XAF1 Products
(XiAP Associated Factor 1 (XAF1))
Categories
This gene encodes a protein which binds to and counteracts the inhibitory effect of a member of the IAP (inhibitor of apoptosis) protein family. IAP proteins bind to and inhibit caspases which are activated during apoptosis. The proportion of IAPs and proteins which interfere with their activity, such as the encoded protein, affect the progress of the apoptosis signaling pathway. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Feb 2012].
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Featured XAF1 Categories
XAF1 Antibodies
High quality antibodies with extensive validation data.
XAF1 Proteins
Proteins for various applications incl. WB, ELISA, IF etc.
Recommended XAF1 Antibodies
Product
Reactivity
Application
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Mouse, Rat
Application
WB, ELISA, IHC (p), IF (cc), IF (p), IHC (fro)
Validations
- (3)
Cat. No.
ABIN674754
Quantity
100 μL
Datasheet
Datasheet
Reactivity
Human
Application
WB
Validations
- (3)
Cat. No.
ABIN527175
Quantity
100 μg
Datasheet
Datasheet
Reactivity
Human
Application
ELISA, IHC, IF
Validations
- (2)
Cat. No.
ABIN7175921
Quantity
100 μg
Datasheet
Datasheet
Recommended XAF1 ELISA Kits
Product
Reactivity
Analytical Method
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Mouse
Analytical Method
Quantitative Sandwich ELISA
Validations
- (1)
Cat. No.
ABIN6971212
Quantity
96 tests
Datasheet
Datasheet
Recommended XAF1 Proteins
Product
Reactivity
Source
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Human
Source
Escherichia coli (E. coli)
Validations
- (1)
Cat. No.
ABIN7125752
Quantity
50 μg
Datasheet
Datasheet
Reactivity
Human
Source
Wheat germ
Validations
- (1)
Cat. No.
ABIN1325418
Quantity
10 μg
Datasheet
Datasheet
Reactivity
Human
Source
Wheat germ
Validations
- (1)
Cat. No.
ABIN1325416
Quantity
10 μg
Datasheet
Datasheet
Latest Publications for our XAF1 products
: "SARM1 deficiency up-regulates XAF1, promotes neuronal apoptosis, and accelerates prion disease." in: The Journal of experimental medicine, Vol. 216, Issue 4, pp. 743-756, (2019) (PubMed).: "Admixture fine-mapping in African Americans implicates XAF1 as a possible sarcoidosis risk gene." in: PLoS ONE, Vol. 9, Issue 3, pp. e92646, (2014) (PubMed).
: "A co-clinical approach identifies mechanisms and potential therapies for androgen deprivation resistance in prostate cancer." in: Nature genetics, Vol. 45, Issue 7, pp. 747-55, (2013) (PubMed).
: "Combination of DNA methylation inhibitor 5-azacytidine and arsenic trioxide has synergistic activity in myeloma." in: European journal of haematology, Vol. 82, Issue 3, pp. 176-83, (2009) (PubMed).
: "Down-regulation of the pro-apoptotic XIAP associated factor-1 (XAF1) during progression of clear-cell renal cancer." in: BMC cancer, Vol. 9, pp. 276, (2009) (PubMed).
: "Wild-type PABPN1 is anti-apoptotic and reduces toxicity of the oculopharyngeal muscular dystrophy mutation." in: Human molecular genetics, Vol. 17, Issue 8, pp. 1097-108, (2008) (PubMed).
: "XAF1 mediates tumor necrosis factor-alpha-induced apoptosis and X-linked inhibitor of apoptosis cleavage by acting through the mitochondrial pathway." in: The Journal of biological chemistry, Vol. 282, Issue 17, pp. 13059-72, (2007) (PubMed).
: "Xaf1 can cooperate with TNFalpha in the induction of apoptosis, independently of interaction with XIAP." in: Molecular and cellular biochemistry, Vol. 286, Issue 1-2, pp. 67-76, (2006) (PubMed).
: "The Bcl-2 protein family and its role in the development of neoplastic disease." in: Experimental gerontology, Vol. 39, Issue 8, pp. 1125-35, (2004) (PubMed).
: "X-linked inhibitor of apoptosis (XIAP) protein protects against caspase activation and tissue loss after neonatal hypoxia-ischemia." in: Neurobiology of disease, Vol. 16, Issue 1, pp. 179-89, (2004) (PubMed).
Synonyms and alternative names related to XAF1
XIAP associated factor 1 (xaf1), XIAP associated factor 1 (XAF1), XIAP associated factor 1 (Xaf1), BIRC4BP, Fbxo39, HSXIAPAF1, XIAPAF1Protein level used designations for XAF1
- XIAP-associated factor 1
- BIRC4 binding protein
- BIRC4-binding protein
- F-box protein 39
- novel TRAF-type zinc finger protein
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