TNKS Products
(Tankyrase, TRF1-Interacting Ankyrin-Related ADP-Ribose Polymerase (TNKS))
Categories
Poly-ADP-ribosyltransferase involved in various processes such as Wnt signaling pathway, telomere length and vesicle trafficking. Acts as an activator of the Wnt signaling pathway by mediating poly-ADP-ribosylation of AXIN1 and AXIN2, 2 ribosylated target proteins are recognized by RNF146, which mediates their ubiquitination and subsequent degradation. Also mediates poly-ADP-ribosylation of BLZF1 and CASC3, followed by recruitment of RNF146 and subsequent ubiquitination. Mediates poly-ADP-ribosylation of TERF1, thereby contributing to the regulation of telomere length. May also regulate vesicle trafficking and modulate the subcellular distribution of SLC2A4/GLUT4-vesicles.
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Featured TNKS Categories
TNKS Antibodies
High quality antibodies with extensive validation data.
TNKS ELISA Kits
Reliable ELISA kits for a wide range of species.
TNKS Proteins
Proteins for various applications incl. WB, ELISA, IF etc.
Recommended TNKS Antibodies
Product
Reactivity
Application
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Human
Application
WB, ELISA, IHC, IF
Validations
- (3)
Cat. No.
ABIN7171496
Quantity
100 μg
Datasheet
Datasheet
Reactivity
Human
Application
WB, ELISA, IHC (p)
Validations
- (3)
Cat. No.
ABIN563737
Quantity
100 μg
Datasheet
Datasheet
Reactivity
Cow, Dog, Guinea Pig, Horse, Human, Mouse, Rabbit, Rat
Application
WB, IHC
Validations
- (4)
Cat. No.
ABIN2778109
Quantity
100 μL
Datasheet
Datasheet
Recommended TNKS ELISA Kits
Product
Reactivity
Analytical Method
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Human
Analytical Method
Quantitative Sandwich ELISA
Validations
- (1)
Cat. No.
ABIN6970560
Quantity
96 tests
Datasheet
Datasheet
Reactivity
Human
Analytical Method
Quantitative Sandwich ELISA
Validations
- (1)
Cat. No.
ABIN6959862
Quantity
96 tests
Datasheet
Datasheet
Reactivity
Mouse
Analytical Method
Validations
Cat. No.
ABIN1160810
Quantity
96 tests
Datasheet
Datasheet
Recommended TNKS Proteins
Product
Reactivity
Source
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Human
Source
Wheat germ
Validations
- (1)
Cat. No.
ABIN1323269
Quantity
10 μg
Datasheet
Datasheet
Reactivity
Human
Source
Escherichia coli (E. coli)
Validations
Cat. No.
ABIN7397048
Quantity
100 μg
Datasheet
Datasheet
Reactivity
Human
Source
Tobacco (Nicotiana tabacum)
Validations
Cat. No.
ABIN3095915
Quantity
1 mg
Datasheet
Datasheet
Latest Publications for our TNKS products
: "Shorter telomere length, higher telomerase activity in association with tankyrase gene polymorphism contribute to high-altitude pulmonary edema." in: Human molecular genetics, Vol. 29, Issue 18, pp. 3094-3106, (2020) (PubMed).: "Tankyrase 1 as a target for telomere-directed molecular cancer therapeutics." in: Cancer cell, Vol. 7, Issue 1, pp. 25-37, (2005) (PubMed).
: "Tankyrase-2 oligomerizes with tankyrase-1 and binds to both TRF1 (telomere-repeat-binding factor 1) and IRAP (insulin-responsive aminopeptidase)." in: The Biochemical journal, Vol. 361, Issue Pt 3, pp. 451-9, (2002) (PubMed).
: "Identification of a novel human tankyrase through its interaction with the adaptor protein Grb14." in: The Journal of biological chemistry, Vol. 276, Issue 20, pp. 17172-80, (2001) (PubMed).
: "Tankyrase promotes telomere elongation in human cells." in: Current biology : CB, Vol. 10, Issue 20, pp. 1299-302, (2001) (PubMed).
Synonyms and alternative names related to TNKS
tankyrase, TRF1-interacting ankyrin-related ADP-ribose polymerase b (tnksb), tankyrase (TNKS), tankyrase, TRF1-interacting ankyrin-related ADP-ribose polymerase (Tnks), tankyrase, TRF1-interacting ankyrin-related ADP-ribose polymerase 2 S homeolog (tnks2.S), tankyrase (Tnks), 4930554K12Rik, AI662855, ARTD5, C86528, D130072O21Rik, mTNKS1, PARP-5a, PARP5A, PARPL, pART5, TANK1, tankyrase-1, TIN1, TINF1, TNKS1, wu:fe02c12Protein level used designations for TNKS
- fe02c12
- tankyrase 1
- ADP-ribosyltransferase diphtheria toxin-like 5
- TANK1
- TNKS-1
- TRF1-interacting ankyrin-related ADP-ribose polymerase
- poly [ADP-ribose] polymerase 5A
- tankyrase I
- tankyrase-1
- TRF1-interacting ankyrin-related ADP-ribose polymerase 1
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