
Cat. No.
ABIN7390589
Quantity
100 μg
Datasheet
Datasheet
Latest Publications for our XPC products
: "Commensal-Related Changes in the Epidermal Barrier Function Lead to Alterations in the Benzo[a]Pyrene Metabolite Profile and Its Distribution in 3D Skin." in: mBio, Vol. 12, Issue 5, pp. e0122321, (2022) (PubMed).: "Polynuclear ruthenium organometallic compounds induce DNA damage in human cells identified by the nucleotide excision repair factor XPC." in: Bioscience reports, Vol. 39, Issue 7, (2019) (PubMed).
: "Identification of four novel XPC mutations in two xeroderma pigmentosum complementation group C patients and functional study of XPC Q320X mutant." in: Gene, Vol. 628, pp. 162-169, (2017) (PubMed).
: "Role of DNA Repair Factor Xeroderma Pigmentosum Protein Group C in Response to Replication Stress As Revealed by DNA Fragile Site Affinity Chromatography and Quantitative Proteomics." in: Journal of proteome research, Vol. 15, Issue 12, pp. 4505-4517, (2016) (PubMed).
: "E2F1 responds to ultraviolet radiation by directly stimulating DNA repair and suppressing carcinogenesis." in: Cancer research, Vol. 74, Issue 12, pp. 3369-77, (2014) (PubMed).
: "Nucleotide excision repair activity on DNA damage induced by photoactivated methylene blue." in: Free radical biology & medicine, Vol. 61, pp. 343-56, (2014) (PubMed).
: "ATR pathway inhibition is synthetically lethal in cancer cells with ERCC1 deficiency." in: Cancer research, Vol. 74, Issue 10, pp. 2835-45, (2014) (PubMed).
: "Sodium arsenite ± hyperthermia sensitizes p53-expressing human ovarian cancer cells to cisplatin by modulating platinum-DNA damage responses." in: Toxicological sciences : an official journal of the Society of Toxicology, Vol. 127, Issue 1, pp. 139-49, (2012) (PubMed).
: "Downregulation of SWI/SNF chromatin remodeling factor subunits modulates cisplatin cytotoxicity." in: Experimental cell research, Vol. 318, Issue 16, pp. 1973-86, (2012) (PubMed).
: "Sodium arsenite and hyperthermia modulate cisplatin-DNA damage responses and enhance platinum accumulation in murine metastatic ovarian cancer xenograft after hyperthermic intraperitoneal ..." in: Journal of ovarian research, Vol. 4, pp. 9, (2011) (PubMed).
Synonyms and alternative names related to XPC
XPC complex subunit, DNA damage recognition and repair factor (XPC), xeroderma pigmentosum, complementation group C (Xpc), XPC complex subunit, DNA damage recognition and repair factor (Xpc), RAD4, XP3, XPCCProtein level used designations for XPC
- xeroderma pigmentosum, complementation group C
- DNA repair protein complementing XP-C cells
- mutant xeroderma pigmentosum group C
- p125
- DNA repair protein complementing XP-C cells homolog
- xeroderma pigmentosum group C-complementing protein homolog
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