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XPA Products

(Xeroderma Pigmentosum, Complementation Group A (XPA))

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This gene encodes a zinc finger protein involved in DNA excision repair. The encoded protein is part of the NER (nucleotide excision repair) complext which is responsible for repair of UV radiation-induced photoproducts and DNA adducts induced by chemical carcinogens. Mutations in this gene are associated with xeroderma pigmentosum complementation group A. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Mar 2009].

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Featured XPA Categories

XPA Antibodies

High quality antibodies with extensive validation data.

XPA ELISA Kits

Reliable ELISA kits for a wide range of species.

XPA Proteins

Proteins for various applications incl. WB, ELISA, IF etc.

Recommended XPA Antibodies

Product
Reactivity
Application
Validations
Cat. No.
Quantity
Datasheet
Reactivity Human
Application WB, IHC (p), IF, IP, ICC
Validations
  • (1)
  • (4)
Cat. No. ABIN2855566
Quantity 100 μL
Datasheet Datasheet
Reactivity Human
Application WB, ELISA, IF
Validations
  • (4)
Cat. No. ABIN948624
Quantity 100 μg
Datasheet Datasheet
Reactivity Human
Application WB, IHC (p), FACS
Validations
  • (3)
Cat. No. ABIN652730
Quantity 400 μL
Datasheet Datasheet

Recommended XPA ELISA Kits

Product
Reactivity
Analytical Method
Validations
Cat. No.
Quantity
Datasheet
Reactivity Human, Mouse
Analytical Method Qualitative Cell ELISA
Validations
Cat. No. ABIN1381596
Quantity 96 tests
Datasheet Datasheet

Recommended XPA Proteins

Product
Reactivity
Source
Validations
Cat. No.
Quantity
Datasheet
Reactivity Human
Source Wheat germ
Validations
  • (1)
Cat. No. ABIN1325438
Quantity 10 μg
Datasheet Datasheet
Reactivity Human
Source Escherichia coli (E. coli)
Validations
  • (1)
Cat. No. ABIN2132589
Quantity 100 μg
Datasheet Datasheet
Reactivity Human
Source Escherichia coli (E. coli)
Validations
Cat. No. ABIN1098757
Quantity 100 μg
Datasheet Datasheet

Latest Publications for our XPA products

Manandhar, Lowery, Boulware, Lin, Lu, Wood: "Transcriptional consequences of XPA disruption in human cell lines." in: DNA repair, Vol. 57, pp. 76-90, (2017) (PubMed).

Saquilabon Cruz, Kong, Silva, Khatibzadeh, Thai, Berns, Yokomori: "Femtosecond near-infrared laser microirradiation reveals a crucial role for PARP signaling on factor assemblies at DNA damage sites." in: Nucleic acids research, Vol. 44, Issue 3, pp. e27, (2016) (PubMed).

ODowd, Zavala, Brown, Mori, Fortunato: "HCMV-infected cells maintain efficient nucleotide excision repair of the viral genome while abrogating repair of the host genome." in: PLoS pathogens, Vol. 8, Issue 11, pp. e1003038, (2012) (PubMed).

Saijo, Matsuda, Kuraoka, Tanaka: "Inhibition of nucleotide excision repair by anti-XPA monoclonal antibodies which interfere with binding to RPA, ERCC1, and TFIIH." in: Biochemical and biophysical research communications, Vol. 321, Issue 4, pp. 815-22, (2004) (PubMed).

Araújo, Nigg, Wood: "Strong functional interactions of TFIIH with XPC and XPG in human DNA nucleotide excision repair, without a preassembled repairosome." in: Molecular and cellular biology, Vol. 21, Issue 7, pp. 2281-91, (2001) (PubMed).

Evans, Fellows, Coffer, Wood: "Open complex formation around a lesion during nucleotide excision repair provides a structure for cleavage by human XPG protein." in: The EMBO journal, Vol. 16, Issue 3, pp. 625-38, (1997) (PubMed).

Aboussekhra, Biggerstaff, Shivji, Vilpo, Moncollin, Podust, Protić, Hübscher, Egly, Wood: "Mammalian DNA nucleotide excision repair reconstituted with purified protein components." in: Cell, Vol. 80, Issue 6, pp. 859-68, (1995) (PubMed).

Tanaka, Miura, Satokata, Miyamoto, Yoshida, Satoh, Kondo, Yasui, Okayama, Okada: "Analysis of a human DNA excision repair gene involved in group A xeroderma pigmentosum and containing a zinc-finger domain." in: Nature, Vol. 348, Issue 6296, pp. 73-6, (1990) (PubMed).

Synonyms and alternative names related to XPA

Xeroderma pigmentosum group A-like (Xpac), XPA, DNA damage recognition and repair factor (XPA), xeroderma pigmentosum, complementation group A (Xpa), XPA, DNA damage recognition and repair factor (Xpa), xeroderma pigmentosum, complementation group A L homeolog (xpa.L), AI573865, CG6358, DhR14, DhXPA, Dmel\\CG6358, DmXPA, dmXPA, Dxpa, dxpa, EG:EG0007.8, XP1, Xpa, XPAC, Xpac, xpac, XPA_DROME, xxpa

Protein level used designations for XPA

  • CG6358-PA
  • Xpac-PA
  • xeroderma pigmentosum group A-like
  • DNA repair protein complementing XP-A cells
  • excision repair-controlling
  • xeroderma pigmentosum group A-complementing protein
  • DNA repair protein complementing XP-A cells homolog
  • xeroderma pigmentosum group A-complementing protein homolog
  • xpacch protein
  • xpacx1 protein
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