UBA3 Products
(Ubiquitin-Like Modifier Activating Enzyme 3 (UBA3))
Categories
The modification of proteins with ubiquitin is an important cellular mechanism for targeting abnormal or short-lived proteins for degradation. Ubiquitination involves at least three classes of enzymes: ubiquitin-activating enzymes, or E1s, ubiquitin-conjugating enzymes, or E2s, and ubiquitin-protein ligases, or E3s. This gene encodes a member of the E1 ubiquitin-activating enzyme family. The encoded enzyme associates with AppBp1, an amyloid beta precursor protein binding protein, to form a heterodimer, and then the enzyme complex activates NEDD8, a ubiquitin-like protein, which regulates cell division, signaling and embryogenesis. Multiple alternatively spliced transcript variants encoding distinct isoforms have been found for this gene. [provided by RefSeq, Jul 2008].
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Featured UBA3 Categories
UBA3 Antibodies
High quality antibodies with extensive validation data.
UBA3 ELISA Kits
Reliable ELISA kits for a wide range of species.
UBA3 Proteins
Proteins for various applications incl. WB, ELISA, IF etc.
Recommended UBA3 Antibodies
Product
Reactivity
Application
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Human, Mouse
Application
WB, IHC (p)
Validations
- (4)
Cat. No.
ABIN387909
Quantity
400 μL
Datasheet
Datasheet
Reactivity
Human, Mouse, Rat
Application
WB, IHC, ELISA
Validations
- (2)
Cat. No.
ABIN6265835
Quantity
100 μL
Datasheet
Datasheet
Reactivity
Human
Application
WB
Validations
- (2)
Cat. No.
ABIN7271186
Quantity
100 μL
Datasheet
Datasheet
Recommended UBA3 ELISA Kits
Product
Reactivity
Analytical Method
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Human
Analytical Method
Quantitative Sandwich ELISA
Validations
- (1)
Cat. No.
ABIN6971051
Quantity
96 tests
Datasheet
Datasheet
Reactivity
Mouse
Analytical Method
Validations
Cat. No.
ABIN1144447
Quantity
96 tests
Datasheet
Datasheet
Reactivity
Rat
Analytical Method
Validations
Cat. No.
ABIN1144448
Quantity
96 tests
Datasheet
Datasheet
Recommended UBA3 Proteins
Product
Reactivity
Source
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Human
Source
Wheat germ
Validations
- (1)
Cat. No.
ABIN1324294
Quantity
10 μg
Datasheet
Datasheet
Reactivity
Human
Source
Escherichia coli (E. coli)
Validations
- (1)
Cat. No.
ABIN7125641
Quantity
50 μg
Datasheet
Datasheet
Reactivity
Human
Source
Escherichia coli (E. coli)
Validations
Cat. No.
ABIN2132403
Quantity
100 μg
Datasheet
Datasheet
Latest Publications for our UBA3 products
: "The covalent modifier Nedd8 is critical for the activation of Smurf1 ubiquitin ligase in tumorigenesis." in: Nature communications, Vol. 5, pp. 3733, (2014) (PubMed).: "Immunofluorescence and fluorescent-protein tagging show high correlation for protein localization in mammalian cells." in: Nature methods, Vol. 10, Issue 4, pp. 315-23, (2013) (PubMed).
: "Insights into the ubiquitin transfer cascade from the structure of the activating enzyme for NEDD8." in: Nature, Vol. 422, Issue 6929, pp. 330-4, (2003) (PubMed).
: "Conservation in the mechanism of Nedd8 activation by the human AppBp1-Uba3 heterodimer." in: The Journal of biological chemistry, Vol. 278, Issue 29, pp. 26823-30, (2003) (PubMed).
Synonyms and alternative names related to UBA3
ubiquitin like modifier activating enzyme 3 (UBA3), ubiquitin-like modifier activating enzyme 3 (Uba3), ubiquitin-like modifier activating enzyme 3 (uba3), ubiquitin like modifier activating enzyme 3 (uba3), ubiquitin like modifier activating enzyme 3 S homeolog (uba3.S), A830034N06Rik, AI256736, AI848246, AW546539, hUBA3, UBE1C, Ube1c, ube1c, wu:fb75e04, wu:fc37b11, zgc:55528Protein level used designations for UBA3
- NEDD8-activating enzyme E1 catalytic subunit
- NEDD8-activating enzyme E1C
- Nedd8-activating enzyme hUba3
- UBA3, ubiquitin-activating enzyme E1 homolog
- ubiquitin-activating enzyme 3
- ubiquitin-activating enzyme E1C (UBA3 homolog, yeast)
- ubiquitin-activating enzyme E1C (homologous to yeast UBA3)
- ubiquitin-like modifier-activating enzyme 3
- ubiquitin activating enzyme 3
- ubiquitin-activating enzyme E1C
- ubiquitin-like modifier activating enzyme 3
- NEDD8-activating enzyme E1 catalytic subunit-like
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