WT1 Products
(Wilms Tumor 1 (WT1))
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This gene encodes a transcription factor that contains four zinc-finger motifs at the C-terminus and a proline/glutamine-rich DNA-binding domain at the N-terminus. It has an essential role in the normal development of the urogenital system, and it is mutated in a small subset of patients with Wilm's tumors. This gene exhibits complex tissue-specific and polymorphic imprinting pattern, with biallelic, and monoallelic expression from the maternal and paternal alleles in different tissues. Multiple transcript variants have been described. In several variants, there is evidence for the use of a non-AUG (CUG) translation initiation site upstream of and in-frame with the first AUG. Authors of PMID:7926762 also provide evidence that WT1 mRNA undergoes RNA editing in human and rat, and that this process is tissue-restricted and developmentally regulated. [provided by RefSeq, Oct 2010].
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Featured WT1 Categories
WT1 Antibodies
High quality antibodies with extensive validation data.
WT1 ELISA Kits
Reliable ELISA kits for a wide range of species.
WT1 Proteins
Proteins for various applications incl. WB, ELISA, IF etc.
Recommended WT1 Antibodies
Product
Reactivity
Application
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Human
Application
FACS, IHC, WB, ELISA, ICC
Validations
- (8)
Cat. No.
ABIN7193614
Quantity
100 μL
Datasheet
Datasheet
Reactivity
Human
Application
WB
Validations
- (1)
- (5)
Cat. No.
ABIN3021698
Quantity
100 μL
Datasheet
Datasheet
Reactivity
Human, Mouse
Application
IF, FACS, WB, IHC (p)
Validations
- (5)
Cat. No.
ABIN655904
Quantity
400 μL
Datasheet
Datasheet
Recommended WT1 ELISA Kits
Product
Reactivity
Analytical Method
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Human
Analytical Method
Quantitative Sandwich ELISA
Validations
- (1)
Cat. No.
ABIN6971178
Quantity
96 tests
Datasheet
Datasheet
Reactivity
Human
Analytical Method
Quantitative Sandwich ELISA
Validations
- (1)
Cat. No.
ABIN6960529
Quantity
96 tests
Datasheet
Datasheet
Reactivity
Mouse
Analytical Method
Quantitative Competition ELISA
Validations
Cat. No.
ABIN5592787
Quantity
96 tests
Datasheet
Datasheet
Recommended WT1 Proteins
Product
Reactivity
Source
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Human
Source
Escherichia coli (E. coli)
Validations
- (1)
Cat. No.
ABIN7125729
Quantity
50 μg
Datasheet
Datasheet
Reactivity
Human
Source
Wheat germ
Validations
- (1)
Cat. No.
ABIN1325392
Quantity
10 μg
Datasheet
Datasheet
Reactivity
Human
Source
Wheat germ
Validations
- (1)
Cat. No.
ABIN1325391
Quantity
25 μg
Datasheet
Datasheet
Latest Publications for our WT1 products
: "Loss of phosphatidylserine flippase β-subunit Tmem30a in podocytes leads to albuminuria and glomerulosclerosis." in: Disease models & mechanisms, Vol. 14, Issue 6, (2022) (PubMed).: "Nuclear paraspeckle assembly transcript 1 promotes the podocyte injury via targeting miR-23b-3p/B-cell lymphoma-2 interacting protein 3 like axis." in: Renal failure, Vol. 44, Issue 1, pp. 1961-1975, (2022) (PubMed).
: "Differentiation of human iPSCs into functional podocytes." in: PLoS ONE, Vol. 13, Issue 9, pp. e0203869, (2019) (PubMed).
: "Focal and segmental glomerulosclerosis in murine models: a histological and ultrastructural characterization with immunohistochemistry correlation of glomerular CD44 and WT1 expression." in: Ultrastructural pathology, Vol. 42, Issue 5, pp. 430-439, (2018) (PubMed).
: "Podocyte-Specific Loss of Krüppel-Like Factor 6 Increases Mitochondrial Injury in Diabetic Kidney Disease." in: Diabetes, Vol. 67, Issue 11, pp. 2420-2433, (2018) (PubMed).
: "A preclinical mouse model of glioma with an alternative mechanism of telomere maintenance (ALT)." in: International journal of cancer, Vol. 136, Issue 7, pp. 1546-58, (2015) (PubMed).
: "Hypoxia-sensitive epigenetic regulation of an antisense-oriented lncRNA controls WT1 expression in myeloid leukemia cells." in: PLoS ONE, Vol. 10, Issue 3, pp. e0119837, (2015) (PubMed).
: "Renal progenitors derived from human iPSCs engraft and restore function in a mouse model of acute kidney injury." in: Scientific reports, Vol. 5, pp. 8826, (2015) (PubMed).
: "BAMBI elimination enhances alternative TGF-β signaling and glomerular dysfunction in diabetic mice." in: Diabetes, Vol. 64, Issue 6, pp. 2220-33, (2015) (PubMed).
: "Rapamycin promotes podocyte autophagy and ameliorates renal injury in diabetic mice." in: Molecular and cellular biochemistry, Vol. 394, Issue 1-2, pp. 145-54, (2014) (PubMed).
Synonyms and alternative names related to WT1
Wilms tumor 1 (WT1), Wilms tumor 1 S homeolog (wt1.S), Wilms tumor 1 (wt1), wilms tumor 1b (wt1b), Wilms tumor 1 (Wt1), Wilms tumor protein (wt1), Wilms tumor 1 homolog (Wt1), Wilms tumor 1 L homeolog (wt1.L), AWT1, CWT1, D630046I19Rik, EWS-WT1, GUD, gud, NPHS4, si:ch211-160j6.3, WAGR, wagr, WIT-2, wit-2, wt-1, WT-1, Wt-1, WT1, wt1, WT33, wt33, XeWT1, xWT1, xwt1, XWT1a, XWT1b, zgc:152697Protein level used designations for WT1
- Wilms tumor protein
- amino-terminal domain of EWS
- last three zinc fingers of the DNA-binding domain of WT1
- Chick Wilm's tumour protein
- Wilms tumor 1
- Wilms tumor protein homolog A
- Wilms tumor protein homolog
- Wilms tumor suppressor protein 1b
- Wilm's tumor suppressor
- Wilms tumor protein homolog B
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