TOPBP1 Products
(Topoisomerase (DNA) II Binding Protein 1 (TOPBP1))
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This gene encodes a binding protein which interacts with the C-terminal region of topoisomerase II beta. This interaction suggests a supportive role for this protein in the catalytic reactions of topoisomerase II beta through transient breakages of DNA strands. [provided by RefSeq, Jul 2008].
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Featured TOPBP1 Categories
TOPBP1 Antibodies
High quality antibodies with extensive validation data.
TOPBP1 Proteins
Proteins for various applications incl. WB, ELISA, IF etc.
Recommended TOPBP1 Antibodies
Product
Reactivity
Application
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Human
Application
WB
Validations
- (1)
- (4)
Cat. No.
ABIN6149398
Quantity
100 μL
Datasheet
Datasheet
Reactivity
Human, Mouse
Application
WB, IHC, IF
Validations
- (3)
Cat. No.
ABIN7261736
Quantity
200 μL
Datasheet
Datasheet
Reactivity
Human
Application
WB, ELISA
Validations
- (3)
Cat. No.
ABIN1774839
Quantity
100 μg
Datasheet
Datasheet
Recommended TOPBP1 Proteins
Product
Reactivity
Source
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Human
Source
Wheat germ
Validations
- (1)
Cat. No.
ABIN1323353
Quantity
10 μg
Datasheet
Datasheet
Reactivity
Human
Source
Escherichia coli (E. coli)
Validations
Cat. No.
ABIN7419580
Quantity
100 μg
Datasheet
Datasheet
Reactivity
Mouse
Source
Escherichia coli (E. coli)
Validations
Cat. No.
ABIN7419823
Quantity
100 μg
Datasheet
Datasheet
Latest Publications for our TOPBP1 products
: "Two novel LRR-only proteins in Chlamys farreri: Similar in structure, yet different in expression profile and pattern recognition." in: Developmental and comparative immunology, Vol. 59, pp. 99-109, (2017) (PubMed).: "HUWE1 interacts with PCNA to alleviate replication stress." in: EMBO reports, Vol. 17, Issue 6, pp. 874-86, (2016) (PubMed).
: "ATR mediates a checkpoint at the nuclear envelope in response to mechanical stress." in: Cell, Vol. 158, Issue 3, pp. 633-46, (2014) (PubMed).
: "Akt switches TopBP1 function from checkpoint activation to transcriptional regulation through phosphoserine binding-mediated oligomerization." in: Molecular and cellular biology, Vol. 33, Issue 23, pp. 4685-700, (2013) (PubMed).
: "A novel interplay between the Fanconi anemia core complex and ATR-ATRIP kinase during DNA cross-link repair." in: Nucleic acids research, Vol. 41, Issue 14, pp. 6930-41, (2013) (PubMed).
: "Proteomic identification of PSF and p54(nrb) as TopBP1-interacting proteins." in: Journal of cellular biochemistry, Vol. 113, Issue 5, pp. 1744-53, (2012) (PubMed).
: "The N-terminus of the human RecQL4 helicase is a homeodomain-like DNA interaction motif." in: Nucleic acids research, Vol. 40, Issue 17, pp. 8309-24, (2012) (PubMed).
: "Neurogenesis requires TopBP1 to prevent catastrophic replicative DNA damage in early progenitors." in: Nature neuroscience, Vol. 15, Issue 6, pp. 819-26, (2012) (PubMed).
: "The atr protein kinase controls UV-dependent upregulation of p16INK4A through inhibition of Skp2-related polyubiquitination/degradation." in: Molecular cancer research : MCR, Vol. 9, Issue 3, pp. 311-9, (2011) (PubMed).
: "Serotype-specific inactivation of the cellular DNA damage response during adenovirus infection." in: Journal of virology, Vol. 85, Issue 5, pp. 2201-11, (2011) (PubMed).
Synonyms and alternative names related to TOPBP1
DNA topoisomerase II binding protein 1 (Topbp1), DNA topoisomerase II binding protein 1 (topbp1), topoisomerase (DNA) II binding protein 1 (TOPBP1), DNA topoisomerase II binding protein 1 (TOPBP1), dna topoisomerase ii binding protein 1 (IC) (topbp1), transcription coactivator (MEI1), topoisomerase (DNA) II binding protein 1 (Topbp1), DNA topoisomerase II binding protein 1 L homeolog (topbp1.L), 1110031N14Rik, 2810429C13Rik, AI256758, cut5, D430026L04Rik, F2P24.3, F2P24_3, meiosis defective 1, mKIAA0259, mus101, RGD1562949, TOP2BP1, top2bp1, TOPBP1, TopBP1-A, TopBP1-B, Xmus101, XtopBPProtein level used designations for TOPBP1
- DNA topoisomerase 2-binding protein 1
- topoisomerase (DNA) II beta binding protein
- topoisomerase (DNA) II binding protein 1
- dna topoisomerase ii binding protein 1 (IC)
- DNA topoisomerase 2-binding protein 1-like
- DNA topoisomerase II-beta-binding protein 1
- DNA topoisomerase II-binding protein 1
- Cut5-related protein
- DNA topoisomerase 2-binding protein 1-A
- DNA topoisomerase 2-binding protein 1-B
- DNA topoisomerase II-binding protein 1-A
- DNA topoisomerase II-binding protein 1-B
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