Topoisomerase II alpha Products
(Topoisomerase (DNA) II alpha 170kDa (TOP2A))
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This gene encodes a DNA topoisomerase, an enzyme that controls and alters the topologic states of DNA during transcription. This nuclear enzyme is involved in processes such as chromosome condensation, chromatid separation, and the relief of torsional stress that occurs during DNA transcription and replication. It catalyzes the transient breaking and rejoining of two strands of duplex DNA which allows the strands to pass through one another, thus altering the topology of DNA. Two forms of this enzyme exist as likely products of a gene duplication event. The gene encoding this form, alpha, is localized to chromosome 17 and the beta gene is localized to chromosome 3. The gene encoding this enzyme functions as the target for several anticancer agents and a variety of mutations in this gene have been associated with the development of drug resistance. Reduced activity of this enzyme may also play a role in ataxia-telangiectasia. [provided by RefSeq, Jul 2010].
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Featured Topoisomerase II alpha Categories
Topoisomerase II alpha Antibodies
High quality antibodies with extensive validation data.
Topoisomerase II alpha ELISA Kits
Reliable ELISA kits for a wide range of species.
Topoisomerase II alpha Proteins
Proteins for various applications incl. WB, ELISA, IF etc.
Recommended Topoisomerase II alpha Antibodies
Product
Reactivity
Application
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Human, Rat
Application
WB, ELISA, FACS, ICC
Validations
- (7)
Cat. No.
ABIN7193564
Quantity
100 μL
Datasheet
Datasheet
Reactivity
Mouse, Rat
Application
IHC, IF
Validations
- (12)
Cat. No.
ABIN7075937
Quantity
100 μL
Datasheet
Datasheet
Reactivity
Human, Mouse
Application
WB, IHC, IF, StM
Validations
- (7)
Cat. No.
ABIN6940773
Quantity
100 μg
Datasheet
Datasheet
Recommended Topoisomerase II alpha ELISA Kits
Product
Reactivity
Analytical Method
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Human
Analytical Method
Quantitative Sandwich ELISA
Validations
- (1)
Cat. No.
ABIN6970754
Quantity
96 tests
Datasheet
Datasheet
Reactivity
Human
Analytical Method
Qualitative Cell ELISA
Validations
Cat. No.
ABIN1380476
Quantity
2 x 96 tests
Datasheet
Datasheet
Reactivity
Human
Analytical Method
Qualitative Cell ELISA
Validations
Cat. No.
ABIN1380808
Quantity
2 x 96 tests
Datasheet
Datasheet
Recommended Topoisomerase II alpha Proteins
Product
Reactivity
Source
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Human
Source
Wheat germ
Validations
- (1)
Cat. No.
ABIN1323347
Quantity
10 μg
Datasheet
Datasheet
Reactivity
Human
Source
Escherichia coli (E. coli)
Validations
- (1)
Cat. No.
ABIN7013599
Quantity
100 μg
Datasheet
Datasheet
Reactivity
Human, Mouse, Rat
Source
Escherichia coli (E. coli)
Validations
Cat. No.
ABIN2751809
Quantity
5 applications
Datasheet
Datasheet
Latest Publications for our Topoisomerase II alpha products
: "Type IIB DNA topoisomerase is downregulated by trastuzumab and doxorubicin to synergize cardiotoxicity." in: Oncotarget, Vol. 9, Issue 5, pp. 6095-6108, (2018) (PubMed).: "Chromosome Scaffold is a Double-Stranded Assembly of Scaffold Proteins." in: Scientific reports, Vol. 5, pp. 11916, (2015) (PubMed).
: "Tumour expression of bladder cancer-associated urinary proteins." in: BJU international, Vol. 112, Issue 3, pp. 407-15, (2013) (PubMed).
: "Antibodies biotinylated using a synthetic Z-domain from protein A provide stringent in situ protein detection." in: The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society, Vol. 61, Issue 11, pp. 773-84, (2013) (PubMed).
: "DNA topoisomerase IIalpha is required for RNA polymerase II transcription on chromatin templates." in: Nature, Vol. 413, Issue 6854, pp. 435-8, (2001) (PubMed).
Synonyms and alternative names related to Topoisomerase II alpha
DNA topoisomerase II alpha (TOP2A), DNA topoisomerase II, alpha isozyme (Bm1_08705), topoisomerase (DNA) II alpha (Top2a), DNA topoisomerase II alpha (Top2a), topoisomerase (DNA) II alpha (TOP2A), Zincin-like metalloproteases family protein (AT5G10540), DNA topoisomerase II alpha (top2a), F12B17.110, F12B17_110, fc08c07, thimet metalloendopeptidase 2, Top-2, TOP-2, TOP2, TOP2A, TP2A, wu:fc08c07Protein level used designations for Topoisomerase II alpha
- DNA gyrase
- DNA topoisomerase (ATP-hydrolyzing)
- DNA topoisomerase 2-alpha
- DNA topoisomerase II, 170 kD
- DNA topoisomerase II, alpha isozyme
- DNA Topoisomerase II alpha
- topoisomerase (DNA) 2 alpha
- DNA topoisomeraseII_alpha
- topoisomerase (DNA) II alpha
- Thimet metalloendopeptidase 2
- Zincin-like metalloproteases family protein 2
- topoisomerase 2
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