WWOX Products
(WW Domain Containing Oxidoreductase (WWOX))
Categories
WW domain-containing proteins are found in all eukaryotes and play an important role in the regulation of a wide variety of cellular functions such as protein degradation, transcription, and RNA splicing. This gene encodes a protein which contains 2 WW domains and a short-chain dehydrogenase/reductase domain (SRD). The highest normal expression of this gene is detected in hormonally regulated tissues such as testis, ovary, and prostate. This expression pattern and the presence of an SRD domain suggest a role for this gene in steroid metabolism. The encoded protein is more than 90% identical to the mouse protein, which is an essential mediator of tumor necrosis factor-alpha-induced apoptosis, suggesting a similar, important role in apoptosis for the human protein. In addition, there is evidence that this gene behaves as a suppressor of tumor growth. Alternative splicing of this gene generates transcript variants that encode different isoforms. [provided by RefSeq, Jul 2008].
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Featured WWOX Categories
WWOX Antibodies
High quality antibodies with extensive validation data.
WWOX ELISA Kits
Reliable ELISA kits for a wide range of species.
WWOX Proteins
Proteins for various applications incl. WB, ELISA, IF etc.
Recommended WWOX Antibodies
Product
Reactivity
Application
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Human
Application
WB, ELISA, IHC, IF, IP
Validations
- (6)
Cat. No.
ABIN7175871
Quantity
100 μg
Datasheet
Datasheet
Reactivity
Human, Mouse
Application
WB, ELISA, IHC (p), FACS, IF (cc), IF (p), IHC (fro)
Validations
- (1)
- (3)
Cat. No.
ABIN670551
Quantity
100 μL
Datasheet
Datasheet
Reactivity
Human, Mouse, Rat
Application
WB, ELISA, IHC
Validations
- (5)
Cat. No.
ABIN5693294
Quantity
100 μg
Datasheet
Datasheet
Recommended WWOX ELISA Kits
Product
Reactivity
Analytical Method
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Human, Mouse
Analytical Method
Qualitative Cell ELISA
Validations
Cat. No.
ABIN1380821
Quantity
2 x 96 tests
Datasheet
Datasheet
Reactivity
Chicken
Analytical Method
Validations
Cat. No.
ABIN1167525
Quantity
96 tests
Datasheet
Datasheet
Recommended WWOX Proteins
Product
Reactivity
Source
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Human
Source
Wheat germ
Validations
- (1)
Cat. No.
ABIN1325403
Quantity
10 μg
Datasheet
Datasheet
Reactivity
Human
Source
Escherichia coli (E. coli)
Validations
- (1)
Cat. No.
ABIN7278826
Quantity
100 μg
Datasheet
Datasheet
Reactivity
Human
Source
Escherichia coli (E. coli)
Validations
Cat. No.
ABIN2132583
Quantity
50 μg
Datasheet
Datasheet
Latest Publications for our WWOX products
: "PGBD5 promotes site-specific oncogenic mutations in human tumors. ..." in: Nature genetics, Vol. 49, Issue 7, pp. 1005-1014, (2017) (PubMed).: "The ectopic expression of BRCA1 is associated with genesis, progression, and prognosis of breast cancer in young patients." in: Diagnostic pathology, Vol. 7, pp. 181, (2013) (PubMed).
: "WWOX gene restoration prevents lung cancer growth in vitro and in vivo." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 102, Issue 43, pp. 15611-6, (2005) (PubMed).
: "Frequent downregulation and loss of WWOX gene expression in human hepatocellular carcinoma." in: British journal of cancer, Vol. 91, Issue 4, pp. 753-9, (2004) (PubMed).
: "JNK1 physically interacts with WW domain-containing oxidoreductase (WOX1) and inhibits WOX1-mediated apoptosis." in: The Journal of biological chemistry, Vol. 278, Issue 11, pp. 9195-202, (2003) (PubMed).
: "WWOX, the FRA16D gene, behaves as a suppressor of tumor growth." in: Cancer research, Vol. 61, Issue 22, pp. 8068-73, (2001) (PubMed).
: "WWOX: a candidate tumor suppressor gene involved in multiple tumor types." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 98, Issue 20, pp. 11417-22, (2001) (PubMed).
: "WWOX, a novel WW domain-containing protein mapping to human chromosome 16q23.3-24.1, a region frequently affected in breast cancer." in: Cancer research, Vol. 60, Issue 8, pp. 2140-5, (2000) (PubMed).
: "Common chromosomal fragile site FRA16D sequence: identification of the FOR gene spanning FRA16D and homozygous deletions and translocation breakpoints in cancer cells." in: Human molecular genetics, Vol. 9, Issue 11, pp. 1651-63, (2000) (PubMed).
Synonyms and alternative names related to WWOX
WW domain containing oxidoreductase (Wwox), WW domain-containing oxidoreductase (LOC411815), WW domain containing oxidoreductase (WWOX), WW domain-containing oxidoreductase (CpipJ_CPIJ004939), WW domain-containing oxidoreductase (MCYG_01584), WW domain-containing oxidoreductase (VDBG_05631), WW domain-containing oxidoreductase (VDBG_01326), WW domain-containing oxidoreductase (VDBG_06753), WW domain-containing oxidoreductase (Tsp_03967), WW domain-containing oxidoreductase (LOC100284583), WW domain containing oxidoreductase (wwox), WW domain-containing oxidoreductase (Wwox), 5330426P09Rik, 9030416C10Rik, anon-EST:Posey177, CG7221, D16S432E, Dmel\\CG7221, DmWWOX, FOR, FRA16D, GB11795, HHCMA56, PRO0128, SDR41C1, WOX1, WWOX, zgc:55975Protein level used designations for WWOX
- CG7221-PA
- Wwox-PA
- WW domain-containing oxidoreductase
- retinol dehydrogenase 12
- WW domain containing oxidoreductase
- WW domain-containing protein WWOX
- fragile site FRA16D oxidoreductase
- short chain dehydrogenase/reductase family 41C, member 1
- WW-domain oxidoreductase
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