TPSAB1 Products
(Tryptase alpha/beta 1 (TPSAB1))
Categories
Tryptases comprise a family of trypsin-like serine proteases, the peptidase family S1. Tryptases are enzymatically active only as heparin-stabilized tetramers, and they are resistant to all known endogenous proteinase inhibitors. Several tryptase genes are clustered on chromosome 16p13.3. These genes are characterized by several distinct features. They have a highly conserved 3' UTR and contain tandem repeat sequences at the 5' flank and 3' UTR which are thought to play a role in regulation of the mRNA stability. These genes have an intron immediately upstream of the initiator Met codon, which separates the site of transcription initiation from protein coding sequence. This feature is characteristic of tryptases but is unusual in other genes. The alleles of this gene exhibit an unusual amount of sequence variation, such that the alleles were once thought to represent two separate genes, alpha and beta 1. Beta tryptases appear to be the main isoenzymes expressed in mast cells\; whereas in basophils, alpha tryptases predominate. Tryptases have been implicated as mediators in the pathogenesis of asthma and other allergic and inflammatory disorders. [provided by RefSeq, Jul 2008].
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Featured TPSAB1 Categories
TPSAB1 Antibodies
High quality antibodies with extensive validation data.
TPSAB1 ELISA Kits
Reliable ELISA kits for a wide range of species.
TPSAB1 Proteins
Proteins for various applications incl. WB, ELISA, IF etc.
Recommended TPSAB1 Antibodies
Product
Reactivity
Application
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Human
Application
WB, IHC, IP, ICC
Validations
- (6)
Cat. No.
ABIN7433105
Quantity
100 μL
Datasheet
Datasheet
Reactivity
Human
Application
WB, IHC, IP, ICC
Validations
- (6)
Cat. No.
ABIN7426172
Quantity
100 μL
Datasheet
Datasheet
Reactivity
Human
Application
WB, IHC, IP, ICC
Validations
- (6)
Cat. No.
ABIN7428305
Quantity
100 μL
Datasheet
Datasheet
Recommended TPSAB1 ELISA Kits
Product
Reactivity
Analytical Method
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Human
Analytical Method
Quantitative Sandwich ELISA
Validations
- (6)
- (6)
Cat. No.
ABIN6574250
Quantity
96 tests
Datasheet
Datasheet
Reactivity
Mouse
Analytical Method
Quantitative Sandwich ELISA
Validations
- (1)
- (1)
Cat. No.
ABIN6960219
Quantity
96 tests
Datasheet
Datasheet
Reactivity
Rat
Analytical Method
Quantitative Sandwich ELISA
Validations
- (1)
- (1)
Cat. No.
ABIN6960221
Quantity
96 tests
Datasheet
Datasheet
Recommended TPSAB1 Proteins
Product
Reactivity
Source
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Cynomolgus
Source
Escherichia coli (E. coli)
Validations
- (1)
Cat. No.
ABIN7275682
Quantity
100 μg
Datasheet
Datasheet
Reactivity
Human
Source
Wheat germ
Validations
- (1)
Cat. No.
ABIN1323462
Quantity
10 μg
Datasheet
Datasheet
Reactivity
Human
Source
Baculovirus infected Insect Cells
Validations
- (1)
Cat. No.
ABIN5855023
Quantity
50 μg
Datasheet
Datasheet
Latest Publications for our TPSAB1 products
: "Dengue virus-elicited tryptase induces endothelial permeability and shock." in: The Journal of clinical investigation, Vol. 129, Issue 10, pp. 4180-4193, (2020) (PubMed).: "Localization of cannabinoid receptors CB1, CB2, GPR55, and PPARα in the canine gastrointestinal tract." in: Histochemistry and cell biology, Vol. 150, Issue 2, pp. 187-205, (2018) (PubMed).
: "Altered Expression of IFN-λ2 in Allergic Airway Disorders and Identification of Its Cell Origins." in: Mediators of inflammation, Vol. 2016, pp. 5759496, (2016) (PubMed).
: "Circulating tryptase as a marker for subclinical atherosclerosis in obese subjects." in: PLoS ONE, Vol. 9, Issue 5, pp. e97014, (2015) (PubMed).
: "Peritoneal mast cell degranulation and gastrointestinal recovery in patients undergoing colorectal surgery." in: Neurogastroenterology and motility : the official journal of the European Gastrointestinal Motility Society, Vol. 27, Issue 6, pp. 764-74, (2015) (PubMed).
: "Tryptase and protease-activated receptor-2 stimulate scratching behavior in a murine model of ovalbumin-induced atopic-like dermatitis." in: International immunopharmacology, Vol. 28, Issue 1, pp. 507-12, (2015) (PubMed).
: "Elevated Serum Tryptase and Endothelin in Patients with ST Segment Elevation Myocardial Infarction: Preliminary Report." in: Mediators of inflammation, Vol. 2015, pp. 395173, (2015) (PubMed).
: "Effect of Auricular Acupressure on Uremic Pruritus in Patients Receiving Hemodialysis Treatment: A Randomized Controlled Trial." in: Evidence-based complementary and alternative medicine : eCAM, Vol. 2015, pp. 593196, (2015) (PubMed).
: "Improved liver function and relieved pruritus after 4-phenylbutyrate therapy in a patient with progressive familial intrahepatic cholestasis type 2." in: The Journal of pediatrics, Vol. 164, Issue 5, pp. 1219-1227.e3, (2014) (PubMed).
: "Beetroot (Beta vulgaris L.) extract ameliorates gentamicin-induced nephrotoxicity associated oxidative stress, inflammation, and apoptosis in rodent model." in: Mediators of inflammation, Vol. 2014, pp. 983952, (2014) (PubMed).
Synonyms and alternative names related to TPSAB1
tryptase alpha/beta 1 (TPSAB1), tryptase (MCT7), tryptase alpha/beta 1 (tpsab1), tryptase beta 2 (gene/pseudogene) (TPSB2), tryptase alpha/beta 1 (Tpsab1), tryptase beta 2 (Tpsb2), AV011504, Mcp-6, Mcp-7, Mcp6, Mcp7, Mcpt6, Mcpt7, MMCP-6, MMCP-7, PMCT7, rMCP-7, TPS1, TPS2, tpsab1, TPSB1, tryptaseB, tryptaseCProtein level used designations for TPSAB1
- mast cell alpha II tryptase
- mast cell beta I tryptase
- tryptase I
- tryptase alpha II
- tryptase alpha-1
- tryptase alpha/beta-1
- tryptase beta 1
- tryptase beta I
- tryptase beta-1
- tryptase-1
- tryptase-I
- tryptase-III
- tryptase alpha/beta 1
- mast cell tryptase beta II
- mast cell tryptase beta III
- tryptase beta-2
- mast cell protease 7
- mast cell-restricted serine protease 7
- tryptase
- MMCP-7
- tryptase, skin
- mast cell protease 6
- tryptase-2
- rMCP-6
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