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WASF1 Products

(WAS Protein Family, Member 1 (WASF1))
The protein encoded by this gene, a member of the Wiskott-Aldrich syndrome protein (WASP)-family, plays a critical role downstream of Rac, a Rho-family small GTPase, in regulating the actin cytoskeleton required for membrane ruffling. It has been shown to associate with an actin nucleation core Arp2/3 complex while enhancing actin polymerization in vitro. Wiskott-Aldrich syndrome is a disease of the immune system, likely due to defects in regulation of actin cytoskeleton. Multiple alternatively spliced transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Jul 2008].

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Featured WASF1 Categories

WASF1 Antibodies

High quality antibodies with extensive validation data.

WASF1 ELISA Kits

Reliable ELISA kits for a wide range of species.

WASF1 Proteins

Proteins for various applications incl. WB, ELISA, IF etc.

Recommended WASF1 Antibodies

Product
Reactivity
Application
Validations
Cat. No.
Quantity
Datasheet
Reactivity Human
Application WB, ELISA, IHC
Validations
  • (4)
Cat. No. ABIN7175830
Quantity 100 μg
Datasheet Datasheet
Reactivity Human, Mouse
Application WB, ELISA, IHC, IF, ICC
Validations
  • (3)
Cat. No. ABIN6266012
Quantity 100 μL
Datasheet Datasheet
Reactivity Human
Application WB, ELISA, IHC
Validations
  • (2)
Cat. No. ABIN7138927
Quantity 100 μL
Datasheet Datasheet

Recommended WASF1 ELISA Kits

Product
Reactivity
Analytical Method
Validations
Cat. No.
Quantity
Datasheet
Reactivity Human, Mouse, Rat
Analytical Method Qualitative Cell ELISA
Validations
Cat. No. ABIN1380279
Quantity 2 x 96 tests
Datasheet Datasheet

Recommended WASF1 Proteins

Product
Reactivity
Source
Validations
Cat. No.
Quantity
Datasheet
Reactivity Human
Source Wheat germ
Validations
  • (1)
Cat. No. ABIN1325156
Quantity 10 μg
Datasheet Datasheet
Reactivity Human
Source Tobacco (Nicotiana tabacum)
Validations
Cat. No. ABIN3075433
Quantity 1 mg
Datasheet Datasheet
Reactivity Rat
Source Yeast
Validations
Cat. No. ABIN1630881
Quantity 1 mg
Datasheet Datasheet

Latest Publications for our WASF1 products

Chazeau, Mehidi, Nair, Gautier, Leduc, Chamma, Kage, Kechkar, Thoumine, Rottner, Choquet, Gautreau, Sibarita, Giannone: "Nanoscale segregation of actin nucleation and elongation factors determines dendritic spine protrusion." in: The EMBO journal, Vol. 33, Issue 23, pp. 2745-64, (2014) (PubMed).

Chen, Brinkmann, Chen, Pak, Liao, Shi, Henry, Grishin, Bogdan, Rosen: "The WAVE regulatory complex links diverse receptors to the actin cytoskeleton." in: Cell, Vol. 156, Issue 1-2, pp. 195-207, (2014) (PubMed).

Chia, Chen, Li, Rosen, Shen: "Local F-actin network links synapse formation and axon branching." in: Cell, Vol. 156, Issue 1-2, pp. 208-20, (2014) (PubMed).

Han, Holder, Schaaf, Lu, Chen, Kang, Tang, Wu, Hao, Cheung, Yu, Sun, Breman, Patel, Lu, Zoghbi: "SHANK3 overexpression causes manic-like behaviour with unique pharmacogenetic properties." in: Nature, Vol. 503, Issue 7474, pp. 72-7, (2013) (PubMed).

Karpushev, Levchenko, Ilatovskaya, Pavlov, Staruschenko: "Novel role of Rac1/WAVE signaling mechanism in regulation of the epithelial Na+ channel." in: Hypertension (Dallas, Tex. : 1979), Vol. 57, Issue 5, pp. 996-1002, (2011) (PubMed).

Tahirovic, Hellal, Neukirchen, Hindges, Garvalov, Flynn, Stradal, Chrostek-Grashoff, Brakebusch, Bradke: "Rac1 regulates neuronal polarization through the WAVE complex." in: The Journal of neuroscience : the official journal of the Society for Neuroscience, Vol. 30, Issue 20, pp. 6930-43, (2010) (PubMed).

Khodosevich, Seeburg, Monyer: "Major signaling pathways in migrating neuroblasts." in: Frontiers in molecular neuroscience, Vol. 2, pp. 7, (2009) (PubMed).

Beli, Mascheroni, Xu, Innocenti: "WAVE and Arp2/3 jointly inhibit filopodium formation by entering into a complex with mDia2." in: Nature cell biology, Vol. 10, Issue 7, pp. 849-57, (2008) (PubMed).

Cheng, Arumugam, Liu, Khatri, Mustafa, Kwak, Ling, Gonzales, Xin, Jo, Guo, Mark, Mattson: "Pancortin-2 interacts with WAVE1 and Bcl-xL in a mitochondria-associated protein complex that mediates ischemic neuronal death." in: The Journal of neuroscience : the official journal of the Society for Neuroscience, Vol. 27, Issue 7, pp. 1519-28, (2007) (PubMed).

Ardern, Sandilands, Machesky, Timpson, Frame, Brunton: "Src-dependent phosphorylation of Scar1 promotes its association with the Arp2/3 complex." in: Cell motility and the cytoskeleton, Vol. 63, Issue 1, pp. 6-13, (2006) (PubMed).

Synonyms and alternative names related to WASF1

WAS protein family member 1 S homeolog (wasf1.S), SCAR family protein (AT2G34150), WAS protein family member 1 (wasf1), WAS protein family member 1 (WASF1), WAS protein family, member 1 (Wasf1), AI195380, AI838537, ATRANGAP2, ATSCAR1, Scar, scar1, SCAR1, T14G11.27, T14G11_27, wave, WAVE, WAVE-1, wave1, WAVE1, WISKOTT-ALDRICH SYNDROME PROTEIN FAMILY VERPROLIN HOMOLOGOUS PROTEIN 1

Protein level used designations for WASF1

  • WASP family protein member 1
  • homology of dictyostelium scar 1
  • protein WAVE-1
  • verprolin homology domain-containing protein 1
  • wiskott-Aldrich syndrome protein family member 1
  • WASP family 1
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