TPCN2 Products
(Two Pore Segment Channel 2 (TPCN2))
Categories
This gene encodes a putative cation-selective ion channel with two repeats of a six-transmembrane-domain. The protein localizes to lysosomal membranes and enables nicotinic acid adenine dinucleotide phosphate (NAADP) -induced calcium ion release from lysosome-related stores. This ubiquitously expressed gene has elevated expression in liver and kidney. Two common nonsynonymous SNPs in this gene strongly associate with blond versus brown hair pigmentation.[provided by RefSeq, Dec 2009].
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Featured TPCN2 Categories
TPCN2 Antibodies
High quality antibodies with extensive validation data.
TPCN2 ELISA Kits
Reliable ELISA kits for a wide range of species.
TPCN2 Proteins
Proteins for various applications incl. WB, ELISA, IF etc.
Recommended TPCN2 Antibodies
Product
Reactivity
Application
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Human
Application
ELISA, IHC
Validations
- (2)
Cat. No.
ABIN570776
Quantity
100 μg
Datasheet
Datasheet
Reactivity
Human, Mouse, Rat
Application
WB, IHC, IF
Validations
- (3)
Cat. No.
ABIN7043872
Quantity
25 μL
Datasheet
Datasheet
Reactivity
Mouse
Application
WB, IHC
Validations
- (1)
Cat. No.
ABIN351016
Quantity
500 μg
Datasheet
Datasheet
Recommended TPCN2 ELISA Kits
Product
Reactivity
Analytical Method
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Mouse
Analytical Method
Quantitative Competition ELISA
Validations
Cat. No.
ABIN6199932
Quantity
96 tests
Datasheet
Datasheet
Reactivity
Human
Analytical Method
Quantitative Competition ELISA
Validations
Cat. No.
ABIN6199931
Quantity
96 tests
Datasheet
Datasheet
Recommended TPCN2 Proteins
Product
Reactivity
Source
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Human
Source
Tobacco (Nicotiana tabacum)
Validations
Cat. No.
ABIN3116758
Quantity
1 mg
Datasheet
Datasheet
Reactivity
Mouse
Source
Tobacco (Nicotiana tabacum)
Validations
Cat. No.
ABIN3125362
Quantity
1 mg
Datasheet
Datasheet
Reactivity
Mouse, Rat
Source
Escherichia coli (E. coli)
Validations
Cat. No.
ABIN2751820
Quantity
5 applications
Datasheet
Datasheet
Latest Publications for our TPCN2 products
: "Highly multiplexed immunofluorescence imaging of human tissues and tumors using t-CyCIF and conventional optical microscopes." in: eLife, Vol. 7, (2019) (PubMed).: "Characterization of Two-Pore Channel 2 by Nuclear Membrane Electrophysiology." in: Scientific reports, Vol. 6, pp. 20282, (2016) (PubMed).
: "VEGF-induced neoangiogenesis is mediated by NAADP and two-pore channel-2-dependent Ca2+ signaling." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 111, Issue 44, pp. E4706-15, (2014) (PubMed).
: "NAADP and the two-pore channel protein 1 participate in the acrosome reaction in mammalian spermatozoa." in: Molecular biology of the cell, Vol. 25, Issue 6, pp. 948-64, (2014) (PubMed).
: "NAADP mobilizes calcium from acidic organelles through two-pore channels." in: Nature, Vol. 459, Issue 7246, pp. 596-600, (2009) (PubMed).
Synonyms and alternative names related to TPCN2
two pore segment channel 2 (tpcn2), two pore segment channel 2 (Tpcn2), two pore segment channel 2 (TPCN2), two pore segment channel 2 L homeolog (tpcn2.L), two pore calcium channel protein 2 (LOC100444397), BC025890, D830047E22Rik, fi42c05, im:7140344, MGC115225, SHEP10, TPC2, wu:fi42c05, zgc:152898Protein level used designations for TPCN2
- two pore calcium channel protein 2
- voltage-dependent calcium channel protein TPC2
- two pore segment channel 2
- two pore calcium channel protein 2-like
- two-pore calcium channel protein 2
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