USP8 Products
(Ubiquitin Specific Peptidase 8 (USP8))
Categories
Hydrolase that can remove conjugated ubiquitin from proteins and therefore plays an important regulatory role at the level of protein turnover by preventing degradation. Converts both 'Lys-48' an 'Lys-63'-linked ubiquitin chains. Catalytic activity is enhanced in the M phase. Involved in cell proliferation. Required to enter into S phase in response to serum stimulation. May regulate T-cell anergy mediated by RNF128 via the formation of a complex containing RNF128 and OTUB1. Probably regulates the stability of STAM2 and RASGRF1. Regulates endosomal ubiquitin dynamics, cargo sorting, membrane traffic at early endosomes, and maintenance of ESCRT-0 stability. The level of protein ubiquitination on endosomes is essential for maintaining the morphology of the organelle. Deubiquitinates EPS15 and controles tyrosine kinase stability. Removes conjugated ubiquitin from EGFR thus regulating EGFR degradation and downstream MAPK signaling. Involved in acrosome biogenesis through interaction with the spermatid ESCRT-0 complex and microtubules. Deubiquitinates BIRC6/bruce and KIF23/MKLP1.
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Featured USP8 Categories
USP8 Antibodies
High quality antibodies with extensive validation data.
USP8 ELISA Kits
Reliable ELISA kits for a wide range of species.
USP8 Proteins
Proteins for various applications incl. WB, ELISA, IF etc.
Recommended USP8 Antibodies
Product
Reactivity
Application
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Human
Application
WB, IF, IHC (p), IP, ICC
Validations
- (4)
Cat. No.
ABIN2855692
Quantity
100 μL
Datasheet
Datasheet
Reactivity
Human
Application
WB, IHC, ELISA
Validations
- (2)
Cat. No.
ABIN7174360
Quantity
100 μL
Datasheet
Datasheet
Reactivity
Human
Application
WB, IHC (p)
Validations
- (2)
Cat. No.
ABIN388891
Quantity
400 μL
Datasheet
Datasheet
Recommended USP8 ELISA Kits
Product
Reactivity
Analytical Method
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Human
Analytical Method
Quantitative Sandwich ELISA
Validations
- (1)
Cat. No.
ABIN6960352
Quantity
96 tests
Datasheet
Datasheet
Reactivity
Human
Analytical Method
Quantitative Sandwich ELISA
Validations
- (2)
Cat. No.
ABIN1117711
Quantity
96 tests
Datasheet
Datasheet
Reactivity
Human
Analytical Method
Quantitative Sandwich ELISA
Validations
- (1)
Cat. No.
ABIN1573011
Quantity
96 tests
Datasheet
Datasheet
Recommended USP8 Proteins
Product
Reactivity
Source
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Human
Source
Escherichia coli (E. coli)
Validations
- (1)
Cat. No.
ABIN7125599
Quantity
50 μg
Datasheet
Datasheet
Reactivity
Human
Source
Escherichia coli (E. coli)
Validations
Cat. No.
ABIN7398275
Quantity
100 μg
Datasheet
Datasheet
Reactivity
Human
Source
Tobacco (Nicotiana tabacum)
Validations
Cat. No.
ABIN3096238
Quantity
1 mg
Datasheet
Datasheet
Latest Publications for our USP8 products
: "Oncogenic PIK3CA mutations reprogram glutamine metabolism in colorectal cancer. ..." in: Nature communications, Vol. 7, pp. 11971, (2016) (PubMed).: "Mutations in the deubiquitinase gene USP8 cause Cushing's disease." in: Nature genetics, Vol. 47, Issue 1, pp. 31-8, (2014) (PubMed).
: "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. ..." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 99, Issue 26, pp. 16899-903, (2002) (PubMed).
: "Ras-GAP SH3 domain binding protein (G3BP) is a modulator of USP10, a novel human ubiquitin specific protease." in: Oncogene, Vol. 20, Issue 29, pp. 3869-79, (2001) (PubMed).
Synonyms and alternative names related to USP8
ubiquitin carboxyl-terminal hydrolase 8 (LOC9310109), ubiquitin carboxyl-terminal hydrolase 8 (MGYG_00369), ubiquitin specific peptidase 8 (USP8), ubiquitin specific peptidase 8 (Usp8), AI574262, AW557536, HumORF8, mKIAA0055, UBPY, UbpyProtein level used designations for USP8
- ubiquitin carboxyl-terminal hydrolase 8
- ubiquitin-specific-processing protease 8
- ubiquitin specific peptidase 8
- ubiquitin carboxyl-terminal hydrolase 8-like
- deubiquitinating enzyme 8
- hUBPy
- ubiquitin isopeptidase Y
- ubiquitin specific protease 8
- ubiquitin thioesterase 8
- ubiquitin thiolesterase 8
- putative deubiquitinating enzyme
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