TNFSF9 Products
(Tumor Necrosis Factor (Ligand) Superfamily, Member 9 (TNFSF9))
Categories
The protein encoded by this gene is a cytokine that belongs to the tumor necrosis factor (TNF) ligand family. This transmembrane cytokine is a bidirectional signal transducer that acts as a ligand for TNFRSF9/4-1BB, which is a costimulatory receptor molecule in T lymphocytes. This cytokine and its receptor are involved in the antigen presentation process and in the generation of cytotoxic T cells. The receptor TNFRSF9/4-1BB is absent from resting T lymphocytes but rapidly expressed upon antigenic stimulation. The ligand encoded by this gene, TNFSF9/4-1BBL, has been shown to reactivate anergic T lymphocytes in addition to promoting T lymphocyte proliferation. This cytokine has also been shown to be required for the optimal CD8 responses in CD8 T cells. This cytokine is expressed in carcinoma cell lines, and is thought to be involved in T cell-tumor cell interaction.[provided by RefSeq, Oct 2008].
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Featured TNFSF9 Categories
TNFSF9 Antibodies
High quality antibodies with extensive validation data.
TNFSF9 ELISA Kits
Reliable ELISA kits for a wide range of species.
TNFSF9 Proteins
Proteins for various applications incl. WB, ELISA, IF etc.
Recommended TNFSF9 Antibodies
Product
Reactivity
Application
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Human, Mouse, Rat
Application
WB, ELISA, ICC, IF (cc), IF (p), IHC (p), IHC (fro)
Validations
- (3)
- (1)
Cat. No.
ABIN705056
Quantity
100 μL
Datasheet
Datasheet
Reactivity
Human
Application
WB, IHC, IP, ICC
Validations
- (7)
Cat. No.
ABIN7441109
Quantity
100 μL
Datasheet
Datasheet
Reactivity
Mouse
Application
WB, IHC, IP, ICC
Validations
- (4)
Cat. No.
ABIN7443173
Quantity
100 μL
Datasheet
Datasheet
Recommended TNFSF9 ELISA Kits
Product
Reactivity
Analytical Method
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Mouse
Analytical Method
Quantitative Sandwich ELISA
Validations
- (1)
Cat. No.
ABIN6970952
Quantity
96 tests
Datasheet
Datasheet
Reactivity
Human
Analytical Method
Quantitative Sandwich ELISA
Validations
- (1)
Cat. No.
ABIN6960265
Quantity
96 tests
Datasheet
Datasheet
Reactivity
Human
Analytical Method
Quantitative Sandwich ELISA
Validations
- (1)
Cat. No.
ABIN4881698
Quantity
96 tests
Datasheet
Datasheet
Recommended TNFSF9 Proteins
Product
Reactivity
Source
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Human
Source
HEK-293 Cells
Validations
- (4)
Cat. No.
ABIN7273929
Quantity
100 μg
Datasheet
Datasheet
Reactivity
Cynomolgus
Source
HEK-293 Cells
Validations
- (3)
Cat. No.
ABIN7273927
Quantity
100 μg
Datasheet
Datasheet
Reactivity
Human
Source
HEK-293 Cells
Validations
- (3)
Cat. No.
ABIN7273928
Quantity
100 μg
Datasheet
Datasheet
Latest Publications for our TNFSF9 products
: "Single-Cell RNA-Seq Reveals the Transcriptional Landscape and Heterogeneity of Aortic Macrophages in Murine Atherosclerosis." in: Circulation research, Vol. 122, Issue 12, pp. 1661-1674, (2019) (PubMed).: "Crystal structure of the human 4-1BB/4-1BBL complex." in: The Journal of biological chemistry, Vol. 293, Issue 25, pp. 9880-9891, (2018) (PubMed).
: "The structure of the trimer of human 4-1BB ligand is unique among members of the tumor necrosis factor superfamily." in: The Journal of biological chemistry, Vol. 285, Issue 12, pp. 9202-10, (2010) (PubMed).
: "Inhibition of proliferation and induction of apoptosis in multiple myeloma cell lines by CD137 ligand signaling." in: PLoS ONE, Vol. 5, Issue 5, pp. e10845, (2010) (PubMed).
: "Mantle cell lymphomas acquire increased expression of CCL4, CCL5 and 4-1BB-L implicated in cell survival." in: International journal of cancer, Vol. 118, Issue 8, pp. 2092-7, (2006) (PubMed).
: "Production of recombinant human trimeric CD137L (4-1BBL). Cross-linking is essential to its T cell co-stimulation activity." in: The Journal of biological chemistry, Vol. 280, Issue 50, pp. 41472-81, (2005) (PubMed).
: "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). ..." in: Genome research, Vol. 14, Issue 10B, pp. 2121-7, (2004) (PubMed).
: "[Binding between alpha 1A-adrenergic receptor and segment of bone morphogenetic protein-1 in human embryonic cell 293]." in: Sheng li xue bao : [Acta physiologica Sinica], Vol. 55, Issue 6, pp. 692-8, (2003) (PubMed).
: "Critical contribution of OX40 ligand to T helper cell type 2 differentiation in experimental leishmaniasis." in: The Journal of experimental medicine, Vol. 191, Issue 2, pp. 375-80, (2000) (PubMed).
: "Amplification of tumor immunity by gene transfer of the co-stimulatory 4-1BB ligand: synergy with the CD28 co-stimulatory pathway." in: European journal of immunology, Vol. 28, Issue 3, pp. 1116-21, (1998) (PubMed).
Synonyms and alternative names related to TNFSF9
TNF superfamily member 9 (Tnfsf9), TNF superfamily member 9 (LOC476729), TNF superfamily member 9 (TNFSF9), tumor necrosis factor (ligand) superfamily, member 9 (Tnfsf9), 4-1BB-L, 4-1BBL, AI848817, Cd137l, CD137L, Ly63l, TNFSF9Protein level used designations for TNFSF9
- costimulatory molecule
- tumor necrosis factor (ligand) superfamily, member 9
- 4-1BB ligand
- tumor necrosis factor ligand superfamily member 9
- 4-1BBL
- homolog of mouse 4-1BB-L
- receptor 4-1BB ligand
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