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TRAF6 Products

(TNF Receptor-Associated Factor 6 (TRAF6))

Categories

The protein encoded by this gene is a member of the TNF receptor associated factor (TRAF) protein family. TRAF proteins are associated with, and mediate signal transduction from, members of the TNF receptor superfamily. This protein mediates signaling from members of the TNF receptor superfamily as well as the Toll/IL-1 family. Signals from receptors such as CD40, TNFSF11/RANCE and IL-1 have been shown to be mediated by this protein. This protein also interacts with various protein kinases including IRAK1/IRAK, SRC and PKCzeta, which provides a link between distinct signaling pathways. This protein functions as a signal transducer in the NF-kappaB pathway that activates IkappaB kinase (IKK) in response to proinflammatory cytokines. The interaction of this protein with UBE2N/UBC13, and UBE2V1/UEV1A, which are ubiquitin conjugating enzymes catalyzing the formation of polyubiquitin chains, has been found to be required for IKK activation by this protein. This protein also interacts with the transforming growth factor (TGF) beta receptor complex and is required for Smad-independent activation of the JNK and p38 kinases. This protein has an amino terminal RING domain which is followed by four zinc-finger motifs, a central coiled-coil region and a highly conserved carboxyl terminal domain, known as the TRAF-C domain. Two alternatively spliced transcript variants, encoding an identical protein, have been reported. [provided by RefSeq, Feb 2012].

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Featured TRAF6 Categories

TRAF6 Antibodies

High quality antibodies with extensive validation data.

TRAF6 ELISA Kits

Reliable ELISA kits for a wide range of species.

TRAF6 Proteins

Proteins for various applications incl. WB, ELISA, IF etc.

Recommended TRAF6 Antibodies

Product
Reactivity
Application
Validations
Cat. No.
Quantity
Datasheet
Reactivity Human
Application WB, IHC, IP, ICC
Validations
  • (7)
Cat. No. ABIN7436348
Quantity 100 μL
Datasheet Datasheet
Reactivity Human
Application WB, ELISA, RNAi, PLA
Validations
  • (5)
Cat. No. ABIN521096
Quantity 50 μg
Datasheet Datasheet
Reactivity Human
Application ELISA, IHC, IF
Validations
  • (3)
Cat. No. ABIN7172247
Quantity 100 μg
Datasheet Datasheet

Recommended TRAF6 ELISA Kits

Product
Reactivity
Analytical Method
Validations
Cat. No.
Quantity
Datasheet
Reactivity Human
Analytical Method Quantitative Sandwich ELISA
Validations
  • (1)
  • (1)
Cat. No. ABIN6960020
Quantity 96 tests
Datasheet Datasheet
Reactivity Human
Analytical Method Quantitative Sandwich ELISA
Validations
  • (1)
Cat. No. ABIN6970729
Quantity 96 tests
Datasheet Datasheet
Reactivity Human
Analytical Method Quantitative Competition ELISA
Validations
Cat. No. ABIN510579
Quantity 96 tests
Datasheet Datasheet

Recommended TRAF6 Proteins

Product
Reactivity
Source
Validations
Cat. No.
Quantity
Datasheet
Reactivity Human
Source Wheat germ
Validations
  • (1)
  • (1)
Cat. No. ABIN1323514
Quantity 10 μg
Datasheet Datasheet
Reactivity Human
Source Wheat germ
Validations
  • (1)
Cat. No. ABIN1323516
Quantity 10 μg
Datasheet Datasheet
Reactivity Human
Source HEK-293 Cells
Validations
  • (1)
  • (1)
Cat. No. ABIN2734115
Quantity 20 μg
Datasheet Datasheet

Latest Publications for our TRAF6 products

Wang, Liu, Wu, Wei, Sheng, You, Shang, Kuang: "Moderate prenatal alcohol exposure suppresses the TLR4-mediated innate immune response in the hippocampus of young rats." in: Neuroscience letters, Vol. 699, pp. 77-83, (2019) (PubMed).

Abdel Motaleb, Nabih, Mohamed, Abd Elhalim: "Up-regulation of circulating miRNA146a correlates with viral load via IRAK1 and TRAF6 in hepatitis C virus-infected patients." in: Virus research, Vol. 238, pp. 24-28, (2018) (PubMed).

Zhang, Fei, Tao, Li, Shen, Wang, Liu, Xu: "Neuroprotective Effect of Modified Xijiao Dihuang Decoction against Oxygen-Glucose Deprivation and Reoxygenation-Induced Injury in PC12 Cells: Involvement of TLR4-MyD88/NF-κB Signaling Pathway." in: Evidence-based complementary and alternative medicine : eCAM, Vol. 2017, pp. 3848595, (2018) (PubMed).

Teng, Luo, Yu, Chen, Huang, Chen, Xie, Zeng, Luo, Xiong, Liu, Hou, Feng: "CRISPR/Cas9-mediated deletion of miR-146a enhances antiviral response in HIV-1 infected cells." in: Genes and immunity, (2018) (PubMed).

Wei, Wan, Peng, Zhou, Lu, He: "Antiviral effects of Ma Huang Tang against H1N1 influenza virus infection in vitro and in an ICR pneumonia mouse model." in: Biomedicine & pharmacotherapy, Vol. 102, pp. 1161-1175, (2018) (PubMed).

Qi, Pradipta, Li, Zhao, Lu, Fu, Wei, Hsung, Tanaka, Zhou: "Cinchonine induces apoptosis of HeLa and A549 cells through targeting TRAF6." in: Journal of experimental & clinical cancer research : CR, Vol. 36, Issue 1, pp. 35, (2017) (PubMed).

Li, Yu, Li, Liu, Jiao, Song, Lv, Qin: "Phycocyanin attenuates pulmonary fibrosis via the TLR2-MyD88-NF-κB signaling pathway." in: Scientific reports, Vol. 7, Issue 1, pp. 5843, (2017) (PubMed).

Ye, Yang, Chen, Li, Jia, Su, Wang, He: "Electroacupuncture Improved Hippocampal Neurogenesis following Traumatic Brain Injury in Mice through Inhibition of TLR4 Signaling Pathway." in: Stem cells international, Vol. 2017, pp. 5841814, (2017) (PubMed).

He, Qiu, Dai, Fang, Sun, Gong, Ding, Sun: "MicroRNA-351 inhibits denervation-induced muscle atrophy by targeting TRAF6." in: Experimental and therapeutic medicine, Vol. 12, Issue 6, pp. 4029-4034, (2016) (PubMed).

Bilir, Engin, Can, Temi, Demirtas: "The prognostic role of inflammation and hormones in patients with metastatic cancer with cachexia." in: Medical oncology (Northwood, London, England), Vol. 32, Issue 3, pp. 56, (2015) (PubMed).

Synonyms and alternative names related to TRAF6

TNF receptor associated factor 6 (TRAF6), TNF receptor-associated factor 6 (Traf6), TNF receptor associated factor 6 L homeolog (traf6.L), TNF-receptor-associated factor 6 (Traf6), TNF receptor associated factor 6 (Traf6), TNF receptor associated factor 6 (traf6), TNF receptor-associated factor 6 (LOC551819), TNF receptor-associated factor 6 (traf6), TNF receptor associated factor 6 S homeolog (traf6.S), 2310003F17Rik, AI851288, C630032O20Rik, CG10961, Dmel\\CG10961, DTRAF2, dTRAF2, dTraf2, dtraf2, dTRAF6, fi15f02, GB10539, MGC:3310, RNF85, rnf85, TRAF, TRAF2, Traf2, traf6, TRAF6, wu:fi15f02, xtraf6, zgc:63704

Protein level used designations for TRAF6

  • E3 ubiquitin-protein ligase TRAF6
  • RING finger protein 85
  • TNF receptor-associated factor 6
  • interleukin-1 signal transducer
  • TNF receptor-associated factor 6-B
  • CG10961-PA
  • TNF-receptor-associated factor 2
  • Traf6-PA
  • TNF-receptor associated factor 6
  • TNF receptor-associated factor 6-like
  • TNF receptor-associated factor 6-A
  • TNF receptor-associated factor 6, E3 ubiquitin protein ligase
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