Tropomyosin 1 (Alpha) Products
(Tropomyosin 1 (Alpha) (TPM1))
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This gene is a member of the tropomyosin family of highly conserved, widely distributed actin-binding proteins involved in the contractile system of striated and smooth muscles and the cytoskeleton of non-muscle cells. Tropomyosin is composed of two alpha-helical chains arranged as a coiled-coil. It is polymerized end to end along the two grooves of actin filaments and provides stability to the filaments. The encoded protein is one type of alpha helical chain that forms the predominant tropomyosin of striated muscle, where it also functions in association with the troponin complex to regulate the calcium-dependent interaction of actin and myosin during muscle contraction. In smooth muscle and non-muscle cells, alternatively spliced transcript variants encoding a range of isoforms have been described. Mutations in this gene are associated with type 3 familial hypertrophic cardiomyopathy. [provided by RefSeq, Jul 2008].
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Tropomyosin 1 (Alpha) Antibodies
High quality antibodies with extensive validation data.
Tropomyosin 1 (Alpha) Proteins
Proteins for various applications incl. WB, ELISA, IF etc.
Recommended Tropomyosin 1 (Alpha) Antibodies
Product
Reactivity
Application
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Human
Application
WB, IHC, IF
Validations
- (1)
- (5)
Cat. No.
ABIN3021578
Quantity
100 μL
Datasheet
Datasheet
Reactivity
Human
Application
WB, IHC, IF, IP
Validations
- (6)
Cat. No.
ABIN7271013
Quantity
100 μL
Datasheet
Datasheet
Reactivity
Mouse, Rat
Application
WB, IHC, IF
Validations
- (5)
Cat. No.
ABIN7076030
Quantity
100 μL
Datasheet
Datasheet
Recommended Tropomyosin 1 (Alpha) Proteins
Product
Reactivity
Source
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Human
Source
Wheat germ
Validations
- (1)
Cat. No.
ABIN1323433
Quantity
10 μg
Datasheet
Datasheet
Reactivity
Human
Source
Wheat germ
Validations
- (1)
Cat. No.
ABIN1323431
Quantity
10 μg
Datasheet
Datasheet
Reactivity
Human
Source
Escherichia coli (E. coli)
Validations
Cat. No.
ABIN7504554
Quantity
100 μg
Datasheet
Datasheet
Latest Publications for our Tropomyosin 1 (Alpha) products
: "Disruption of cardiac thin filament assembly arising from a mutation in LMOD2: A novel mechanism of neonatal dilated cardiomyopathy." in: Science advances, Vol. 5, Issue 9, pp. eaax2066, (2019) (PubMed).: "Quantitative Proteomics Analysis Reveals Novel Targets of miR-21 in Zebrafish Embryos." in: Scientific reports, Vol. 7, Issue 1, pp. 4022, (2018) (PubMed).
: "Tropomyosin-1 protects transformed alveolar epithelial cells against cigaret smoke extract through the stabilization of F-actin-dependent cell-cell junctions." in: Acta histochemica, Vol. 118, Issue 3, pp. 225-35, (2016) (PubMed).
: "From the Cover: Neutralization of terminal differentiation in gliomagenesis." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 110, Issue 36, pp. 14520-7, (2013) (PubMed).
: "Osteopontin regulates α-smooth muscle actin and calponin in vascular smooth muscle cells." in: Cell biology international, Vol. 36, Issue 2, pp. 155-61, (2012) (PubMed).
: "Role of the head-to-tail overlap region in smooth and skeletal muscle beta-tropomyosin." in: Biochemistry, Vol. 47, Issue 1, pp. 388-97, (2008) (PubMed).
: "Tropomyosin-based regulation of the actin cytoskeleton in time and space." in: Physiological reviews, Vol. 88, Issue 1, pp. 1-35, (2008) (PubMed).
: "Tropomyosin's periods are quasi-equivalent for actin binding but have specific regulatory functions." in: Biochemistry, Vol. 46, Issue 51, pp. 14917-27, (2007) (PubMed).
: "From gene expression analysis to tissue microarrays: a rational approach to identify therapeutic and diagnostic targets in lymphoid malignancies." in: Molecular & cellular proteomics : MCP, Vol. 5, Issue 6, pp. 1072-81, (2006) (PubMed).
Synonyms and alternative names related to Tropomyosin 1 (Alpha)
tropomyosin 1 (alpha) (TPM1), tropomyosin (tm7), tropomyosin 1 (TPM1), tropomyosin 1, alpha (Tpm1), tropomyosin 1 (Tpm1), alpha-tropomyosin (tpma), tropomyosin 1 L homeolog (tpm1.L), tropomyosin (Smp_044010.2), tropomyosin 1 (LOC732984), tropomyosin 1 (alpha) (tpm1), AA986836, AI854628, alpha-fTM, alpha-TM, Alpha-tm, alpha-tm, alpha-tropomyosin, C15orf13, CH1, CMD1Y, CMH3, fb37a09, HTM-alpha, MGC84844, tm, Tm1, TM2, Tm3, Tm7, Tma2, Tmpa, Tmsa, TMSA, Tpm-1, tpm1, TPM1, TPMA, wu:fb37a09, zgc:55951, zgc:77009, zgc:171719Protein level used designations for Tropomyosin 1 (Alpha)
- alpha-tropomyosin 1
- alpha-tropomyosin 2
- alpha-tropomyosin of skeletal fast muscle
- tropomyosin (CTm4)
- tropomyosin (CTm7)
- tropomyosin alpha-1 chain
- tropomyosin-1
- tropomyosin
- Tropomyosin-1 alpha chain
- tropomyosin 1 alpha chain
- alpha tropomyosin
- alpha-tropomyosin
- hepatoma alpha tropomyosin
- smooth muscle alpha-tropomyosin
- striated muscle alpha-tropomyosin
- tropomyosin 3 alpha
- alpha-skeletal tropomyosin
- cardiomyopathy, hypertrophic 3
- sarcomeric tropomyosin kappa
- tropomyosin 1 (alpha) isoform 1
- tropomyosin 1 (alpha) isoform 2
- tropomyosin 1 (alpha) isoform 3
- tropomyosin 1 (alpha) isoform 4
- tropomyosin 1 (alpha) isoform 5
- tropomyosin 1 (alpha) isoform 6
- tropomyosin 1 (alpha) isoform 7
- tropomyosin 1-1
- tropomyosin 1 (alpha)
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