UBR5 Products
(Ubiquitin Protein Ligase E3 Component N-Recognin 5 (UBR5))
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This gene encodes a progestin-induced protein, which belongs to the HECT (homology to E6-AP carboxyl terminus) family. The HECT family proteins function as E3 ubiquitin-protein ligases, targeting specific proteins for ubiquitin-mediated proteolysis. This gene is localized to chromosome 8q22 which is disrupted in a variety of cancers. This gene potentially has a role in regulation of cell proliferation or differentiation. [provided by RefSeq, Jul 2008].
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Featured UBR5 Categories
UBR5 Antibodies
High quality antibodies with extensive validation data.
UBR5 ELISA Kits
Reliable ELISA kits for a wide range of species.
Recommended UBR5 Antibodies
Product
Reactivity
Application
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Human
Application
WB, IHC, ELISA
Validations
- (3)
Cat. No.
ABIN7183479
Quantity
100 μL
Datasheet
Datasheet
Reactivity
Human, Mouse
Application
WB, IHC, ELISA, IF, ICC
Validations
- (3)
Cat. No.
ABIN6261428
Quantity
100 μL
Datasheet
Datasheet
Reactivity
Human
Application
IHC, ELISA
Validations
- (2)
Cat. No.
ABIN184976
Quantity
100 μg
Datasheet
Datasheet
Recommended UBR5 ELISA Kits
Product
Reactivity
Analytical Method
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Human, Mouse
Analytical Method
Qualitative Cell ELISA
Validations
Cat. No.
ABIN1381095
Quantity
96 tests
Datasheet
Datasheet
Recommended UBR5 Proteins
Product
Reactivity
Source
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Human
Source
Wheat germ
Validations
- (1)
Cat. No.
ABIN1324480
Quantity
10 μg
Datasheet
Datasheet
Latest Publications for our UBR5 products
: "Activated Wnt/β-Catenin signaling contributes to E3 ubiquitin ligase EDD-conferred docetaxel resistance in prostate cancer." in: Life sciences, pp. 116816, (2019) (PubMed).: "Inhibition of caspases primes colon cancer cells for 5-fluorouracil-induced TNF-α-dependent necroptosis driven by RIP1 kinase and NF-κB." in: Oncogene, Vol. 35, Issue 26, pp. 3399-409, (2016) (PubMed).
: "Immunohistochemical analysis of Marinesco bodies, using antibodies against proteins implicated in the ubiquitin-proteasome system, autophagy and aggresome formation." in: Neuropathology : official journal of the Japanese Society of Neuropathology, Vol. 32, Issue 3, pp. 261-6, (2012) (PubMed).
: "A novel role for RIP1 kinase in mediating TNFα production." in: Cell death & disease, Vol. 3, pp. e320, (2012) (PubMed).
: "EDD inhibits ATM-mediated phosphorylation of p53." in: The Journal of biological chemistry, Vol. 286, Issue 17, pp. 14972-82, (2011) (PubMed).
: "Hepatic steatosis, inflammation, and ER stress in mice maintained long term on a very low-carbohydrate ketogenic diet." in: American journal of physiology. Gastrointestinal and liver physiology, Vol. 300, Issue 6, pp. G956-67, (2011) (PubMed).
: "A whole-genome RNAi screen identifies an 8q22 gene cluster that inhibits death receptor-mediated apoptosis." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 108, Issue 43, pp. E943-51, (2011) (PubMed).
: "Identification of cellular proteins that interact with the adeno-associated virus rep protein." in: Journal of virology, Vol. 83, Issue 1, pp. 454-69, (2008) (PubMed).
: "The E3 ubiquitin ligase EDD is an adverse prognostic factor for serous epithelial ovarian cancer and modulates cisplatin resistance in vitro." in: British journal of cancer, Vol. 98, Issue 6, pp. 1085-93, (2008) (PubMed).
: "EDD, the human orthologue of the hyperplastic discs tumour suppressor gene, is amplified and overexpressed in cancer." in: Oncogene, Vol. 22, Issue 32, pp. 5070-81, (2003) (PubMed).
Synonyms and alternative names related to UBR5
ubiquitin protein ligase E3 component n-recognin 5 (UBR5), ubiquitin protein ligase E3 component n-recognin 5 (Ubr5), 4432411E13Rik, AW549941, C77315, D030042K14, DD5, Dd5, EDD, Edd, EDD1, Edd1, HYD, mKIAA0896, Rat100Protein level used designations for UBR5
- E3 identified by differential display
- E3 ubiquitin protein ligase, HECT domain containing, 1
- E3 ubiquitin-protein ligase UBR5
- E3 ubiquitin-protein ligase, HECT domain-containing 1
- hHYD
- hyperplastic discs protein homolog
- progestin induced protein
- progestin-induced protein
- ubiquitin-protein ligase
- extraembryonic development
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