VHL Products
(Von Hippel-Lindau Tumor Suppressor, E3 Ubiquitin Protein Ligase (VHL))
Categories
Von Hippel-Lindau syndrome (VHL) is a dominantly inherited familial cancer syndrome predisposing to a variety of malignant and benign tumors. A germline mutation of this gene is the basis of familial inheritance of VHL syndrome. The protein encoded by this gene is a component of the protein complex that includes elongin B, elongin C, and cullin-2, and possesses ubiquitin ligase E3 activity. This protein is involved in the ubiquitination and degradation of hypoxia-inducible-factor (HIF), which is a transcription factor that plays a central role in the regulation of gene expression by oxygen. RNA polymerase II subunit POLR2G/RPB7 is also reported to be a target of this protein. Alternatively spliced transcript variants encoding distinct isoforms have been observed. [provided by RefSeq, Jul 2008].
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Featured VHL Categories
VHL Antibodies
High quality antibodies with extensive validation data.
VHL ELISA Kits
Reliable ELISA kits for a wide range of species.
VHL Proteins
Proteins for various applications incl. WB, ELISA, IF etc.
Recommended VHL Antibodies
Product
Reactivity
Application
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Human
Application
WB, IF, IHC (p), IP, ICC
Validations
- (1)
- (8)
Cat. No.
ABIN2854928
Quantity
100 μL
Datasheet
Datasheet
Reactivity
Human
Application
WB, IHC, IF
Validations
- (3)
- (6)
Cat. No.
ABIN3020968
Quantity
100 μL
Datasheet
Datasheet
Reactivity
Human, Mouse
Application
WB, FACS, IF, IHC (p)
Validations
- (7)
Cat. No.
ABIN390462
Quantity
200 μL
Datasheet
Datasheet
Recommended VHL ELISA Kits
Product
Reactivity
Analytical Method
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Human
Analytical Method
Quantitative Sandwich ELISA
Validations
- (1)
Cat. No.
ABIN6971170
Quantity
96 tests
Datasheet
Datasheet
Reactivity
Rat
Analytical Method
Quantitative Sandwich ELISA
Validations
- (1)
Cat. No.
ABIN6960511
Quantity
96 tests
Datasheet
Datasheet
Reactivity
Human
Analytical Method
Quantitative Sandwich ELISA
Validations
- (1)
Cat. No.
ABIN5518585
Quantity
96 tests
Datasheet
Datasheet
Recommended VHL Proteins
Product
Reactivity
Source
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Human
Source
Wheat germ
Validations
- (1)
- (1)
Cat. No.
ABIN1325000
Quantity
10 μg
Datasheet
Datasheet
Reactivity
Human
Source
Escherichia coli (E. coli)
Validations
Cat. No.
ABIN2132533
Quantity
100 μg
Datasheet
Datasheet
Reactivity
Human
Source
Escherichia coli (E. coli)
Validations
Cat. No.
ABIN7424887
Quantity
100 μg
Datasheet
Datasheet
Latest Publications for our VHL products
: "Protective effect of salidroside against bone loss via hypoxia-inducible factor-1α pathway-induced angiogenesis." in: Scientific reports, Vol. 6, pp. 32131, (2018) (PubMed).: "VHL deficiency augments anthracycline sensitivity of clear cell renal cell carcinomas by down-regulating ALDH2." in: Nature communications, Vol. 8, pp. 15337, (2018) (PubMed).
: "Salidroside accelerates fracture healing through cell-autonomous and non-autonomous effects on osteoblasts." in: Cell and tissue research, Vol. 367, Issue 2, pp. 197-211, (2017) (PubMed).
: "Forkhead Transcription Factor 3a (FOXO3a) Modulates Hypoxia Signaling via Up-regulation of the von Hippel-Lindau Gene (VHL)." in: The Journal of biological chemistry, Vol. 291, Issue 49, pp. 25692-25705, (2017) (PubMed).
: "An ID2-dependent mechanism for VHL inactivation in cancer." in: Nature, Vol. 529, Issue 7585, pp. 172-7, (2016) (PubMed).
: "WSB1 promotes tumor metastasis by inducing pVHL degradation." in: Genes & development, Vol. 29, Issue 21, pp. 2244-57, (2015) (PubMed).
: "Jumonji Domain Containing Protein 6: A Novel Oxygen Sensor in the Human Placenta." in: Endocrinology, Vol. 156, Issue 8, pp. 3012-25, (2015) (PubMed).
: "HIF-1α disturbs osteoblasts and osteoclasts coupling in bone remodeling by up-regulating OPG expression." in: In vitro cellular & developmental biology. Animal, Vol. 51, Issue 8, pp. 808-14, (2015) (PubMed).
: "Oncotropic H-1 parvovirus infection degrades HIF-1α protein in human pancreatic cancer cells independently of VHL and RACK1." in: International journal of oncology, Vol. 46, Issue 5, pp. 2076-82, (2015) (PubMed).
: "pVHL Negatively Regulates Antiviral Signaling by Targeting MAVS for Proteasomal Degradation." in: Journal of immunology (Baltimore, Md. : 1950), Vol. 195, Issue 4, pp. 1782-90, (2015) (PubMed).
Synonyms and alternative names related to VHL
von Hippel-Lindau tumor suppressor (VHL), von Hippel-Lindau (Vhl), von Hippel-Lindau tumor suppressor (vhl), von Hippel-Lindau tumor suppressor, E3 ubiquitin protein ligase (VHL), von Hippel-Lindau disease tumor suppressor (CpipJ_CPIJ009992), von Hippel-Lindau tumor suppressor (Vhl), BcDNA:RH61560, CG13221, d-VHL, d-vhl, Dmel\\CG13221, dmVHL, DVhl, Dvhl, dVHL, HRCA1, hrca1, pVHL, RCA1, rca1, VHL, vhl, VHL1, vhl1, Vhlh, zgc:158722Protein level used designations for VHL
- elongin binding protein
- protein G7
- von Hippel-Lindau disease tumor suppressor
- CG13221-PA
- CG13221-PB
- Vhl-PA
- Vhl-PB
- von hippel lindau
- von hippel lindau protein
- pVHL
- von Hippel-Lindau tumor suppressor
- von Hippel-Lindau syndrome homolog
- von Hippel-Lindau syndrome protein homolog
- Von Hippel-Lindau disease tumor suppressor
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