UPF3A Products
(UPF3 Regulator of Nonsense Transcripts Homolog A (UPF3A))
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This gene encodes a protein that is part of a post-splicing multiprotein complex involved in both mRNA nuclear export and mRNA surveillance. The encoded protein is one of two functional homologs to yeast Upf3p. mRNA surveillance detects exported mRNAs with truncated open reading frames and initiates nonsense-mediated mRNA decay (NMD). When translation ends upstream from the last exon-exon junction, this triggers NMD to degrade mRNAs containing premature stop codons. This protein binds to the mRNA and remains bound after nuclear export, acting as a nucleocytoplasmic shuttling protein. It forms with Y14 a complex that binds specifically 20 nt upstream of exon-exon junctions. This gene is located on the long arm of chromosome 13. Two splice variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008].
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Featured UPF3A Categories
UPF3A Antibodies
High quality antibodies with extensive validation data.
UPF3A Proteins
Proteins for various applications incl. WB, ELISA, IF etc.
Recommended UPF3A Antibodies
Product
Reactivity
Application
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Human
Application
WB, ELISA, IHC (p)
Validations
- (4)
Cat. No.
ABIN528787
Quantity
100 μg
Datasheet
Datasheet
Reactivity
Human
Application
WB, IF
Validations
- (4)
Cat. No.
ABIN7271227
Quantity
100 μL
Datasheet
Datasheet
Reactivity
Human
Application
WB, IF
Validations
- (2)
Cat. No.
ABIN528786
Quantity
50 μg
Datasheet
Datasheet
Recommended UPF3A ELISA Kits
Product
Reactivity
Analytical Method
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Human
Analytical Method
Quantitative Sandwich ELISA
Validations
Cat. No.
ABIN6208301
Quantity
96 tests
Datasheet
Datasheet
Recommended UPF3A Proteins
Product
Reactivity
Source
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Human
Source
Wheat germ
Validations
- (1)
Cat. No.
ABIN1324686
Quantity
10 μg
Datasheet
Datasheet
Reactivity
Human
Source
Wheat germ
Validations
- (1)
Cat. No.
ABIN1324688
Quantity
10 μg
Datasheet
Datasheet
Reactivity
Human
Source
HEK-293 Cells
Validations
- (1)
Cat. No.
ABIN2735036
Quantity
20 μg
Datasheet
Datasheet
Latest Publications for our UPF3A products
: "Mutations in UPF3B, a member of the nonsense-mediated mRNA decay complex, cause syndromic and nonsyndromic mental retardation. ..." in: Nature genetics, Vol. 39, Issue 9, pp. 1127-33, (2007) (PubMed).Synonyms and alternative names related to UPF3A
UPF3 regulator of nonsense transcripts homolog A (yeast) (Upf3a), UPF3A, regulator of nonsense mediated mRNA decay (Upf3a), UPF3 regulator of nonsense transcripts homolog A (yeast) (UPF3A), UPF3A, regulator of nonsense mediated mRNA decay (UPF3A), UPF3A, regulator of nonsense mediated mRNA decay (upf3a), 2600001C03Rik, 4930546M19Rik, HUPF3A, RENT3A, si:dkey-21o13.6, UPF3, UPF3AProtein level used designations for UPF3A
- UPF3 regulator of nonsense transcripts homolog A
- regulator of nonsense transcripts 3A
- UPF3 regulator of nonsense transcripts homolog A (yeast)
- regulator of nonsense transcripts 3A-like
- hUpf3
- nonsense mRNA reducing factor 3A
- up-frameshift suppressor 3 homolog A
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