WASP Products
(Wiskott-Aldrich Syndrome (Eczema-thrombocytopenia) (WAS))
Categories
The Wiskott-Aldrich syndrome (WAS) family of proteins share similar domain structure, and are involved in transduction of signals from receptors on the cell surface to the actin cytoskeleton. The presence of a number of different motifs suggests that they are regulated by a number of different stimuli, and interact with multiple proteins. Recent studies have demonstrated that these proteins, directly or indirectly, associate with the small GTPase, Cdc42, known to regulate formation of actin filaments, and the cytoskeletal organizing complex, Arp2/3. Wiskott-Aldrich syndrome is a rare, inherited, X-linked, recessive disease characterized by immune dysregulation and microthrombocytopenia, and is caused by mutations in the WAS gene. The WAS gene product is a cytoplasmic protein, expressed exclusively in hematopoietic cells, which show signalling and cytoskeletal abnormalities in WAS patients. A transcript variant arising as a result of alternative promoter usage, and containing a different 5' UTR sequence, has been described, however, its full-length nature is not known. [provided by RefSeq, Jul 2008].
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Featured WASP Categories
WASP Antibodies
High quality antibodies with extensive validation data.
WASP ELISA Kits
Reliable ELISA kits for a wide range of species.
WASP Proteins
Proteins for various applications incl. WB, ELISA, IF etc.
Recommended WASP Antibodies
Product
Reactivity
Application
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Human
Application
ELISA, IHC, FACS
Validations
- (6)
Cat. No.
ABIN5542679
Quantity
100 μL
Datasheet
Datasheet
Reactivity
Human
Application
WB, IF
Validations
- (5)
Cat. No.
ABIN7271381
Quantity
100 μL
Datasheet
Datasheet
Reactivity
Human
Application
WB, IHC, IP, ICC
Validations
- (4)
Cat. No.
ABIN7444415
Quantity
100 μL
Datasheet
Datasheet
Recommended WASP ELISA Kits
Product
Reactivity
Analytical Method
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Human, Mouse
Analytical Method
Qualitative Cell ELISA
Validations
Cat. No.
ABIN1380278
Quantity
2 x 96 tests
Datasheet
Datasheet
Recommended WASP Proteins
Product
Reactivity
Source
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Human
Source
Wheat germ
Validations
- (1)
Cat. No.
ABIN1325154
Quantity
10 μg
Datasheet
Datasheet
Reactivity
Human
Source
Escherichia coli (E. coli)
Validations
Cat. No.
ABIN7418293
Quantity
100 μg
Datasheet
Datasheet
Reactivity
Human
Source
Wheat germ
Validations
Cat. No.
ABIN1989806
Quantity
25 μg
Datasheet
Datasheet
Latest Publications for our WASP products
: "Essential role of Cdc42 in Ras-induced transformation revealed by gene targeting." in: PLoS ONE, Vol. 7, Issue 6, pp. e37317, (2012) (PubMed).: "HIV-1 activates Cdc42 and induces membrane extensions in immature dendritic cells to facilitate cell-to-cell virus propagation." in: Blood, Vol. 118, Issue 18, pp. 4841-52, (2011) (PubMed).
: "A balance of Bruton's tyrosine kinase and SHIP activation regulates B cell receptor cluster formation by controlling actin remodeling." in: Journal of immunology (Baltimore, Md. : 1950), Vol. 187, Issue 1, pp. 230-9, (2011) (PubMed).
: "Cdc42 regulates extracellular matrix remodeling in three dimensions." in: The Journal of biological chemistry, Vol. 286, Issue 42, pp. 36469-77, (2011) (PubMed).
: "Nonideal mixed micelles of fluorinated and hydrogenous surfactants in aqueous solution. NMR and SANS studies of anionic and nonionic systems." in: Langmuir : the ACS journal of surfaces and colloids, Vol. 26, Issue 8, pp. 5355-63, (2010) (PubMed).
: "Levels of Rabs and WAVE family proteins associated with translocation of GLUT4 to the cell surface in endometria from hyperinsulinemic PCOS women." in: Human reproduction (Oxford, England), Vol. 25, Issue 11, pp. 2870-7, (2010) (PubMed).
: "Coordination of IL-7 receptor and T-cell receptor signaling by cell-division cycle 42 in T-cell homeostasis." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 107, Issue 43, pp. 18505-10, (2010) (PubMed).
: "Regulation of podosome dynamics by WASp phosphorylation: implication in matrix degradation and chemotaxis in macrophages." in: Journal of cell science, Vol. 122, Issue Pt 21, pp. 3873-82, (2009) (PubMed).
: "Customised molecular diagnosis of primary immune deficiency disorders in New Zealand: an efficient strategy for a small developed country." in: The New Zealand medical journal, Vol. 122, Issue 1304, pp. 46-53, (2009) (PubMed).
: "Rho GTPase Cdc42 is essential for B-lymphocyte development and activation." in: Blood, Vol. 114, Issue 14, pp. 2909-16, (2009) (PubMed).
Synonyms and alternative names related to WASP
Wiskott-Aldrich syndrome (WAS), neural Wiskott-Aldrich syndrome protein (LOC5578888), wiskott-aldrich syndrome protein (CpipJ_CPIJ006699), Wiskott-Aldrich syndrome (Was), Wiskott-Aldrich syndrome L homeolog (was.L), Wiskott-Aldrich syndrome (eczema-thrombocytopenia) b (wasb), IMD2, imd2, SCNX, THC, thc, THC1, thc1, U42471, was, WASP, WASp, Wasp, wasp, wu:fk81c08, zgc:64164Protein level used designations for WASP
- eczema-thrombocytopenia
- thrombocytopenia 1 (X-linked)
- wiskott-Aldrich syndrome protein
- wiskott-aldrich syndrome protein
- Wiskott-Aldrich syndrome homolog
- wiskott-Aldrich syndrome protein homolog
- Wiskott-Aldrich syndrome (eczema-thrombocytopenia)
- Wiskott-Aldrich syndrome L homeolog
- wiskott-Aldrich syndrome L homeolog
- wasp1
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