WNK4 Products
(WNK Lysine Deficient Protein Kinase 4 (WNK4))
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This gene encodes a member of the WNK family of serine-threonine protein kinases. The kinase is part of the tight junction complex in kidney cells, and regulates the balance between NaCl reabsorption and K(+) secretion. The kinase regulates the activities of several types of ion channels, cotransporters, and exchangers involved in electrolyte flux in epithelial cells. Mutations in this gene result in pseudohypoaldosteronism type IIB.[provided by RefSeq, Sep 2009].
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Featured WNK4 Categories
WNK4 Antibodies
High quality antibodies with extensive validation data.
WNK4 Proteins
Proteins for various applications incl. WB, ELISA, IF etc.
Recommended WNK4 Antibodies
Product
Reactivity
Application
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Human
Application
ELISA, IHC, IF
Validations
- (3)
Cat. No.
ABIN7169234
Quantity
100 μg
Datasheet
Datasheet
Reactivity
Human
Application
ELISA, WB
Validations
- (2)
Cat. No.
ABIN528800
Quantity
100 μg
Datasheet
Datasheet
Reactivity
Mouse
Application
ELISA, WB
Validations
- (1)
Cat. No.
ABIN668526
Quantity
100 μL
Datasheet
Datasheet
Recommended WNK4 Proteins
Product
Reactivity
Source
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Human
Source
Wheat germ
Validations
- (1)
Cat. No.
ABIN1325354
Quantity
10 μg
Datasheet
Datasheet
Reactivity
Mouse
Source
Insect Cells
Validations
Cat. No.
ABIN5509230
Quantity
10 μg
Datasheet
Datasheet
Reactivity
Human
Source
Tobacco (Nicotiana tabacum)
Validations
Cat. No.
ABIN3096394
Quantity
1 mg
Datasheet
Datasheet
Latest Publications for our WNK4 products
: "High frequency and wide range of human kidney papillary crystalline plugs." in: Urolithiasis, (2018) (PubMed).: "Role of nitric oxide and WNK-SPAK/OSR1-KCC2 signaling in daily changes in GABAergic inhibition in the rat dorsal raphe neurons." in: Neuropharmacology, Vol. 135, pp. 355-367, (2018) (PubMed).
: "WNK-Cab39-NKCC1 signaling increases the susceptibility to ischemic brain damage in hypertensive rats." in: Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism, Vol. 37, Issue 8, pp. 2780-2794, (2017) (PubMed).
: "Gender difference in kidney electrolyte transport. I. Role of AT1a receptor in thiazide-sensitive Na+-Cl- cotransporter activity and expression in male and female mice." in: American journal of physiology. Renal physiology, Vol. 313, Issue 2, pp. F505-F513, (2017) (PubMed).
: "FGF23 promotes renal calcium reabsorption through the TRPV5 channel." in: The EMBO journal, Vol. 33, Issue 3, pp. 229-46, (2014) (PubMed).
: "Immunolocalization of WNK4 in mouse kidney." in: Histochemistry and cell biology, Vol. 136, Issue 1, pp. 25-35, (2011) (PubMed).
: "Pathophysiological roles of WNK kinases in the kidney." in: Pflügers Archiv : European journal of physiology, Vol. 460, Issue 4, pp. 695-702, (2010) (PubMed).
: "WNK4 diverts the thiazide-sensitive NaCl cotransporter to the lysosome and stimulates AP-3 interaction." in: The Journal of biological chemistry, Vol. 284, Issue 27, pp. 18471-80, (2009) (PubMed).
: "Regulation of blood pressure, the epithelial sodium channel (ENaC), and other key renal sodium transporters by chronic insulin infusion in rats." in: American journal of physiology. Renal physiology, Vol. 290, Issue 5, pp. F1055-64, (2006) (PubMed).
: "WNK4 regulates apical and basolateral Cl- flux in extrarenal epithelia." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 101, Issue 7, pp. 2064-9, (2004) (PubMed).
Synonyms and alternative names related to WNK4
WNK lysine deficient protein kinase 4 (WNK4), WNK lysine deficient protein kinase 4 (Wnk4), 2010002J11Rik, Ac2-059, PHA2B, Pha2b, PRKWNK4, Prkwnk4, WNK4Protein level used designations for WNK4
- WNK lysine deficient protein kinase 4
- protein kinase lysine-deficient 4
- protein kinase with no lysine 4
- serine/threonine-protein kinase WNK4
- protein kinase, lysine deficient 4
- WNK4 Ser/Thr kinase
- protein kinase, lysine-deficient 4
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