TRIM5 Products
(Tripartite Motif Containing 5 (TRIM5))
Categories
The protein encoded by this gene is a member of the tripartite motif (TRIM) family. The TRIM motif includes three zinc-binding domains, a RING, a B-box type 1 and a B-box type 2, and a coiled-coil region. The protein forms homo-oligomers via the coilel-coil region and localizes to cytoplasmic bodies. It appears to function as a E3 ubiquitin-ligase and ubiqutinates itself to regulate its subcellular localization. It may play a role in retroviral restriction. Multiple alternatively spliced transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Dec 2009].
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Featured TRIM5 Categories
TRIM5 Antibodies
High quality antibodies with extensive validation data.
TRIM5 Proteins
Proteins for various applications incl. WB, ELISA, IF etc.
Recommended TRIM5 Antibodies
Product
Reactivity
Application
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Human
Application
WB, ELISA, IHC
Validations
- (7)
Cat. No.
ABIN184983
Quantity
100 μg
Datasheet
Datasheet
Reactivity
Human
Application
WB
Validations
- (6)
Cat. No.
ABIN2778419
Quantity
100 μL
Datasheet
Datasheet
Reactivity
Human
Application
WB, ELISA, IHC
Validations
- (3)
- (3)
Cat. No.
ABIN969443
Quantity
100 μL
Datasheet
Datasheet
Recommended TRIM5 ELISA Kits
Product
Reactivity
Analytical Method
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Human
Analytical Method
Quantitative Sandwich ELISA
Validations
Cat. No.
ABIN6211786
Quantity
96 tests
Datasheet
Datasheet
Recommended TRIM5 Proteins
Product
Reactivity
Source
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Human
Source
Wheat germ
Validations
- (1)
Cat. No.
ABIN1323702
Quantity
10 μg
Datasheet
Datasheet
Reactivity
Human
Source
Wheat germ
Validations
- (1)
Cat. No.
ABIN1323704
Quantity
10 μg
Datasheet
Datasheet
Reactivity
Human
Source
Escherichia coli (E. coli)
Validations
Cat. No.
ABIN1945366
Quantity
50 μg
Datasheet
Datasheet
Latest Publications for our TRIM5 products
: "Stabilized human TRIM5α protects human T cells from HIV-1 infection." in: Molecular therapy : the journal of the American Society of Gene Therapy, Vol. 22, Issue 6, pp. 1084-95, (2014) (PubMed).: "Type I interferon responses in rhesus macaques prevent SIV infection and slow disease progression. ..." in: Nature, Vol. 511, Issue 7511, pp. 601-5, (2014) (PubMed).
: "Determinants of the higher order association of the restriction factor TRIM5alpha and other tripartite motif (TRIM) proteins." in: The Journal of biological chemistry, Vol. 286, Issue 32, pp. 27959-70, (2011) (PubMed).
: "Restriction of foamy viruses by primate Trim5alpha." in: Journal of virology, Vol. 82, Issue 11, pp. 5429-39, (2008) (PubMed).
: "The design of artificial retroviral restriction factors." in: Virology, Vol. 365, Issue 2, pp. 302-14, (2007) (PubMed).
: "All three variable regions of the TRIM5alpha B30.2 domain can contribute to the specificity of retrovirus restriction." in: Journal of virology, Vol. 80, Issue 17, pp. 8554-65, (2006) (PubMed).
: "Retrovirus restriction by TRIM5alpha variants from Old World and New World primates." in: Journal of virology, Vol. 79, Issue 7, pp. 3930-7, (2005) (PubMed).
: "Cyclophilin A is required for TRIM5{alpha}-mediated resistance to HIV-1 in Old World monkey cells." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 102, Issue 41, pp. 14849-53, (2005) (PubMed).
: "The human and African green monkey TRIM5alpha genes encode Ref1 and Lv1 retroviral restriction factor activities." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 101, Issue 29, pp. 10780-5, (2004) (PubMed).
: "The cytoplasmic body component TRIM5alpha restricts HIV-1 infection in Old World monkeys." in: Nature, Vol. 427, Issue 6977, pp. 848-53, (2004) (PubMed).
Synonyms and alternative names related to TRIM5
tripartite motif containing 5 (TRIM5), tripartite motif-containing 5 (Trim5), EG667823, Gm8833, RGD1304579, RNF88, TRIM5, TRIM5alphaProtein level used designations for TRIM5
- tripartite motif-containing 5
- TRIM5alpha
- tripartite motif-containing 5 alpha
- tripartite motif-containing protein 5
- tri-partite motif protein 5
- ring finger protein 88
- tripartite motif containing 5 transcript variant iota
- tripartite motif containing 5 transcript variant kappa
- tripartite motif protein TRIM5
- tripartite motif-containing protein 5 isoform alpha
- TRIM5 alpha
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