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TSPO Products

(Peripheral-Type Benzodiazepine Receptor (TSPO))

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Present mainly in the mitochondrial compartment of peripheral tissues, the protein encoded by this gene interacts with some benzodiazepines and has different affinities than its endogenous counterpart. The protein is a key factor in the flow of cholesterol into mitochondria to permit the initiation of steroid hormone synthesis. Alternatively spliced transcript variants have been reported\; one of the variants lacks an internal exon and is considered non-coding, and the other variants encode the same protein. [provided by RefSeq, Feb 2012].

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Featured TSPO Categories

TSPO Antibodies

High quality antibodies with extensive validation data.

TSPO ELISA Kits

Reliable ELISA kits for a wide range of species.

TSPO Proteins

Proteins for various applications incl. WB, ELISA, IF etc.

Recommended TSPO Antibodies

Product
Reactivity
Application
Validations
Cat. No.
Quantity
Datasheet
Reactivity Mouse
Application WB, ELISA, IHC, FACS
Validations
  • (1)
  • (11)
Cat. No. ABIN570960
Quantity 100 μg
Datasheet Datasheet
Reactivity Human
Application WB, ELISA, IHC, IP, IF, FACS
Validations
  • (6)
Cat. No. ABIN7127858
Quantity 100 μL
Datasheet Datasheet
Reactivity Human
Application WB, ELISA, IHC, IF, FACS
Validations
  • (8)
Cat. No. ABIN185697
Quantity 100 μg
Datasheet Datasheet

Recommended TSPO ELISA Kits

Product
Reactivity
Analytical Method
Validations
Cat. No.
Quantity
Datasheet
Reactivity Mouse
Analytical Method Quantitative Sandwich ELISA
Validations
  • (1)
Cat. No. ABIN6969216
Quantity 96 tests
Datasheet Datasheet
Reactivity Human
Analytical Method Quantitative Sandwich ELISA
Validations
  • (1)
Cat. No. ABIN6958481
Quantity 96 tests
Datasheet Datasheet
Reactivity Human
Analytical Method Quantitative Sandwich ELISA
Validations
  • (1)
Cat. No. ABIN1572930
Quantity 96 tests
Datasheet Datasheet

Recommended TSPO Proteins

Product
Reactivity
Source
Validations
Cat. No.
Quantity
Datasheet
Reactivity Human
Source Wheat germ
Validations
  • (1)
Cat. No. ABIN1323951
Quantity 10 μg
Datasheet Datasheet
Reactivity Human
Source Escherichia coli (E. coli)
Validations
Cat. No. ABIN7399829
Quantity 100 μg
Datasheet Datasheet
Reactivity Human
Source Tobacco (Nicotiana tabacum)
Validations
Cat. No. ABIN3074824
Quantity 1 mg
Datasheet Datasheet

Latest Publications for our TSPO products

Hieu Tran, Park, Park, Kwon, Kang, Ho Jung, Chang, Chul Lee, Lee, Kang, Kim: "Synthesis and evaluation of novel potent TSPO PET ligands with 2-phenylpyrazolo[1,5-a]pyrimidin-3-yl acetamide." in: Bioorganic & medicinal chemistry, Vol. 27, Issue 18, pp. 4069-4080, (2019) (PubMed).

Foss, Liu, Mease, Wang, Pasricha, Pomper: "Imaging Macrophage Accumulation in a Murine Model of Chronic Pancreatitis with (125)I-Iodo-DPA-713 SPECT/CT." in: Journal of nuclear medicine : official publication, Society of Nuclear Medicine, Vol. 58, Issue 10, pp. 1685-1690, (2017) (PubMed).

Zhou, Frabutt, Moremen, Zheng: "ERManI (Endoplasmic Reticulum Class I α-Mannosidase) Is Required for HIV-1 Envelope Glycoprotein Degradation via Endoplasmic Reticulum-associated Protein Degradation Pathway." in: The Journal of biological chemistry, Vol. 290, Issue 36, pp. 22184-92, (2015) (PubMed).

Buck, McKinley, Fu, Abel, Thompson, Chambless, Watchmaker, Harty, Cooper, Manning: "Preclinical TSPO Ligand PET to Visualize Human Glioma Xenotransplants: A Preliminary Study." in: PLoS ONE, Vol. 10, Issue 10, pp. e0141659, (2015) (PubMed).

Zhou, Dang, Zheng: "The mitochondrial translocator protein, TSPO, inhibits HIV-1 envelope glycoprotein biosynthesis via the endoplasmic reticulum-associated protein degradation pathway." in: Journal of virology, Vol. 88, Issue 6, pp. 3474-84, (2014) (PubMed).

Bae, Shim, Balu, Kim, Yu: "Translocator protein 18 kDa negatively regulates inflammation in microglia." in: Journal of neuroimmune pharmacology : the official journal of the Society on NeuroImmune Pharmacology, Vol. 9, Issue 3, pp. 424-37, (2014) (PubMed).

Taylor, Allen, Graham: "Targeting mitochondrial 18 kDa translocator protein (TSPO) regulates macrophage cholesterol efflux and lipid phenotype." in: Clinical science (London, England : 1979), Vol. 127, Issue 10, pp. 603-13, (2014) (PubMed).

Wu, Gallo: "The 18-kDa translocator protein (TSPO) disrupts mammary epithelial morphogenesis and promotes breast cancer cell migration." in: PLoS ONE, Vol. 8, Issue 8, pp. e71258, (2013) (PubMed).

Morgan, Cheepala, Wang, Neale, Adachi, Nachagari, Leggas, Zhao, Boyd, Venkataramanan, Schuetz: "Deregulated hepatic metabolism exacerbates impaired testosterone production in Mrp4-deficient mice." in: The Journal of biological chemistry, Vol. 287, Issue 18, pp. 14456-66, (2012) (PubMed).

Joo, Lee, Lim, Lee, Choi, Cho, Park, Ryoo, Park, Jeon: "Peripheral benzodiazepine receptor regulates vascular endothelial activations via suppression of the voltage-dependent anion channel-1." in: FEBS letters, Vol. 586, Issue 9, pp. 1349-55, (2012) (PubMed).

Synonyms and alternative names related to TSPO

peripheral-type benzodiazepine receptor (LOC732875), peripheral-type benzodiazepine receptor (MAV_3896), Peripheral-type benzodiazepine receptor (xccb100_2086), putative peripheral-type benzodiazepine receptor (Smp_102510), peripheral-type benzodiazepine receptor (Sros_1911), translocator protein (tspo), translocator protein homolog (LOC100280949), hypothetical protein (PGTG_16395), translocator protein (TSPO), translocator protein (Tspo), BPBS, BZRP, Bzrp, DBI, IBP, LOC732875, LOC100136652, LOC100280949, MBR, mDRC, PBR, PBS, pk18, PKBS, PTBR, Ptbzr, PTBZR02, RATPTBZR02, TSPO, Tspo1

Protein level used designations for TSPO

  • peripheral-type benzodiazepine receptor
  • Peripheral-type benzodiazepine receptor
  • translocator protein
  • PKBS
  • benzodiazepine receptor, peripheral
  • isoquinoline-binding protein
  • mitochondrial benzodiazepine receptor
  • Benzodiazepin receptor (peripheral)
  • PBR
  • benzodiazepine peripheral binding site
  • peripheral benzodiazepine receptor
  • IBP
  • benzodiazepine receptor (peripheral)
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