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TRIB3 Products

(Tribbles Homolog 3 (Drosophila) (TRIB3))

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The protein encoded by this gene is a putative protein kinase that is induced by the transcription factor NF-kappaB. The encoded protein is a negative regulator of NF-kappaB and can also sensitize cells to TNF- and TRAIL-induced apoptosis. In addition, this protein can negatively regulate the cell survival serine-threonine kinase AKT1. [provided by RefSeq, Jul 2008].

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Featured TRIB3 Categories

TRIB3 Antibodies

High quality antibodies with extensive validation data.

TRIB3 ELISA Kits

Reliable ELISA kits for a wide range of species.

TRIB3 Proteins

Proteins for various applications incl. WB, ELISA, IF etc.

Recommended TRIB3 Antibodies

Product
Reactivity
Application
Validations
Cat. No.
Quantity
Datasheet
Reactivity Human
Application WB, ELISA, IF, RNAi
Validations
  • (4)
Cat. No. ABIN566162
Quantity 100 μg
Datasheet Datasheet
Reactivity Human
Application WB, ELISA, IP
Validations
  • (4)
Cat. No. ABIN566165
Quantity 100 μg
Datasheet Datasheet
Reactivity Human
Application WB, IHC (p)
Validations
  • (3)
Cat. No. ABIN392789
Quantity 400 μL
Datasheet Datasheet

Recommended TRIB3 ELISA Kits

Product
Reactivity
Analytical Method
Validations
Cat. No.
Quantity
Datasheet
Reactivity Human
Analytical Method Quantitative Sandwich ELISA
Validations
  • (1)
Cat. No. ABIN6970847
Quantity 96 tests
Datasheet Datasheet
Reactivity Rat
Analytical Method Quantitative Sandwich ELISA
Validations
Cat. No. ABIN6209171
Quantity 96 tests
Datasheet Datasheet
Reactivity Mouse
Analytical Method
Validations
Cat. No. ABIN1163742
Quantity 96 tests
Datasheet Datasheet

Recommended TRIB3 Proteins

Product
Reactivity
Source
Validations
Cat. No.
Quantity
Datasheet
Reactivity Human
Source Wheat germ
Validations
  • (1)
Cat. No. ABIN1323595
Quantity 10 μg
Datasheet Datasheet
Reactivity Human
Source Wheat germ
Validations
  • (1)
Cat. No. ABIN1323593
Quantity 10 μg
Datasheet Datasheet
Reactivity Human
Source Baculovirus infected Insect Cells
Validations
  • (1)
Cat. No. ABIN7198334
Quantity 50 μg
Datasheet Datasheet

Latest Publications for our TRIB3 products

Nourbakhsh, Sharifi, Ghorbanhosseini, Javad, Ahmadpour, Razzaghy Azar, Larijani: "Evaluation of Plasma TRB3 and Sestrin 2 Levels in Obese and Normal-Weight Children." in: Childhood obesity (Print), Vol. 13, Issue 5, pp. 409-414, (2018) (PubMed).

Izrailit, Jaiswal, Zheng, Moran, Reedijk: "Cellular stress induces TRB3/USP9x-dependent Notch activation in cancer." in: Oncogene, (2016) (PubMed).

Guo, Guo, Gong, Shang, Zhong, Zhang, Zhang: "Tribbles homolog 3 is induced by high glucose and associated with apoptosis in human endothelial cells." in: Molecular medicine reports, Vol. 12, Issue 2, pp. 1963-70, (2015) (PubMed).

Izrailit, Berman, Datti, Wrana, Reedijk: "High throughput kinase inhibitor screens reveal TRB3 and MAPK-ERK/TGFβ pathways as fundamental Notch regulators in breast cancer." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 110, Issue 5, pp. 1714-9, (2013) (PubMed).

Wang, Shang, Zhang, Zhong, Wang, Deng, Pan, Zhang, Zhang: "Silence of TRIB3 suppresses atherosclerosis and stabilizes plaques in diabetic ApoE-/-/LDL receptor-/- mice." in: Diabetes, Vol. 61, Issue 2, pp. 463-73, (2012) (PubMed).

Wennemers, Bussink, Scheijen, Nagtegaal, van Laarhoven, Raleigh, Varia, Heuvel, Rouschop, Sweep, Span: "Tribbles homolog 3 denotes a poor prognosis in breast cancer and is involved in hypoxia response." in: Breast cancer research : BCR, Vol. 13, Issue 4, pp. R82, (2011) (PubMed).

Chan, Hilyard, Wu, Davis, Hill, Lal, Lieberman, Lagna, Hata: "Molecular basis for antagonism between PDGF and the TGFbeta family of signalling pathways by control of miR-24 expression." in: The EMBO journal, Vol. 29, Issue 3, pp. 559-73, (2010) (PubMed).

Loewen, Chen, Dudley, Sarthy, Mathura: "Genomic response of hypoxic Müller cells involves the very low density lipoprotein receptor as part of an angiogenic network." in: Experimental eye research, Vol. 88, Issue 5, pp. 928-37, (2009) (PubMed).

Miyoshi, Ishii, Mimori, Takatsuno, Kim, Hirose, Sekimoto, Doki, Mori: "Abnormal expression of TRIB3 in colorectal cancer: a novel marker for prognosis." in: British journal of cancer, Vol. 101, Issue 10, pp. 1664-70, (2009) (PubMed).

Wu, Xu, Zhai, Shu: "SINK is a p65-interacting negative regulator of NF-kappaB-dependent transcription." in: The Journal of biological chemistry, Vol. 278, Issue 29, pp. 27072-9, (2003) (PubMed).

Synonyms and alternative names related to TRIB3

tribbles pseudokinase 3 (trib3), tribbles pseudokinase 3 (TRIB3), tribbles pseudokinase 3 (Trib3), C20orf97, Ifld2, NIPK, Nipk, SINK, SKIP3, TRB-3, TRB3, Trb3, TRIB3, zgc:76966

Protein level used designations for TRIB3

  • tribbles homolog 3
  • tribbles homolog 3 (Drosophila)
  • tribbles homolog 3-like
  • TRB-3
  • neuronal cell death inducible putative kinase
  • neuronal cell death-inducible putative kinase
  • p65-interacting inhibitor of NF-kappa-B
  • p65-interacting inhibitor of NF-kappaB
  • induced in fatty liver dystrophy 2
  • Neuronal cell death Inducible Putative Kinase
  • kinase
  • tribbles 3
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