UCP2 Products
(Uncoupling Protein 2 (Mitochondrial, Proton Carrier) (UCP2))
Categories
Mitochondrial uncoupling proteins (UCP) are members of the larger family of mitochondrial anion carrier proteins (MACP). UCPs separate oxidative phosphorylation from ATP synthesis with energy dissipated as heat, also referred to as the mitochondrial proton leak. UCPs facilitate the transfer of anions from the inner to the outer mitochondrial membrane and the return transfer of protons from the outer to the inner mitochondrial membrane. They also reduce the mitochondrial membrane potential in mammalian cells. Tissue specificity occurs for the different UCPs and the exact methods of how UCPs transfer H+/OH- are not known. UCPs contain the three homologous protein domains of MACPs. This gene is expressed in many tissues, with the greatest expression in skeletal muscle. It is thought to play a role in nonshivering thermogenesis, obesity and diabetes. Chromosomal order is 5'-UCP3-UCP2-3'. [provided by RefSeq, Jul 2008].
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Featured UCP2 Categories
UCP2 Antibodies
High quality antibodies with extensive validation data.
UCP2 ELISA Kits
Reliable ELISA kits for a wide range of species.
UCP2 Proteins
Proteins for various applications incl. WB, ELISA, IF etc.
Recommended UCP2 Antibodies
Product
Reactivity
Application
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Human, Mouse, Rat
Application
WB, ELISA, IF
Validations
- (7)
Cat. No.
ABIN5539644
Quantity
100 μg
Datasheet
Datasheet
Reactivity
Human
Application
WB, IHC, IP, ICC
Validations
- (5)
Cat. No.
ABIN7428086
Quantity
100 μL
Datasheet
Datasheet
Reactivity
Rat
Application
WB, IHC, IP, ICC
Validations
- (5)
Cat. No.
ABIN7435031
Quantity
100 μL
Datasheet
Datasheet
Recommended UCP2 ELISA Kits
Product
Reactivity
Analytical Method
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Human
Analytical Method
Quantitative Sandwich ELISA
Validations
- (1)
- (1)
Cat. No.
ABIN6971067
Quantity
96 tests
Datasheet
Datasheet
Reactivity
Human
Analytical Method
Quantitative Sandwich ELISA
Validations
- (1)
- (1)
Cat. No.
ABIN6960374
Quantity
96 tests
Datasheet
Datasheet
Reactivity
Rat
Analytical Method
Quantitative Sandwich ELISA
Validations
- (2)
- (1)
Cat. No.
ABIN6960376
Quantity
96 tests
Datasheet
Datasheet
Recommended UCP2 Proteins
Product
Reactivity
Source
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Human
Source
Wheat germ
Validations
- (1)
Cat. No.
ABIN1324536
Quantity
25 μg
Datasheet
Datasheet
Reactivity
Human
Source
Escherichia coli (E. coli)
Validations
Cat. No.
ABIN7396562
Quantity
100 μg
Datasheet
Datasheet
Reactivity
Mouse
Source
Escherichia coli (E. coli)
Validations
Cat. No.
ABIN7402316
Quantity
100 μg
Datasheet
Datasheet
Latest Publications for our UCP2 products
: "Dose-dependent reproductive toxicity of sodium benzoate in male rats: Inflammation, oxidative stress and apoptosis." in: Reproductive toxicology (Elmsford, N.Y.), Vol. 98, pp. 92-98, (2020) (PubMed).: "Significant Association Between Low Mitochondrial DNA Content in Peripheral Blood Leukocytes and Ischemic Stroke." in: Journal of the American Heart Association, Vol. 6, Issue 11, (2018) (PubMed).
: "Vitamin C and E chronic supplementation differentially affect hepatic insulin signaling in rats." in: Life sciences, Vol. 194, pp. 196-204, (2018) (PubMed).
: "The effect of delivery type on uncoupling protein-2 levels." in: The journal of maternal-fetal & neonatal medicine, Vol. 29, Issue 18, pp. 2940-3, (2016) (PubMed).
: "Methylglyoxal Impairs Insulin Secretion of Pancreatic β-Cells through Increased Production of ROS and Mitochondrial Dysfunction Mediated by Upregulation of UCP2 and MAPKs." in: Journal of diabetes research, Vol. 2016, pp. 2029854, (2016) (PubMed).
: "Onconase induces autophagy sensitizing pancreatic cancer cells to gemcitabine and activates Akt/mTOR pathway in a ROS-dependent manner." in: Biochimica et biophysica acta, Vol. 1853, Issue 3, pp. 549-60, (2015) (PubMed).
: "The mitochondrial uncoupling protein-2 is a master regulator of both M1 and M2 microglial responses." in: Journal of neurochemistry, Vol. 135, Issue 1, pp. 147-56, (2015) (PubMed).
: "Defective mitophagy in XPA via PARP-1 hyperactivation and NAD(+)/SIRT1 reduction." in: Cell, Vol. 157, Issue 4, pp. 882-96, (2014) (PubMed).
: "S-adenosyl methionine prevents endothelial dysfunction by inducing heme oxygenase-1 in vascular endothelial cells." in: Molecules and cells, Vol. 36, Issue 4, pp. 376-84, (2014) (PubMed).
: "Tempol protects cardiomyocytes from nucleoside reverse transcriptase inhibitor-induced mitochondrial toxicity." in: Toxicological sciences : an official journal of the Society of Toxicology, Vol. 139, Issue 1, pp. 133-41, (2014) (PubMed).
Synonyms and alternative names related to UCP2
mitochondrial uncoupling protein 2 (PTRG_09289), uncoupling protein 2 (UCP2), mitochondrial uncoupling protein 2 (LOC100282746), uncoupling protein 2 (mitochondrial, proton carrier) L homeolog (ucp2.L), uncoupling protein 2 (mitochondrial, proton carrier) (ucp2), uncoupling protein 2 (ucp2), uncoupling protein 1 (ucp1), uncoupling protein 2 (mitochondrial, proton carrier) (Ucp2), uncoupling protein 2 (Ucp2), ATUCP2, BMIQ4, cb74, DKFZp470P1633, K19M22.21, K19M22_21, MGC53319, MGC75881, SLC25A8, Slc25a8, UCP2, ucp2, UCPH, uncoupling protein 2Protein level used designations for UCP2
- mitochondrial uncoupling protein 2
- uncoupling protein 2 (mitochondrial, proton carrier)
- Mitochondrial uncoupling protein 2
- uncoupling protein 2
- UCP 2
- solute carrier family 25 member 8
- zUCP2
- UCPH
- uncoupling protein 2, mitochondrial
- uncoupling protein homolog
- Uncoupling protein 2, mitochondrial
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