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UNC13D Products

(Unc-13 Homolog D (UNC13D))

Categories

This gene encodes an RGD-containing protein that binds to type I, II and IV collagens. The RGD motif is found in many extracellular matrix proteins modulating cell adhesion and serves as a ligand recognition sequence for several integrins. This protein plays a role in cell-collagen interactions and may be involved in endochondrial bone formation in cartilage. The protein is induced by transforming growth factor-beta and acts to inhibit cell adhesion. Mutations in this gene are associated with multiple types of corneal dystrophy. [provided by RefSeq, Jul 2008].

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Featured UNC13D Categories

UNC13D Antibodies

High quality antibodies with extensive validation data.

UNC13D Proteins

Proteins for various applications incl. WB, ELISA, IF etc.

Recommended UNC13D Antibodies

Product
Reactivity
Application
Validations
Cat. No.
Quantity
Datasheet
Reactivity Human
Application WB, ELISA
Validations
  • (4)
Cat. No. ABIN531286
Quantity 100 μg
Datasheet Datasheet
Reactivity Human, Mouse
Application WB, ELISA, IHC
Validations
  • (3)
Cat. No. ABIN185677
Quantity 100 μg
Datasheet Datasheet
Reactivity Human
Application WB, IF, IHC (p), ICC
Validations
  • (3)
Cat. No. ABIN2856569
Quantity 100 μL
Datasheet Datasheet

Recommended UNC13D ELISA Kits

Product
Reactivity
Analytical Method
Validations
Cat. No.
Quantity
Datasheet
Reactivity Human
Analytical Method Quantitative Sandwich ELISA
Validations
Cat. No. ABIN6219996
Quantity 96 tests
Datasheet Datasheet

Recommended UNC13D Proteins

Product
Reactivity
Source
Validations
Cat. No.
Quantity
Datasheet
Reactivity Human
Source Wheat germ
Validations
  • (1)
Cat. No. ABIN1324647
Quantity 10 μg
Datasheet Datasheet
Reactivity Human
Source Tobacco (Nicotiana tabacum)
Validations
Cat. No. ABIN3096260
Quantity 1 mg
Datasheet Datasheet
Reactivity Human
Source HEK-293 Cells
Validations
  • (1)
Cat. No. ABIN2735014
Quantity 20 μg
Datasheet Datasheet

Latest Publications for our UNC13D products

Messenger, Woo, Sun, Martin: "A Ca2+-stimulated exosome release pathway in cancer cells is regulated by Munc13-4." in: The Journal of cell biology, Vol. 217, Issue 8, pp. 2877-2890, (2018) (PubMed).

Woo, James, Martin: "Munc13-4 functions as a Ca(2+) sensor for homotypic secretory granule fusion to generate endosomal exocytic vacuoles." in: Molecular biology of the cell, Vol. 28, Issue 6, pp. 792-808, (2017) (PubMed).

Man, Imig, Walter, Pinheiro, Stevens, Rettig, Sørensen, Cooper, Brose, Wojcik: "Identification of a Munc13-sensitive step in chromaffin cell large dense-core vesicle exocytosis." in: eLife, Vol. 4, (2016) (PubMed).

Zur Stadt, Beutel, Kolberg, Schneppenheim, Kabisch, Janka, Hennies: "Mutation spectrum in children with primary hemophagocytic lymphohistiocytosis: molecular and functional analyses of PRF1, UNC13D, STX11, and RAB27A." in: Human mutation, Vol. 27, Issue 1, pp. 62-8, (2005) (PubMed).

Feldmann, Callebaut, Raposo, Certain, Bacq, Dumont, Lambert, Ouachée-Chardin, Chedeville, Tamary, Minard-Colin, Vilmer, Blanche, Le Deist, Fischer, de Saint Basile: "Munc13-4 is essential for cytolytic granules fusion and is mutated in a form of familial hemophagocytic lymphohistiocytosis (FHL3)." in: Cell, Vol. 115, Issue 4, pp. 461-73, (2003) (PubMed).

Synonyms and alternative names related to UNC13D

unc-13 homolog D (UNC13D), unc-13 homolog D (C. elegans) (Unc13d), unc-13 homolog D (Unc13d), transforming growth factor beta induced (TGFBI), unc-13 homolog D (unc13d), unc-13 homolog D (un13d), 2610108D09Rik, BIGH3, CDB1, CDG2, CDGG1, CSD, CSD1, CSD2, CSD3, EBMD, FHL3, HLH3, HPLH3, Jinx, LCD1, mFLJ00067, Munc13-4, UNC13D, Unc13h4

Protein level used designations for UNC13D

  • protein unc-13 homolog D
  • unc-13 homolog D (C. elegans)
  • likely ortholog of H. sapiens unc-13 homolog D (UNC13D)
  • RGD-CAP
  • RGD-containing collagen-associated protein
  • beta ig-h3
  • kerato-epithelin
  • transforming growth factor-beta-induced protein ig-h3
  • protein unc-13 homolog D-like
  • unc-13 homolog D
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