UHRF1 Products
(Ubiquitin-Like, Containing PHD and RING Finger Domains, 1 (UHRF1))
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This gene encodes a member of a subfamily of RING-finger type E3 ubiquitin ligases. The protein binds to specific DNA sequences, and recruits a histone deacetylase to regulate gene expression. Its expression peaks at late G1 phase and continues during G2 and M phases of the cell cycle. It plays a major role in the G1/S transition by regulating topoisomerase IIalpha and retinoblastoma gene expression, and functions in the p53-dependent DNA damage checkpoint. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008].
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Featured UHRF1 Categories
UHRF1 Antibodies
High quality antibodies with extensive validation data.
UHRF1 Proteins
Proteins for various applications incl. WB, ELISA, IF etc.
Recommended UHRF1 Antibodies
Product
Reactivity
Application
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Human
Application
WB, ELISA, IHC, ICC, FACS
Validations
- (9)
Cat. No.
ABIN5542545
Quantity
100 μL
Datasheet
Datasheet
Reactivity
Human
Application
WB, IF, IHC
Validations
- (7)
Cat. No.
ABIN3023232
Quantity
100 μL
Datasheet
Datasheet
Reactivity
Human
Application
WB, ELISA, IHC
Validations
- (5)
Cat. No.
ABIN5542544
Quantity
100 μL
Datasheet
Datasheet
Recommended UHRF1 ELISA Kits
Product
Reactivity
Analytical Method
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Human
Analytical Method
Quantitative Sandwich ELISA
Validations
- (1)
Cat. No.
ABIN6971052
Quantity
96 tests
Datasheet
Datasheet
Recommended UHRF1 Proteins
Product
Reactivity
Source
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Human
Source
Escherichia coli (E. coli)
Validations
- (1)
Cat. No.
ABIN7125644
Quantity
50 μg
Datasheet
Datasheet
Reactivity
Human
Source
Wheat germ
Validations
- (1)
Cat. No.
ABIN1324607
Quantity
10 μg
Datasheet
Datasheet
Reactivity
Human
Source
Wheat germ
Validations
Cat. No.
ABIN1324606
Quantity
25 μg
Datasheet
Datasheet
Latest Publications for our UHRF1 products
: "Transcription factor ICBP90 regulates the MIF promoter and immune susceptibility locus." in: The Journal of clinical investigation, Vol. 126, Issue 2, pp. 732-44, (2016) (PubMed).: "Inhibiting UHRF1 expression enhances radiosensitivity in human esophageal squamous cell carcinoma." in: Molecular biology reports, Vol. 40, Issue 9, pp. 5225-35, (2013) (PubMed).
: "M phase phosphorylation of the epigenetic regulator UHRF1 regulates its physical association with the deubiquitylase USP7 and stability." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 109, Issue 13, pp. 4828-33, (2012) (PubMed).
: "The USP7/Dnmt1 complex stimulates the DNA methylation activity of Dnmt1 and regulates the stability of UHRF1." in: Nucleic acids research, Vol. 39, Issue 19, pp. 8355-65, (2011) (PubMed).
: "DNMT1 stability is regulated by proteins coordinating deubiquitination and acetylation-driven ubiquitination." in: Science signaling, Vol. 3, Issue 146, pp. ra80, (2010) (PubMed).
: "Interplay between Np95 and Eme1 in the DNA damage response." in: Biochemical and biophysical research communications, Vol. 375, Issue 3, pp. 321-5, (2008) (PubMed).
: "Genomic structure and chromosomal mapping of the gene coding for ICBP90, a protein involved in the regulation of the topoisomerase IIalpha gene expression." in: Gene, Vol. 266, Issue 1-2, pp. 15-23, (2001) (PubMed).
: "ICBP90, a novel human CCAAT binding protein, involved in the regulation of topoisomerase IIalpha expression." in: Cancer research, Vol. 60, Issue 1, pp. 121-8, (2000) (PubMed).
Synonyms and alternative names related to UHRF1
ubiquitin like with PHD and ring finger domains 1 (UHRF1), ubiquitin-like, containing PHD and RING finger domains, 1 (Uhrf1), ubiquitin-like with PHD and ring finger domains 1 (Uhrf1), ubiquitin-like with PHD and ring finger domains 1 (uhrf1), ubiquitin like with PHD and ring finger domains 1 (Uhrf1), AL022808, fb97f09, hNP95, hUHRF1, ICBP90, Np95, NP95, RNF106, UHRF1, wu:fb97f09, zgc:63539Protein level used designations for UHRF1
- E3 ubiquitin-protein ligase UHRF1
- RING finger protein 106
- huNp95
- inverted CCAAT box-binding protein of 90 kDa
- nuclear protein 95
- nuclear zinc finger protein Np95
- transcription factor ICBP90
- ubiquitin-like PHD and RING finger domain-containing protein 1
- ubiquitin-like, containing PHD and RING finger domains, 1
- ubiquitin-like-containing PHD and RING finger domains protein 1
- mUhrf1
- liver regeneration-related protein LRRG126
- ubiquitin-like with PHD and ring finger domains 1
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