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XAF1 Products

(XiAP Associated Factor 1 (XAF1))

Categories

This gene encodes a protein which binds to and counteracts the inhibitory effect of a member of the IAP (inhibitor of apoptosis) protein family. IAP proteins bind to and inhibit caspases which are activated during apoptosis. The proportion of IAPs and proteins which interfere with their activity, such as the encoded protein, affect the progress of the apoptosis signaling pathway. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Feb 2012].

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Featured XAF1 Categories

XAF1 Antibodies

High quality antibodies with extensive validation data.

XAF1 Proteins

Proteins for various applications incl. WB, ELISA, IF etc.

Recommended XAF1 Antibodies

Product
Reactivity
Application
Validations
Cat. No.
Quantity
Datasheet
Reactivity Mouse, Rat
Application WB, ELISA, IHC (p), IF (cc), IF (p), IHC (fro)
Validations
  • (3)
Cat. No. ABIN674754
Quantity 100 μL
Datasheet Datasheet
Reactivity Human
Application WB
Validations
  • (3)
Cat. No. ABIN527175
Quantity 100 μg
Datasheet Datasheet
Reactivity Human
Application ELISA, IHC, IF
Validations
  • (2)
Cat. No. ABIN7175921
Quantity 100 μg
Datasheet Datasheet

Recommended XAF1 ELISA Kits

Product
Reactivity
Analytical Method
Validations
Cat. No.
Quantity
Datasheet
Reactivity Mouse
Analytical Method Quantitative Sandwich ELISA
Validations
  • (1)
Cat. No. ABIN6971212
Quantity 96 tests
Datasheet Datasheet

Recommended XAF1 Proteins

Product
Reactivity
Source
Validations
Cat. No.
Quantity
Datasheet
Reactivity Human
Source Escherichia coli (E. coli)
Validations
  • (1)
Cat. No. ABIN7125752
Quantity 50 μg
Datasheet Datasheet
Reactivity Human
Source Wheat germ
Validations
  • (1)
Cat. No. ABIN1325418
Quantity 10 μg
Datasheet Datasheet
Reactivity Human
Source Wheat germ
Validations
  • (1)
Cat. No. ABIN1325416
Quantity 10 μg
Datasheet Datasheet

Latest Publications for our XAF1 products

Zhu, Li, Frontzek, Liu, Aguzzi: "SARM1 deficiency up-regulates XAF1, promotes neuronal apoptosis, and accelerates prion disease." in: The Journal of experimental medicine, Vol. 216, Issue 4, pp. 743-756, (2019) (PubMed).

Levin, Iannuzzi, Montgomery, Trudeau, Datta, Adrianto, Chitale, McKeigue, Rybicki: "Admixture fine-mapping in African Americans implicates XAF1 as a possible sarcoidosis risk gene." in: PLoS ONE, Vol. 9, Issue 3, pp. e92646, (2014) (PubMed).

Lunardi, Ala, Epping, Salmena, Clohessy, Webster, Wang, Mazzucchelli, Bianconi, Stack, Lis, Patnaik, Cantley, Bubley, Cordon-Cardo, Gerald, Montironi, Signoretti, Loda, Nardella, Pandolfi: "A co-clinical approach identifies mechanisms and potential therapies for androgen deprivation resistance in prostate cancer." in: Nature genetics, Vol. 45, Issue 7, pp. 747-55, (2013) (PubMed).

Chen, Wang, Huang, Lin, Wu, Sun, Chang, Feng: "Combination of DNA methylation inhibitor 5-azacytidine and arsenic trioxide has synergistic activity in myeloma." in: European journal of haematology, Vol. 82, Issue 3, pp. 176-83, (2009) (PubMed).

Kempkensteffen, Fritzsche, Johannsen, Weikert, Hinz, Dietel, Riener, Moch, Jung, Krause, Miller, Kristiansen: "Down-regulation of the pro-apoptotic XIAP associated factor-1 (XAF1) during progression of clear-cell renal cancer." in: BMC cancer, Vol. 9, pp. 276, (2009) (PubMed).

Davies, Sarkar, Rubinsztein: "Wild-type PABPN1 is anti-apoptotic and reduces toxicity of the oculopharyngeal muscular dystrophy mutation." in: Human molecular genetics, Vol. 17, Issue 8, pp. 1097-108, (2008) (PubMed).

Straszewski-Chavez, Visintin, Karassina, Los, Liston, Halaban, Fadiel, Mor: "XAF1 mediates tumor necrosis factor-alpha-induced apoptosis and X-linked inhibitor of apoptosis cleavage by acting through the mitochondrial pathway." in: The Journal of biological chemistry, Vol. 282, Issue 17, pp. 13059-72, (2007) (PubMed).

Xia, Novak, Lewis, Duckett, Phillips: "Xaf1 can cooperate with TNFalpha in the induction of apoptosis, independently of interaction with XIAP." in: Molecular and cellular biochemistry, Vol. 286, Issue 1-2, pp. 67-76, (2006) (PubMed).

Heiser, Labi, Erlacher, Villunger: "The Bcl-2 protein family and its role in the development of neoplastic disease." in: Experimental gerontology, Vol. 39, Issue 8, pp. 1125-35, (2004) (PubMed).

Wang, Zhu, Wang, Hagberg, Korhonen, Sandberg, Lindholm, Blomgren: "X-linked inhibitor of apoptosis (XIAP) protein protects against caspase activation and tissue loss after neonatal hypoxia-ischemia." in: Neurobiology of disease, Vol. 16, Issue 1, pp. 179-89, (2004) (PubMed).

Synonyms and alternative names related to XAF1

XIAP associated factor 1 (xaf1), XIAP associated factor 1 (XAF1), XIAP associated factor 1 (Xaf1), BIRC4BP, Fbxo39, HSXIAPAF1, XIAPAF1

Protein level used designations for XAF1

  • XIAP-associated factor 1
  • BIRC4 binding protein
  • BIRC4-binding protein
  • F-box protein 39
  • novel TRAF-type zinc finger protein
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