TRIB2 Products
(Tribbles Pseudokinase 2 (TRIB2))
Categories
This gene encodes one of three members of the Tribbles family. The Tribbles members share a Trb domain, which is homologous to protein serine-threonine kinases, but lacks the active site lysine and probably lacks a catalytic function. The Tribbles proteins interact and modulate the activity of signal transduction pathways in a number of physiological and pathological processes. This Tribbles member induces apoptosis of cells mainly of the hematopoietic origin. It has been identified as a protein up-regulated by inflammatory stimuli in myeloid (THP-1) cells, and also as an oncogene that inactivates the transcription factor C/EBPalpha (CCAAT/enhancer-binding protein alpha) and causes acute myelogenous leukemia. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Mar 2009].
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Featured TRIB2 Categories
TRIB2 Antibodies
High quality antibodies with extensive validation data.
TRIB2 Proteins
Proteins for various applications incl. WB, ELISA, IF etc.
Recommended TRIB2 Antibodies
Product
Reactivity
Application
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Human
Application
WB, ELISA, IHC (p), RNAi
Validations
- (3)
- (6)
Cat. No.
ABIN565396
Quantity
100 μg
Datasheet
Datasheet
Reactivity
Human
Application
WB, ELISA, IF (cc), IF (p), IHC (p), IHC (fro)
Validations
- (3)
Cat. No.
ABIN716546
Quantity
100 μL
Datasheet
Datasheet
Reactivity
Human
Application
WB, IHC (p), FACS
Validations
- (3)
Cat. No.
ABIN652876
Quantity
400 μL
Datasheet
Datasheet
Recommended TRIB2 ELISA Kits
Product
Reactivity
Analytical Method
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Human
Analytical Method
Quantitative Sandwich ELISA
Validations
Cat. No.
ABIN6209170
Quantity
96 tests
Datasheet
Datasheet
Recommended TRIB2 Proteins
Product
Reactivity
Source
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Human
Source
Wheat germ
Validations
- (1)
- (1)
Cat. No.
ABIN1323589
Quantity
10 μg
Datasheet
Datasheet
Reactivity
Human
Source
Wheat germ
Validations
- (1)
Cat. No.
ABIN1323591
Quantity
10 μg
Datasheet
Datasheet
Reactivity
Human
Source
Baculovirus infected Insect Cells
Validations
- (1)
Cat. No.
ABIN7198335
Quantity
50 μg
Datasheet
Datasheet
Latest Publications for our TRIB2 products
: "TRIB2 inhibits Wnt/?-Catenin/TCF4 signaling through its associated ubiquitin E3 ligases, ?-TrCP, COP1 and Smurf1, in liver cancer cells." in: FEBS letters, Vol. 588, Issue 23, pp. 4334-41, (2014) (PubMed).: "Enhanced macrophage tribbles-1 expression in murine experimental atherosclerosis." in: Biology, Vol. 1, Issue 1, pp. 43-57, (2014) (PubMed).
: "Impaired phosphorylation and ubiquitination by p70 S6 kinase (p70S6K) and Smad ubiquitination regulatory factor 1 (Smurf1) promote tribbles homolog 2 (TRIB2) stability and carcinogenic property in ..." in: The Journal of biological chemistry, Vol. 288, Issue 47, pp. 33667-81, (2013) (PubMed).
: "Ubiquitin E3 ligase SCF(?-TRCP) regulates TRIB2 stability in liver cancer cells." in: Biochemical and biophysical research communications, Vol. 441, Issue 3, pp. 555-9, (2013) (PubMed).
Synonyms and alternative names related to TRIB2
tribbles pseudokinase 2 (TRIB2), tribbles pseudokinase 2 (trib2), tribbles pseudokinase 2 S homeolog (trib2.S), tribbles pseudokinase 2 (Trib2), AW319517, c5fw, C5FW, gs3955, GS3955, RGD1564451, TRB-2, Trb2, trb2, TRB2, TRIB2, xtrb2, XtrblProtein level used designations for TRIB2
- tribbles homolog 2 (Drosophila)
- tribbles homolog 2-like
- tribbles homolog 2
- serine/threonine protein kinase
- tribbles-like protein 2
- TRB-2
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