TWEAK Products
(Tumor Necrosis Factor (Ligand) Superfamily, Member 12 (TNFSF12))
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The protein encoded by this gene is a cytokine that belongs to the tumor necrosis factor (TNF) ligand family. This protein is a ligand for the FN14/TWEAKR receptor. This cytokine has overlapping signaling functions with TNF, but displays a much wider tissue distribution. This cytokine, which exists in both membrane-bound and secreted forms, can induce apoptosis via multiple pathways of cell death in a cell type-specific manner. This cytokine is also found to promote proliferation and migration of endothelial cells, and thus acts as a regulator of angiogenesis. Alternative splicing results in multiple transcript variants. Some transcripts skip the last exon of this gene and continue into the second exon of the neighboring TNFSF13 gene\; such read-through transcripts are contained in GeneID 407977, TNFSF12-TNFSF13. [provided by RefSeq, Oct 2010].
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Featured TWEAK Categories
TWEAK Antibodies
High quality antibodies with extensive validation data.
TWEAK ELISA Kits
Reliable ELISA kits for a wide range of species.
TWEAK Proteins
Proteins for various applications incl. WB, ELISA, IF etc.
Recommended TWEAK Antibodies
Product
Reactivity
Application
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Human
Application
WB, IHC, IF
Validations
- (5)
Cat. No.
ABIN6149339
Quantity
100 μL
Datasheet
Datasheet
Reactivity
Human, Mouse, Rat
Application
WB, ELISA, IHC, IF, ICC
Validations
- (4)
Cat. No.
ABIN6265650
Quantity
100 μL
Datasheet
Datasheet
Reactivity
Human, Mouse, Rat
Application
IHC
Validations
- (3)
Cat. No.
ABIN7261608
Quantity
200 μL
Datasheet
Datasheet
Recommended TWEAK ELISA Kits
Product
Reactivity
Analytical Method
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Human
Analytical Method
Quantitative Sandwich ELISA
Validations
- (1)
- (1)
Cat. No.
ABIN6962633
Quantity
96 tests
Datasheet
Datasheet
Reactivity
Mouse
Analytical Method
Quantitative Sandwich ELISA
Validations
- (1)
Cat. No.
ABIN6970936
Quantity
96 tests
Datasheet
Datasheet
Reactivity
Human
Analytical Method
Quantitative Sandwich ELISA
Validations
- (1)
Cat. No.
ABIN6960250
Quantity
96 tests
Datasheet
Datasheet
Recommended TWEAK Proteins
Product
Reactivity
Source
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Human
Source
HEK-293 Cells
Validations
- (2)
Cat. No.
ABIN7275763
Quantity
100 μg
Datasheet
Datasheet
Reactivity
Human
Source
HEK-293T Cells
Validations
- (2)
Cat. No.
ABIN4369884
Quantity
2 μg
Datasheet
Datasheet
Reactivity
Human
Source
Wheat germ
Validations
- (1)
Cat. No.
ABIN1323218
Quantity
10 μg
Datasheet
Datasheet
Latest Publications for our TWEAK products
: "Serum tumor necrosis factor-like weak inducer of apoptosis levels are elevated in schizophrenia." in: Revista brasileira de psiquiatria (Sao Paulo, Brazil : 1999), (2020) (PubMed).: "The inflammatory cytokine TWEAK decreases PGC-1α expression and mitochondrial function in acute kidney injury." in: Kidney international, Vol. 89, Issue 2, pp. 399-410, (2016) (PubMed).
: "TWEAK protects cardiomyocyte against apoptosis in a PI3K/AKT pathway dependent manner." in: American journal of translational research, Vol. 8, Issue 9, pp. 3848-3860, (2016) (PubMed).
: "Increased serum tumor necrosis factor receptor-associated factor-6 expression in patients with non-metastatic triple-negative breast cancer." in: Oncology letters, Vol. 9, Issue 6, pp. 2819-2824, (2015) (PubMed).
: "Therapeutic targeting of TWEAK/Fnl4 in cancer: exploiting the intrinsic tumor cell killing capacity of the pathway." in: Results and problems in cell differentiation, Vol. 49, pp. 145-60, (2010) (PubMed).
: "Fibroblast growth factor-inducible 14 (Fn14) is expressed in the lower genital tract and may play a role in amplifying inflammation during infection." in: Journal of reproductive immunology, Vol. 84, Issue 1, pp. 16-23, (2010) (PubMed).
: "Expression profiles of novel cell surface molecules on B-cell subsets and plasma cells as analyzed by flow cytometry." in: Immunology letters, Vol. 134, Issue 2, pp. 113-21, (2010) (PubMed).
: "TWEAK/Fn14 interaction stimulates human bronchial epithelial cells to produce IL-8 and GM-CSF." in: Biochemical and biophysical research communications, Vol. 318, Issue 2, pp. 422-7, (2004) (PubMed).
: "The apoptotic ligands TRAIL, TWEAK, and Fas ligand mediate monocyte death induced by autologous lupus T cells." in: Journal of immunology (Baltimore, Md. : 1950), Vol. 169, Issue 10, pp. 6020-9, (2002) (PubMed).
: "Involvement of TWEAK in interferon gamma-stimulated monocyte cytotoxicity." in: The Journal of experimental medicine, Vol. 192, Issue 9, pp. 1373-80, (2000) (PubMed).
Synonyms and alternative names related to TWEAK
TNF superfamily member 12 (TNFSF12), tumor necrosis factor (ligand) superfamily, member 12 (TNFSF12), tumor necrosis factor (ligand) superfamily, member 12 (Tnfsf12), TNF superfamily member 12 (Tnfsf12), APO3L, Apo3l, Dr3l, DR3LG, Dr3lg, TWEAK, TweakProtein level used designations for TWEAK
- APO3 ligand
- APO3/DR3 ligand
- TNF-related WEAK inducer of apoptosis
- tumor necrosis factor ligand superfamily member 12
- tumor necrosis factor superfamily member 12
- TNF-related weak inducer of apoptosis
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