Topoisomerase I Products
(Topoisomerase (DNA) I (TOP1))
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This gene encodes a DNA topoisomerase, an enzyme that controls and alters the topologic states of DNA during transcription. This enzyme catalyzes the transient breaking and rejoining of a single strand of DNA which allows the strands to pass through one another, thus altering the topology of DNA. This gene is localized to chromosome 20 and has pseudogenes which reside on chromosomes 1 and 22. [provided by RefSeq, Jul 2008].
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Featured Topoisomerase I Categories
Topoisomerase I Antibodies
High quality antibodies with extensive validation data.
Topoisomerase I ELISA Kits
Reliable ELISA kits for a wide range of species.
Topoisomerase I Proteins
Proteins for various applications incl. WB, ELISA, IF etc.
Recommended Topoisomerase I Antibodies
Product
Reactivity
Application
Validations
Cat. No.
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Datasheet
Reactivity
Human
Application
WB, ELISA, IHC (p)
Validations
- (1)
- (8)
Cat. No.
ABIN563222
Quantity
100 μg
Datasheet
Datasheet
Reactivity
Human
Application
WB, IHC, IF, IP
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- (7)
Cat. No.
ABIN7270850
Quantity
100 μL
Datasheet
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Reactivity
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- (5)
Cat. No.
ABIN7127850
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Recommended Topoisomerase I ELISA Kits
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Reactivity
Analytical Method
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Cat. No.
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Reactivity
Rat
Analytical Method
Quantitative Sandwich ELISA
Validations
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- (1)
Cat. No.
ABIN6960049
Quantity
96 tests
Datasheet
Datasheet
Reactivity
Human
Analytical Method
Quantitative Sandwich ELISA
Validations
- (1)
Cat. No.
ABIN6970752
Quantity
96 tests
Datasheet
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Reactivity
Mouse
Analytical Method
Quantitative Sandwich ELISA
Validations
- (1)
Cat. No.
ABIN6970753
Quantity
96 tests
Datasheet
Datasheet
Recommended Topoisomerase I Proteins
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Reactivity
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Cat. No.
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Reactivity
Human
Source
Wheat germ
Validations
- (1)
Cat. No.
ABIN1323345
Quantity
10 μg
Datasheet
Datasheet
Reactivity
Mouse
Source
Escherichia coli (E. coli)
Validations
Cat. No.
ABIN7413022
Quantity
100 μg
Datasheet
Datasheet
Reactivity
Human
Source
Escherichia coli (E. coli)
Validations
Cat. No.
ABIN7396097
Quantity
100 μg
Datasheet
Datasheet
Latest Publications for our Topoisomerase I products
: "High TDP43 expression is required for TRIM16-induced inhibition of cancer cell growth and correlated with good prognosis of neuroblastoma and breast cancer patients." in: Cancer letters, Vol. 374, Issue 2, pp. 315-23, (2016) (PubMed).: "Inhibitory effects of lapachol on rat C6 glioma in vitro and in vivo by targeting DNA topoisomerase I and topoisomerase II." in: Journal of experimental & clinical cancer research : CR, Vol. 35, Issue 1, pp. 178, (2016) (PubMed).
: "TRIM16 overexpression induces apoptosis through activation of caspase-2 in cancer cells." in: Apoptosis : an international journal on programmed cell death, Vol. 18, Issue 5, pp. 639-51, (2013) (PubMed).
: "AID-induced decrease in topoisomerase 1 induces DNA structural alteration and DNA cleavage for class switch recombination." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 106, Issue 52, pp. 22375-80, (2010) (PubMed).
: "The DNA sequence and comparative analysis of human chromosome 20. ..." in: Nature, Vol. 414, Issue 6866, pp. 865-71, (2002) (PubMed).
: "DNA topoisomerase I: customs officer at the border between DNA and RNA worlds?" in: Journal of molecular medicine (Berlin, Germany), Vol. 75, Issue 11-12, pp. 786-800, (1998) (PubMed).
: "Structure of the human type I DNA topoisomerase gene." in: The Journal of biological chemistry, Vol. 266, Issue 15, pp. 9610-6, (1991) (PubMed).
: "Decreased expression of DNA topoisomerase I in camptothecin-resistant tumor cell lines as determined by a monoclonal antibody." in: Cancer research, Vol. 50, Issue 21, pp. 6925-30, (1990) (PubMed).
Synonyms and alternative names related to Topoisomerase I
Topoisomerase 1 (Top1), DNA topoisomerase I (top1), DNA topoisomerase I (topA), DNA topoisomerase I (ZMO1193), DNA topoisomerase I (MRAD2831_RS63095), DNA topoisomerase I (Lferr_0016), DNA topoisomerase I (PC1_2015), DNA topoisomerase I (Za10_0136), DNA topoisomerase I (Gbro_0575), DNA topoisomerase I (Dd586_2108), DNA topoisomerase I (Kvar_3044), DNA topoisomerase I (Alvin_2069), DNA topoisomerase I (Dacet_0849), DNA topoisomerase I (Mrub_1615), DNA topoisomerase I (Arnit_2962), DNA topoisomerase I (Ndas_4953), DNA topoisomerase I (Trad_2377), DNA topoisomerase I (Acear_1653), DNA topoisomerase I (Mahau_0844), DNA topoisomerase I (Mesop_4109), DNA topoisomerase I (Thein_1586), DNA topoisomerase I (Theth_0241), DNA topoisomerase I alpha (TOP1ALPHA), DNA topoisomerase 1 (top-1), DNA topoisomerase I (TOP1), topoisomerase (DNA) I (Top1), DNA topoisomerase I (Top1), DNA topoisomerase I, gene 1 L homeolog (top1.1.L), Ab2-086, AI467334, CG6146, D130064I21Rik, Dmel\\CG6146, DNA topoisomerase 1 beta, DNA topoisomerase I alpha, dTopoI, l(1)G0134, l(1)G0201, l(1)G0229, l(1)G0278, l(1)top1, MGO1, MGOUN 1, MTE17.1, MTE17_1, Top-1, TOP1, top1, TOP1BETA, TopI, TOPI, topi, Topo I, TopoI, topo I, topoI, TOPOISOMERASE 1Protein level used designations for Topoisomerase I
- CG6146-PA
- CG6146-PB
- CG6146-PC
- CG6146-PD
- Top1-PA
- Top1-PB
- Top1-PC
- Top1-PD
- topoisomerase 1
- topoisomerase I
- topoisomerase1
- type I topoisomerase
- DNA topoisomerase I
- DNA topoisomerase 1
- type I DNA topoisomerase
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