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XBP1 Products

(X-Box Binding Protein 1 (XBP1))

Categories

This gene encodes a transcription factor that regulates MHC class II genes by binding to a promoter element referred to as an X box. This gene product is a bZIP protein, which was also identified as a cellular transcription factor that binds to an enhancer in the promoter of the T cell leukemia virus type 1 promoter. It may increase expression of viral proteins by acting as the DNA binding partner of a viral transactivator. It has been found that upon accumulation of unfolded proteins in the endoplasmic reticulum (ER), the mRNA of this gene is processed to an active form by an unconventional splicing mechanism that is mediated by the endonuclease inositol-requiring enzyme 1 (IRE1). The resulting loss of 26 nt from the spliced mRNA causes a frame-shift and an isoform XBP1(S), which is the functionally active transcription factor. The isoform encoded by the unspliced mRNA, XBP1(U), is constitutively expressed, and thought to function as a negative feedback regulator of XBP1(S), which shuts off transcription of target genes during the recovery phase of ER stress. A pseudogene of XBP1 has been identified and localized to chromosome 5. [provided by RefSeq, Jul 2008].

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Featured XBP1 Categories

XBP1 Antibodies

High quality antibodies with extensive validation data.

XBP1 ELISA Kits

Reliable ELISA kits for a wide range of species.

XBP1 Proteins

Proteins for various applications incl. WB, ELISA, IF etc.

Recommended XBP1 Antibodies

Product
Reactivity
Application
Validations
Cat. No.
Quantity
Datasheet
Reactivity Human
Application WB, IF, IHC (p), ICC
Validations
  • (5)
Cat. No. ABIN2855334
Quantity 100 μL
Datasheet Datasheet
Reactivity Human
Application WB, IHC
Validations
  • (5)
Cat. No. ABIN7271399
Quantity 100 μL
Datasheet Datasheet
Reactivity Human
Application WB, ELISA, IHC, FACS
Validations
  • (6)
Cat. No. ABIN3029642
Quantity 0.4 mL
Datasheet Datasheet

Recommended XBP1 ELISA Kits

Product
Reactivity
Analytical Method
Validations
Cat. No.
Quantity
Datasheet
Reactivity Human
Analytical Method Quantitative Sandwich ELISA
Validations
  • (1)
Cat. No. ABIN6971207
Quantity 96 tests
Datasheet Datasheet
Reactivity Human
Analytical Method Quantitative Sandwich ELISA
Validations
  • (1)
Cat. No. ABIN6960567
Quantity 96 tests
Datasheet Datasheet
Reactivity Mouse
Analytical Method Quantitative Sandwich ELISA
Validations
  • (1)
Cat. No. ABIN6960568
Quantity 96 tests
Datasheet Datasheet

Recommended XBP1 Proteins

Product
Reactivity
Source
Validations
Cat. No.
Quantity
Datasheet
Reactivity Human
Source Wheat germ
Validations
  • (1)
Cat. No. ABIN1325428
Quantity 25 μg
Datasheet Datasheet
Reactivity Rat
Source Escherichia coli (E. coli)
Validations
Cat. No. ABIN7413280
Quantity 100 μg
Datasheet Datasheet
Reactivity Mouse
Source Escherichia coli (E. coli)
Validations
Cat. No. ABIN7396589
Quantity 100 μg
Datasheet Datasheet

Latest Publications for our XBP1 products

Zhang, Zhong, Sun, Sun, Zhou: "Hepatic overproduction of 13-HODE due to ALOX15 upregulation contributes to alcohol-induced liver injury in mice." in: Scientific reports, Vol. 7, Issue 1, pp. 8976, (2019) (PubMed).

Ma, Bi, Lu, Su, Huang, Liu, Wang, Yang, Kalady, Qian, Zhang, Gupte, Hamilton, Zheng, Yi: "Cholesterol Induces CD8+ T Cell Exhaustion in the Tumor Microenvironment." in: Cell metabolism, Vol. 30, Issue 1, pp. 143-156.e5, (2019) (PubMed).

Ouyang, Xu, Lv, Hou, Fan, Xu, Jiang, Wu, Li, Zhang, Guo: "Porcine circovirus type 2 ORF5 protein induces endoplasmic reticulum stress and unfolded protein response in porcine alveolar macrophages." in: Archives of virology, Vol. 164, Issue 5, pp. 1323-1334, (2019) (PubMed).

Zhang, Hu, Ding, Sun, Liu, Han, DeLeo, Sadagopan, Guo, Wang: "Induction of autophagy-dependent apoptosis in cancer cells through activation of ER stress: an uncovered anti-cancer mechanism by anti-alcoholism drug disulfiram." in: American journal of cancer research, Vol. 9, Issue 6, pp. 1266-1281, (2019) (PubMed).

Lee, Kim, Hong, Hwang, Park, Kim, Kim, Yu, Kim, Cheon: "Proteomics-based functional studies reveal that galectin-3 plays a protective role in the pathogenesis of intestinal Behçet's disease." in: Scientific reports, Vol. 9, Issue 1, pp. 11716, (2019) (PubMed).

Gao, Chai, Song, Liu, Chen, Zhou, Ge, Guo, Han, Yang: "Reprogramming the unfolded protein response for replication by porcine reproductive and respiratory syndrome virus." in: PLoS pathogens, Vol. 15, Issue 11, pp. e1008169, (2019) (PubMed).

Hao, Sun, Zhong, Zhang, Sun, Zhou et al.: "Mitochondria-targeted ubiquinone (MitoQ) enhances acetaldehyde clearance by reversing alcohol-induced posttranslational modification of aldehyde dehydrogenase 2: A molecular mechanism of protection ..." in: Redox biology, Vol. 14, pp. 626-636, (2018) (PubMed).

Knowlton, Fernández de Castro, Ashbrook, Gestaut, Zamora, Bauer, Forrest, Frydman, Risco, Dermody: "The TRiC chaperonin controls reovirus replication through outer-capsid folding." in: Nature microbiology, Vol. 3, Issue 4, pp. 481-493, (2018) (PubMed).

So, Chen, Wang, Wu, Huang, Lai, Pan, Kang, Huang: "Midazolam regulated caspase pathway, endoplasmic reticulum stress, autophagy, and cell cycle to induce apoptosis in MA-10 mouse Leydig tumor cells." in: OncoTargets and therapy, Vol. 9, pp. 2519-33, (2016) (PubMed).

Li, Han, Shi: "IRE1?-XBP1 Pathway Is Activated Upon Induction of Single-Prolonged Stress in Rat Neurons of the Medial Prefrontal Cortex." in: Journal of molecular neuroscience : MN, (2015) (PubMed).

Synonyms and alternative names related to XBP1

X-box binding protein 1 (xbp1), X-box binding protein 1 (XBP1), X-box binding protein 1 (Xbp1), X-box binding protein 1 L homeolog (xbp1.L), cb918, D11Ertd39e, HTF, id:ibd1195, TREB-5, treb5, TREB5, trebf, wu:fb02h05, wu:fb63f10, XBP-1, xbp1, xbp1a, xbp1b, XBP1P1, xbp2, XBP2, XBPP1, xXBP1

Protein level used designations for XBP1

  • X-box binding protein 1 pseudogene 1
  • X-box binding protein pseudogene 1
  • X-box binding protein 1
  • X-box-binding protein 1
  • tax-responsive element-binding protein 5
  • tax-responsive element-binding protein 5 homolog
  • XBP-1
  • hepatocarcinogenesis-related transcription factor
  • X-box binding protein 1B
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