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UGT1A8 Protein (Myc-DYKDDDDK Tag)

UGT1A8 Origin: Human Host: HEK-293 Cells Recombinant > 80 % as determined by SDS-PAGE and Coomassie blue staining AbP, STD
Catalog No. ABIN2734969
  • Target
    UGT1A8 (UDP Glucuronosyltransferase 1 Family, Polypeptide A8 (UGT1A8))
    Protein Type
    Recombinant
    Origin
    Human
    Source
    HEK-293 Cells
    Purification tag / Conjugate
    This UGT1A8 protein is labelled with Myc-DYKDDDDK Tag.
    Application
    Antibody Production (AbP), Standard (STD)
    Characteristics
    • Recombinant human UDP glucuronosyltransferase 1 family, polypeptide A8 (UGT1A8) protein expressed in HEK293 cells.
    • Produced with end-sequenced ORF clone
    Purity
    > 80 % as determined by SDS-PAGE and Coomassie blue staining
  • Application Notes
    Recombinant human proteins can be used for:
    Native antigens for optimized antibody production
    Positive controls in ELISA and other antibody assays
    Comment

    The tag is located at the C-terminal.

    Restrictions
    For Research Use only
  • Concentration
    50 μg/mL
    Buffer
    25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10 % glycerol.
    Storage
    -80 °C
    Storage Comment
    Store at -80°C. Thaw on ice, aliquot to individual single-use tubes, and then re-freeze immediately. Only 2-3 freeze thaw cycles are recommended.
  • Target
    UGT1A8 (UDP Glucuronosyltransferase 1 Family, Polypeptide A8 (UGT1A8))
    Synonyms
    UDPGT Protein, UDPGT 1-8 Protein, UGT-1H Protein, UGT1-08 Protein, UGT1.8 Protein, UGT1A8S Protein, UGT1H Protein, A116 Protein, OTTMUSG00000020811 Protein, Ugt1 Protein, Ugt1a9 Protein, UDP glucuronosyltransferase 1 family, polypeptide A8 Protein, UDP glucuronosyltransferase family 1 member A8 Protein, UDP glycosyltransferase 1 family, polypeptide A8 Protein, UGT1A8 Protein, Ugt1a8 Protein
    Background
    This gene encodes a UDP-glucuronosyltransferase, an enzyme of the glucuronidation pathway that transforms small lipophilic molecules, such as steroids, bilirubin, hormones, and drugs, into water-soluble, excretable metabolites. This gene is part of a complex locus that encodes several UDP-glucuronosyltransferases. The locus includes thirteen unique alternate first exons followed by four common exons. Four of the alternate first exons are considered pseudogenes. Each of the remaining nine 5&apos exons may be spliced to the four common exons, resulting in nine proteins with different N-termini and identical C-termini. Each first exon encodes the substrate binding site, and is regulated by its own promoter. The enzyme encoded by this gene has glucuronidase activity with many substrates including coumarins, phenols, anthraquinones, flavones, and some opioids.
    Molecular Weight
    57.1 kDa
    NCBI Accession
    NP_061949
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