WRAP53 Products
(WD Repeat Containing, Antisense To TP53 (WRAP53))
Categories
This gene encodes an essential component of the telomerase holoenzyme complex, a ribonucleoprotein complex required for telomere synthesis. This protein is enriched in Cajal bodies, nuclear sites of RNP processing that are important for telomerase function. It interacts with dyskerin, TERT and TERC, other components of active telomerase, and with small Cajal body RNAs (scaRNAs), which are involved in modifying splicing RNAs. This mRNA also functions as a p53 antisense transcript, that regulates endogenous p53 mRNA levels and further induction of p53 protein by targeting the 5' untranslated region of p53 mRNA. Alternatively spliced transcript variants which differ only in the 5' UTR have been found for this gene. [provided by RefSeq, Mar 2011].
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Featured WRAP53 Categories
WRAP53 Antibodies
High quality antibodies with extensive validation data.
WRAP53 ELISA Kits
Reliable ELISA kits for a wide range of species.
WRAP53 Proteins
Proteins for various applications incl. WB, ELISA, IF etc.
Recommended WRAP53 Antibodies
Product
Reactivity
Application
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Human
Application
WB, ELISA, IF
Validations
- (1)
- (4)
Cat. No.
ABIN527367
Quantity
100 μg
Datasheet
Datasheet
Reactivity
Human
Application
WB, IF
Validations
- (1)
- (3)
Cat. No.
ABIN527366
Quantity
100 μg
Datasheet
Datasheet
Reactivity
Human
Application
WB
Validations
- (1)
- (1)
Cat. No.
ABIN527365
Quantity
50 μg
Datasheet
Datasheet
Recommended WRAP53 ELISA Kits
Product
Reactivity
Analytical Method
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Human
Analytical Method
Validations
Cat. No.
ABIN1161126
Quantity
96 tests
Datasheet
Datasheet
Reactivity
Mouse
Analytical Method
Validations
Cat. No.
ABIN1161127
Quantity
96 tests
Datasheet
Datasheet
Reactivity
Rat
Analytical Method
Validations
Cat. No.
ABIN1161128
Quantity
96 tests
Datasheet
Datasheet
Recommended WRAP53 Proteins
Product
Reactivity
Source
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Human
Source
Wheat germ
Validations
- (1)
Cat. No.
ABIN1325280
Quantity
10 μg
Datasheet
Datasheet
Reactivity
Human
Source
Wheat germ
Validations
- (1)
Cat. No.
ABIN1325282
Quantity
10 μg
Datasheet
Datasheet
Reactivity
Human
Source
Tobacco (Nicotiana tabacum)
Validations
Cat. No.
ABIN3096370
Quantity
1 mg
Datasheet
Datasheet
Latest Publications for our WRAP53 products
: "N-terminal residues of human dyskerin are required for interactions with telomerase RNA that prevent RNA degradation." in: Nucleic acids research, Vol. 47, Issue 10, pp. 5368-5380, (2019) (PubMed).: "Clinical, cellular, and bioinformatic analyses reveal involvement of WRAP53 overexpression in carcinogenesis of lung adenocarcinoma." in: Tumour biology, Vol. 39, Issue 3, pp. 1010428317694309, (2017) (PubMed).
: "Minimized human telomerase maintains telomeres and resolves endogenous roles of H/ACA proteins, TCAB1, and Cajal bodies." in: eLife, Vol. 5, (2016) (PubMed).
: "Dynamics of Human Telomerase Holoenzyme Assembly and Subunit Exchange across the Cell Cycle." in: The Journal of biological chemistry, Vol. 290, Issue 35, pp. 21320-35, (2015) (PubMed).
: "Human regulator of telomere elongation helicase 1 (RTEL1) is required for the nuclear and cytoplasmic trafficking of pre-U2 RNA." in: Nucleic acids research, Vol. 43, Issue 3, pp. 1834-47, (2015) (PubMed).
: "Downregulation of the cancer susceptibility protein WRAP53β in epithelial ovarian cancer leads to defective DNA repair and poor clinical outcome." in: Cell death & disease, Vol. 6, pp. e1892, (2015) (PubMed).
: "The scaffold protein WRAP53? orchestrates the ubiquitin response critical for DNA double-strand break repair." in: Genes & development, Vol. 28, Issue 24, pp. 2726-38, (2014) (PubMed).
: "TCAB1: a potential target for diagnosis and therapy of head and neck carcinomas." in: Molecular cancer, Vol. 13, pp. 180, (2014) (PubMed).
: "Telomerase recruitment requires both TCAB1 and Cajal bodies independently." in: Molecular and cellular biology, Vol. 32, Issue 13, pp. 2384-95, (2012) (PubMed).
: "WRAP53 promotes cancer cell survival and is a potential target for cancer therapy." in: Cell death & disease, Vol. 2, pp. e114, (2011) (PubMed).
Synonyms and alternative names related to WRAP53
WD repeat containing antisense to TP53 (WRAP53), WD repeat containing, antisense to TP53 (Wrap53), WD repeat containing, antisense to Trp53 (Wrap53), BC021790, DKCB3, TCAB1, WDR79, Wdr79Protein level used designations for WRAP53
- WD repeat-containing protein 79
- WD40 protein Wrap53
- WD40 repeat-containing protein encoding RNA antisense to p53
- telomerase Cajal body protein 1
- WD repeat domain 79
- WD40 repeat-containing protein encoded by RNA antisense to p53
- WD repeat containing, antisense to TP53
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