WHSC1 Products
(Wolf-Hirschhorn Syndrome Candidate 1 (WHSC1))
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This gene encodes a protein that contains four domains present in other developmental proteins: a PWWP domain, an HMG box, a SET domain, and a PHD-type zinc finger. It is expressed ubiquitously in early development. Wolf-Hirschhorn syndrome (WHS) is a malformation syndrome associated with a hemizygous deletion of the distal short arm of chromosome 4. This gene maps to the 165 kb WHS critical region and has also been involved in the chromosomal translocation t(4\;14)(p16.3\;q32.3) in multiple myelomas. Alternative splicing of this gene results in multiple transcript variants encoding different isoforms. Some transcript variants are nonsense-mediated mRNA (NMD) decay candidates, hence not represented as reference sequences. [provided by RefSeq, Jul 2008].
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Featured WHSC1 Categories
WHSC1 Antibodies
High quality antibodies with extensive validation data.
WHSC1 Proteins
Proteins for various applications incl. WB, ELISA, IF etc.
Recommended WHSC1 Antibodies
Product
Reactivity
Application
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Human
Application
WB, IF
Validations
- (1)
- (3)
Cat. No.
ABIN521379
Quantity
50 μg
Datasheet
Datasheet
Reactivity
Human
Application
WB, IHC
Validations
- (3)
Cat. No.
ABIN6150213
Quantity
100 μL
Datasheet
Datasheet
Reactivity
Human
Application
IHC, ELISA, IF
Validations
- (2)
Cat. No.
ABIN7155501
Quantity
100 μg
Datasheet
Datasheet
Recommended WHSC1 Proteins
Product
Reactivity
Source
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Human
Source
Escherichia coli (E. coli)
Validations
- (1)
Cat. No.
ABIN7125739
Quantity
50 μg
Datasheet
Datasheet
Reactivity
Human
Source
Wheat germ
Validations
- (1)
Cat. No.
ABIN1325322
Quantity
10 μg
Datasheet
Datasheet
Reactivity
Human
Source
Baculovirus
Validations
- (2)
Cat. No.
ABIN2669701
Quantity
20 μg
Datasheet
Datasheet
Latest Publications for our WHSC1 products
: "The Novel Bromodomain and Extraterminal Domain Inhibitor INCB054329 Induces Vulnerabilities in Myeloma Cells That Inform Rational Combination Strategies. ..." in: Clinical cancer research : an official journal of the American Association for Cancer Research, Vol. 25, Issue 1, pp. 300-311, (2019) (PubMed).: "MMSET is dynamically regulated during cell-cycle progression and promotes normal DNA replication." in: Cell cycle (Georgetown, Tex.), Vol. 15, Issue 1, pp. 95-105, (2016) (PubMed).
: "NSD2 contributes to oncogenic RAS-driven transcription in lung cancer cells through long-range epigenetic activation." in: Scientific reports, Vol. 6, pp. 32952, (2016) (PubMed).
: "NSD2 is recruited through its PHD domain to oncogenic gene loci to drive multiple myeloma." in: Cancer research, Vol. 73, Issue 20, pp. 6277-88, (2013) (PubMed).
: "The histone methyltransferase MMSET regulates class switch recombination." in: Journal of immunology (Baltimore, Md. : 1950), Vol. 190, Issue 2, pp. 756-63, (2013) (PubMed).
: "Histone lysine methyltransferase Wolf-Hirschhorn syndrome candidate 1 is involved in human carcinogenesis through regulation of the Wnt pathway." in: Neoplasia (New York, N.Y.), Vol. 13, Issue 10, pp. 887-98, (2011) (PubMed).
: "The protein expression of TRP-1 and galectin-1 in cutaneous malignant melanomas." in: Cancer genomics & proteomics, Vol. 5, Issue 6, pp. 293-300, (2009) (PubMed).
: "Identification of a novel proliferation-related protein, WHSC1 4a, in human gliomas." in: Neuro-oncology, Vol. 10, Issue 1, pp. 45-51, (2008) (PubMed).
: "The MMSET protein is a histone methyltransferase with characteristics of a transcriptional corepressor." in: Blood, Vol. 111, Issue 6, pp. 3145-54, (2008) (PubMed).
Synonyms and alternative names related to WHSC1
nuclear receptor binding SET domain protein 2 (NSD2), nuclear receptor binding SET domain protein 2 (nsd2), Wolf-Hirschhorn syndrome candidate 1 (WHSC1), nuclear receptor binding SET domain protein 2 (Nsd2), 5830445G22Rik, 9430010A17Rik, AW555663, C130020C13Rik, D030027O06Rik, D930023B08Rik, fc12c04, mKIAA1090, mmset, MMSET, nsd2, NSD2, reiibp, REIIBP, RGD1565590, si:rp71-77d7.2, trx5, TRX5, whs, WHS, WHSC1, Whsc1l, wu:fc12c04, wu:fi20c01Protein level used designations for WHSC1
- Wolf-Hirschhorn syndrome candidate 1 protein
- Wolf-Hirschhorn syndrome candidate 1
- probable histone-lysine N-methyltransferase NSD2
- IL5 promoter REII region-binding protein
- histone-lysine N-methyltransferase NSD2
- multiple myeloma SET domain containing protein type III
- nuclear SET domain-containing protein 2
- trithorax/ash1-related protein 5
- multiple myeloma SET domain-containing protein
- wolf-Hirschhorn syndrome candidate 1 protein homolog
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