XBP1 Products
(X-Box Binding Protein 1 (XBP1))
Categories
This gene encodes a transcription factor that regulates MHC class II genes by binding to a promoter element referred to as an X box. This gene product is a bZIP protein, which was also identified as a cellular transcription factor that binds to an enhancer in the promoter of the T cell leukemia virus type 1 promoter. It may increase expression of viral proteins by acting as the DNA binding partner of a viral transactivator. It has been found that upon accumulation of unfolded proteins in the endoplasmic reticulum (ER), the mRNA of this gene is processed to an active form by an unconventional splicing mechanism that is mediated by the endonuclease inositol-requiring enzyme 1 (IRE1). The resulting loss of 26 nt from the spliced mRNA causes a frame-shift and an isoform XBP1(S), which is the functionally active transcription factor. The isoform encoded by the unspliced mRNA, XBP1(U), is constitutively expressed, and thought to function as a negative feedback regulator of XBP1(S), which shuts off transcription of target genes during the recovery phase of ER stress. A pseudogene of XBP1 has been identified and localized to chromosome 5. [provided by RefSeq, Jul 2008].
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Featured XBP1 Categories
XBP1 Antibodies
High quality antibodies with extensive validation data.
XBP1 ELISA Kits
Reliable ELISA kits for a wide range of species.
XBP1 Proteins
Proteins for various applications incl. WB, ELISA, IF etc.
Recommended XBP1 Antibodies
Product
Reactivity
Application
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Human
Application
WB, IF, IHC (p), ICC
Validations
- (5)
Cat. No.
ABIN2855334
Quantity
100 μL
Datasheet
Datasheet
Reactivity
Human
Application
WB, IHC
Validations
- (5)
Cat. No.
ABIN7271399
Quantity
100 μL
Datasheet
Datasheet
Reactivity
Human
Application
WB, ELISA, IHC, FACS
Validations
- (6)
Cat. No.
ABIN3029642
Quantity
0.4 mL
Datasheet
Datasheet
Recommended XBP1 ELISA Kits
Product
Reactivity
Analytical Method
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Human
Analytical Method
Quantitative Sandwich ELISA
Validations
- (1)
Cat. No.
ABIN6971207
Quantity
96 tests
Datasheet
Datasheet
Reactivity
Human
Analytical Method
Quantitative Sandwich ELISA
Validations
- (1)
Cat. No.
ABIN6960567
Quantity
96 tests
Datasheet
Datasheet
Reactivity
Mouse
Analytical Method
Quantitative Sandwich ELISA
Validations
- (1)
Cat. No.
ABIN6960568
Quantity
96 tests
Datasheet
Datasheet
Recommended XBP1 Proteins
Product
Reactivity
Source
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Human
Source
Wheat germ
Validations
- (1)
Cat. No.
ABIN1325428
Quantity
25 μg
Datasheet
Datasheet
Reactivity
Rat
Source
Escherichia coli (E. coli)
Validations
Cat. No.
ABIN7413280
Quantity
100 μg
Datasheet
Datasheet
Reactivity
Mouse
Source
Escherichia coli (E. coli)
Validations
Cat. No.
ABIN7396589
Quantity
100 μg
Datasheet
Datasheet
Latest Publications for our XBP1 products
: "Hepatic overproduction of 13-HODE due to ALOX15 upregulation contributes to alcohol-induced liver injury in mice." in: Scientific reports, Vol. 7, Issue 1, pp. 8976, (2019) (PubMed).: "Cholesterol Induces CD8+ T Cell Exhaustion in the Tumor Microenvironment." in: Cell metabolism, Vol. 30, Issue 1, pp. 143-156.e5, (2019) (PubMed).
: "Porcine circovirus type 2 ORF5 protein induces endoplasmic reticulum stress and unfolded protein response in porcine alveolar macrophages." in: Archives of virology, Vol. 164, Issue 5, pp. 1323-1334, (2019) (PubMed).
: "Induction of autophagy-dependent apoptosis in cancer cells through activation of ER stress: an uncovered anti-cancer mechanism by anti-alcoholism drug disulfiram." in: American journal of cancer research, Vol. 9, Issue 6, pp. 1266-1281, (2019) (PubMed).
: "Proteomics-based functional studies reveal that galectin-3 plays a protective role in the pathogenesis of intestinal Behçet's disease." in: Scientific reports, Vol. 9, Issue 1, pp. 11716, (2019) (PubMed).
: "Reprogramming the unfolded protein response for replication by porcine reproductive and respiratory syndrome virus." in: PLoS pathogens, Vol. 15, Issue 11, pp. e1008169, (2019) (PubMed).
: "Mitochondria-targeted ubiquinone (MitoQ) enhances acetaldehyde clearance by reversing alcohol-induced posttranslational modification of aldehyde dehydrogenase 2: A molecular mechanism of protection ..." in: Redox biology, Vol. 14, pp. 626-636, (2018) (PubMed).
: "The TRiC chaperonin controls reovirus replication through outer-capsid folding." in: Nature microbiology, Vol. 3, Issue 4, pp. 481-493, (2018) (PubMed).
: "Midazolam regulated caspase pathway, endoplasmic reticulum stress, autophagy, and cell cycle to induce apoptosis in MA-10 mouse Leydig tumor cells." in: OncoTargets and therapy, Vol. 9, pp. 2519-33, (2016) (PubMed).
: "IRE1?-XBP1 Pathway Is Activated Upon Induction of Single-Prolonged Stress in Rat Neurons of the Medial Prefrontal Cortex." in: Journal of molecular neuroscience : MN, (2015) (PubMed).
Synonyms and alternative names related to XBP1
X-box binding protein 1 (xbp1), X-box binding protein 1 (XBP1), X-box binding protein 1 (Xbp1), X-box binding protein 1 L homeolog (xbp1.L), cb918, D11Ertd39e, HTF, id:ibd1195, TREB-5, treb5, TREB5, trebf, wu:fb02h05, wu:fb63f10, XBP-1, xbp1, xbp1a, xbp1b, XBP1P1, xbp2, XBP2, XBPP1, xXBP1Protein level used designations for XBP1
- X-box binding protein 1 pseudogene 1
- X-box binding protein pseudogene 1
- X-box binding protein 1
- X-box-binding protein 1
- tax-responsive element-binding protein 5
- tax-responsive element-binding protein 5 homolog
- XBP-1
- hepatocarcinogenesis-related transcription factor
- X-box binding protein 1B
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