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WIPI2 Products

(WD Repeat Domain, Phosphoinositide Interacting 2 (WIPI2))

Categories

WD40 repeat proteins are key components of many essential biologic functions. They regulate the assembly of multiprotein complexes by presenting a beta-propeller platform for simultaneous and reversible protein-protein interactions. Members of the WIPI subfamily of WD40 repeat proteins, such as WIPI2, have a 7-bladed propeller structure and contain a conserved motif for interaction with phospholipids (Proikas-Cezanne et al., 2004 [PubMed 15602573]).[supplied by OMIM, Mar 2008].

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Featured WIPI2 Categories

WIPI2 Antibodies

High quality antibodies with extensive validation data.

WIPI2 Proteins

Proteins for various applications incl. WB, ELISA, IF etc.

Recommended WIPI2 Antibodies

Product
Reactivity
Application
Validations
Cat. No.
Quantity
Datasheet
Reactivity Human, Mouse
Application WB, IHC
Validations
  • (3)
Cat. No. ABIN7011849
Quantity 60 μL
Datasheet Datasheet
Reactivity Human
Application WB, IHC (p)
Validations
  • (2)
  • (2)
Cat. No. ABIN657237
Quantity 400 μL
Datasheet Datasheet
Reactivity Human
Application WB, IHC, IF, ICC
Validations
  • (3)
Cat. No. ABIN5066239
Quantity 100 μg
Datasheet Datasheet

Recommended WIPI2 ELISA Kits

Product
Reactivity
Analytical Method
Validations
Cat. No.
Quantity
Datasheet
Reactivity Human
Analytical Method Quantitative Sandwich ELISA
Validations
Cat. No. ABIN6234721
Quantity 96 tests
Datasheet Datasheet

Recommended WIPI2 Proteins

Product
Reactivity
Source
Validations
Cat. No.
Quantity
Datasheet
Reactivity Human
Source Wheat germ
Validations
  • (1)
Cat. No. ABIN1325339
Quantity 10 μg
Datasheet Datasheet
Reactivity Human
Source Tobacco (Nicotiana tabacum)
Validations
Cat. No. ABIN3096371
Quantity 1 mg
Datasheet Datasheet
Reactivity Xenopus laevis
Source Yeast
Validations
Cat. No. ABIN1678289
Quantity 1 mg
Datasheet Datasheet

Latest Publications for our WIPI2 products

Burbulla, Fitzgerald, Stegen, Westermeier, Thost, Kato, Mokranjac, Sauerwald, Martins, Woitalla, Rapaport, Riess, Proikas-Cezanne, Rasse, Krüger: "Mitochondrial proteolytic stress induced by loss of mortalin function is rescued by Parkin and PINK1." in: Cell death & disease, Vol. 5, pp. e1180, (2014) (PubMed).

Dooley, Razi, Polson, Girardin, Wilson, Tooze: "WIPI2 links LC3 conjugation with PI3P, autophagosome formation, and pathogen clearance by recruiting Atg12-5-16L1." in: Molecular cell, Vol. 55, Issue 2, pp. 238-52, (2014) (PubMed).

Karanasios, Stapleton, Manifava, Ktistakis: "Imaging autophagy." in: Current protocols in cytometry / editorial board, J. Paul Robinson, managing editor ... [et al.], Vol. 69, pp. 12.34.1-12.34.16, (2014) (PubMed).

Polson, de Lartigue, Rigden, Reedijk, Urbé, Clague, Tooze: "Mammalian Atg18 (WIPI2) localizes to omegasome-anchored phagophores and positively regulates LC3 lipidation." in: Autophagy, Vol. 6, Issue 4, pp. 506-22, (2013) (PubMed).

Nemazanyy, Blaauw, Paolini, Caillaud, Protasi, Mueller, Proikas-Cezanne, Russell, Guan, Nishino, Sandri, Pende, Panasyuk: "Defects of Vps15 in skeletal muscles lead to autophagic vacuolar myopathy and lysosomal disease." in: EMBO molecular medicine, Vol. 5, Issue 6, pp. 870-90, (2013) (PubMed).

Stadler, Rexhepaj, Singan, Murphy, Pepperkok, Uhlén, Simpson, Lundberg: "Immunofluorescence and fluorescent-protein tagging show high correlation for protein localization in mammalian cells." in: Nature methods, Vol. 10, Issue 4, pp. 315-23, (2013) (PubMed).

Synonyms and alternative names related to WIPI2

WD repeat domain, phosphoinositide interacting 2 L homeolog (wipi2.L), WD repeat domain, phosphoinositide interacting 2 (WIPI2), WD repeat domain, phosphoinositide interacting 2 (Wipi2), 1110018O08Rik, 2510001I10Rik, ATG18B, Atg21, WIPI-2

Protein level used designations for WIPI2

  • WIPI-2
  • WD repeat domain phosphoinositide-interacting protein 2
  • WD40 repeat protein interacting with phosphoinositides 2
  • WIPI49-like protein 2
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