TPMT Products
(Thiopurine S-Methyltransferase (TPMT))
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This gene encodes the enzyme that metabolizes thiopurine drugs via S-adenosyl-L-methionine as the S-methyl donor and S-adenosyl-L-homocysteine as a byproduct. Thiopurine drugs such as 6-mercaptopurine are used as chemotherapeutic agents. Genetic polymorphisms that affect this enzymatic activity are correlated with variations in sensitivity and toxicity to such drugs within individuals. A pseudogene for this locus is located on chromosome 18q. [provided by RefSeq, Jul 2008].
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Featured TPMT Categories
TPMT Antibodies
High quality antibodies with extensive validation data.
TPMT ELISA Kits
Reliable ELISA kits for a wide range of species.
TPMT Proteins
Proteins for various applications incl. WB, ELISA, IF etc.
Recommended TPMT Antibodies
Product
Reactivity
Application
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Human
Application
WB, IHC, IP, ICC
Validations
- (7)
Cat. No.
ABIN7435148
Quantity
100 μL
Datasheet
Datasheet
Reactivity
Human
Application
WB, ELISA, IF, IHC (p)
Validations
- (2)
- (5)
Cat. No.
ABIN563239
Quantity
100 μg
Datasheet
Datasheet
Reactivity
Dog, Human
Application
WB, IHC, IHC (p), FACS
Validations
- (6)
Cat. No.
ABIN1501480
Quantity
100 μL
Datasheet
Datasheet
Recommended TPMT ELISA Kits
Product
Reactivity
Analytical Method
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Human
Analytical Method
Quantitative Sandwich ELISA
Validations
- (1)
Cat. No.
ABIN6970609
Quantity
96 tests
Datasheet
Datasheet
Reactivity
Human
Analytical Method
Quantitative Sandwich ELISA
Validations
- (1)
Cat. No.
ABIN6962695
Quantity
96 tests
Datasheet
Datasheet
Reactivity
Human
Analytical Method
Quantitative Sandwich ELISA
Validations
- (1)
Cat. No.
ABIN6959901
Quantity
96 tests
Datasheet
Datasheet
Recommended TPMT Proteins
Product
Reactivity
Source
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Human
Source
Wheat germ
Validations
- (1)
Cat. No.
ABIN1323441
Quantity
10 μg
Datasheet
Datasheet
Reactivity
Human
Source
Escherichia coli (E. coli)
Validations
- (1)
Cat. No.
ABIN934951
Quantity
100 μg
Datasheet
Datasheet
Reactivity
Human
Source
Escherichia coli (E. coli)
Validations
Cat. No.
ABIN7396802
Quantity
100 μg
Datasheet
Datasheet
Latest Publications for our TPMT products
: "Sorting nexin 27 interacts with multidrug resistance-associated protein 4 (MRP4) and mediates internalization of MRP4." in: The Journal of biological chemistry, Vol. 287, Issue 18, pp. 15054-65, (2012) (PubMed).: "S-adenosylmethionine regulates thiopurine methyltransferase activity and decreases 6-mercaptopurine cytotoxicity in MOLT lymphoblasts." in: Biochemical pharmacology, Vol. 77, Issue 12, pp. 1845-53, (2009) (PubMed).
: "A novel gene delivery system for stable transfection of thiopurine-S-methyltransferase gene in versatile cell types." in: European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft für Pharmazeutische Verfahrenstechnik e.V, Vol. 69, Issue 1, pp. 23-30, (2008) (PubMed).
: "Human thiopurine S-methyltransferase pharmacogenetics: variant allozyme misfolding and aggresome formation." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 102, Issue 26, pp. 9394-9, (2005) (PubMed).
: "Stimulation of E2F1/DP1 transcriptional activity by MDM2 oncoprotein." in: Nature, Vol. 375, Issue 6533, pp. 691-4, (1995) (PubMed).
Synonyms and alternative names related to TPMT
thiopurine S-methyltransferase L homeolog (tpmt.L), thiopurine S-methyltransferase, tandem duplicate 2 (tpmt.2), thiopurine S-methyltransferase TpmT (tpmT), thiopurine S-methyltransferase (MCA0794), thiopurine S-methyltransferase (Pnap_4948), thiopurine S-methyltransferase (Hhal_1383), thiopurine S-methyltransferase (TK90_1044), thiopurine S-methyltransferase (Slit_1144), thiopurine S-methyltransferase (Tint_0842), Thiopurine S-methyltransferase (Fbal_3334), thiopurine S-methyltransferase (Celly_3188), thiopurine S-methyltransferase (Weevi_1737), Thiopurine S-methyltransferase (Psefu_2696), Thiopurine S-methyltransferase (Metme_3860), thiopurine methyltransferase (Tpmt), thiopurine S-methyltransferase (TPMT), thiopurine S-methyltransferase (Tpmt), AW106912, MGC84277, NHLRC1Protein level used designations for TPMT
- thiopurine S-methyltransferase
- Thiopurine S-methyltransferase
- S-adenosyl-L-methionine:thiopurine S-methyltransferase
- thiopurine methyltransferase
- NHL repeat containing 1
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