For best experience we recommend to activate Javascript in your browser.

TNF Receptor Superfamily, Member 6 Proteins

(TNF Receptor Superfamily, Member 6 (FAS))

The protein encoded by this gene is a member of the TNF-receptor superfamily. This receptor contains a death domain. It has been shown to play a central role in the physiological regulation of programmed cell death, and has been implicated in the pathogenesis of various malignancies and diseases of the immune system. The interaction of this receptor with its ligand allows the formation of a death-inducing signaling complex that includes Fas-associated death domain protein (FADD), caspase 8, and caspase 10. The autoproteolytic processing of the caspases in the complex triggers a downstream caspase cascade, and leads to apoptosis. This receptor has been also shown to activate NF-kappaB, MAPK3/ERK1, and MAPK8/JNK, and is found to be involved in transducing the proliferating signals in normal diploid fibroblast and T cells. Several alternatively spliced transcript variants have been described, some of which are candidates for nonsense-mediated mRNA decay (NMD). The isoforms lacking the transmembrane domain may negatively regulate the apoptosis mediated by the full length isoform. [provided by RefSeq, Mar 2011].

recommended

FAS Protein (AA 26-173) (Fc Tag) (ABIN7274589)

FAS Origin: Human Host: HEK-293 Cells Recombinant > 95 % as determined by Tris-Bis PAGE,> 95 % as determined by HPLC

Show Details

recommended

FAS Protein (AA 22-169) (Fc Tag) (ABIN7274590)

FAS Origin: Mouse Host: HEK-293 Cells Recombinant > 95 % as determined by Tris-Bis PAGE,> 95 % as determined by HPLC

Show Details

recommended

FAS Protein (AA 26-173) (His tag) (ABIN7274587)

FAS Origin: Human Host: HEK-293 Cells Recombinant > 95 % as determined by Tris-Bis PAGE

Show Details

TNF Receptor Superfamily, Member 6 Proteins by Origin

Find TNF Receptor Superfamily, Member 6 Proteins for a variety of species such as anti-Human TNF Receptor Superfamily, Member 6, anti-Mouse TNF Receptor Superfamily, Member 6, anti-Rat TNF Receptor Superfamily, Member 6. The species listed below are among those available. Click on a link to go to the corresponding products.

TNF Receptor Superfamily, Member 6 Proteins by Source

Here you will find TNF Receptor Superfamily, Member 6 Proteins proteins organized by several key sources. By clicking on a link, you can access the products. For additional sources, please use our search function.

TNF Receptor Superfamily, Member 6 Proteins by Protein Type

Here you can find TNF Receptor Superfamily, Member 6 Proteins proteins categorized by available protein types. Additional protein types can be located using our search function.

TNF Receptor Superfamily, Member 6 Proteins by Application

Find TNF Receptor Superfamily, Member 6 Proteins validated for a specific application such as SDS, WB, Imm, PC. Some of the available applications are listed below. Click on a link to go to the corresponding products.

TNF Receptor Superfamily, Member 6 Proteins by Biological Activity

Find TNF Receptor Superfamily, Member 6 Proteins with a specific Biological Activity. The Biological Activity listed below are among those available. Click on a link to go to the corresponding products.

Popular TNF Receptor Superfamily, Member 6 Proteins

Product

Reactivity

Source

Validations

Cat. No.

Quantity

Datasheet

FAS Protein (AA 26-173) (Fc Tag)

Reactivity Human

Source HEK-293 Cells

Validations

Cat. No. ABIN7274589

Quantity 100 μg

Datasheet Datasheet

FAS Protein (AA 22-169) (Fc Tag)

Reactivity Mouse

Source HEK-293 Cells

Validations

Cat. No. ABIN7274590

Quantity 100 μg

Datasheet Datasheet

FAS Protein (AA 26-173) (His tag)

Reactivity Human

Source HEK-293 Cells

Validations

Cat. No. ABIN7274587

Quantity 100 μg

Datasheet Datasheet

FAS Protein (AA 25-169) (His-DYKDDDDK-Strep II Tag)

Reactivity Human

Source HEK-293T Cells

Validations

Cat. No. ABIN1353663

Quantity 25 μg

Datasheet Datasheet

FAS Protein (His tag)

Reactivity Mouse

Source Human Cells

Validations

Cat. No. ABIN7320747

Quantity 50 μg

Datasheet Datasheet

FAS Protein (AA 17-173) (His tag)

Reactivity Human

Source Escherichia coli (E. coli)

Validations

Cat. No. ABIN7125404

Quantity 50 μg

Datasheet Datasheet

FAS Protein (AA 1-335) (GST tag)

Reactivity Human

Source Wheat germ

Validations

Cat. No. ABIN1353664

Quantity 10 μg

Datasheet Datasheet

FAS Protein (AA 20-119) (GST tag)

Reactivity Human

Source Wheat germ

Validations

Cat. No. ABIN1353666

Quantity 10 μg

Datasheet Datasheet

FAS Protein (AA 26-173) (His tag)

Reactivity Human

Source Baculovirus infected Insect Cells

Validations

Cat. No. ABIN5854470

Quantity 50 μg

Datasheet Datasheet

FAS Protein (His tag)

Reactivity Rat

Source HEK-293 Cells

Validations

Cat. No. ABIN7321232

Quantity 100 μg

Datasheet Datasheet

FAS Protein (His tag)

Reactivity Mouse

Source HEK-293 Cells

Validations

Cat. No. ABIN7320430

Quantity 100 μg

Datasheet Datasheet

FAS Protein (AA 26-173) (Fc Tag)

Reactivity Human

Source HEK-293 Cells

Validations

Cat. No. ABIN2181070

Quantity 100 μg

Datasheet Datasheet

FAS Protein (AA 26-172)

Reactivity Human

Source HEK-293T Cells

Validations

Cat. No. ABIN2017774

Quantity 50 μg

Datasheet Datasheet

FAS Protein (AA 26-170) (Fc Tag)

Reactivity Human, Mouse

Source HEK-293 Cells

Validations

Cat. No. ABIN1344148

Quantity 50 μg

Datasheet Datasheet

FAS Protein

Reactivity Human

Source Escherichia coli (E. coli)

Validations

Cat. No. ABIN935361

Quantity 20 μg

Datasheet Datasheet

Latest Publications for our TNF Receptor Superfamily, Member 6 Proteins

Orlinick, Vaishnaw, Elkon, Chao: "Requirement of cysteine-rich repeats of the Fas receptor for binding by the Fas ligand." in: The Journal of biological chemistry, Vol. 272, Issue 46, pp. 28889-94, (1997) (PubMed).

Liles, Kiener, Ledbetter, Aruffo, Klebanoff: "Differential expression of Fas (CD95) and Fas ligand on normal human phagocytes: implications for the regulation of apoptosis in neutrophils." in: The Journal of experimental medicine, Vol. 184, Issue 2, pp. 429-40, (1996) (PubMed).

Tanaka, Suda, Takahashi, Nagata: "Expression of the functional soluble form of human fas ligand in activated lymphocytes." in: The EMBO journal, Vol. 14, Issue 6, pp. 1129-35, (1995) (PubMed).

Brunner, Mogil, LaFace, Yoo, Mahboubi, Echeverri, Martin, Force, Lynch, Ware: "Cell-autonomous Fas (CD95)/Fas-ligand interaction mediates activation-induced apoptosis in T-cell hybridomas." in: Nature, Vol. 373, Issue 6513, pp. 441-4, (1995) (PubMed).

Yang, Merćep, Ware, Ashwell: "Fas and activation-induced Fas ligand mediate apoptosis of T cell hybridomas: inhibition of Fas ligand expression by retinoic acid and glucocorticoids." in: The Journal of experimental medicine, Vol. 181, Issue 5, pp. 1673-82, (1995) (PubMed).

Cheng, Zhou, Liu, Shapiro, Brauer, Kiefer, Barr, Mountz: "Protection from Fas-mediated apoptosis by a soluble form of the Fas molecule." in: Science (New York, N.Y.), Vol. 263, Issue 5154, pp. 1759-62, (1994) (PubMed).

Takahashi, Tanaka, Brannan, Jenkins, Copeland, Suda, Nagata: "Generalized lymphoproliferative disease in mice, caused by a point mutation in the Fas ligand." in: Cell, Vol. 76, Issue 6, pp. 969-76, (1994) (PubMed).

Aliases for TNF Receptor Superfamily, Member 6 Proteins

Fas cell surface death receptor (FAS) Proteins
Fas (TNF receptor superfamily member 6) (Fas) Proteins
Fas cell surface death receptor (Fas) Proteins
Fas cell surface death receptor (fas) Proteins
AI196731 Proteins
ALPS1A Proteins
APO-1 Proteins
APO1 Proteins
APT1 Proteins
CD95 Proteins
FAS1 Proteins
FASTM Proteins
lpr Proteins
TNFR6 Proteins
TNFRSF6 Proteins
Tnfrsf6 Proteins

Did you look for something else?

You are here:

TNF Receptor Superfamily, Member 6 Proteins by Origin

TNF Receptor Superfamily, Member 6 Proteins by Source

TNF Receptor Superfamily, Member 6 Proteins by Protein Type

TNF Receptor Superfamily, Member 6 Proteins by Application

TNF Receptor Superfamily, Member 6 Proteins by Biological Activity

Popular TNF Receptor Superfamily, Member 6 Proteins

Latest Publications for our TNF Receptor Superfamily, Member 6 Proteins

Aliases for TNF Receptor Superfamily, Member 6 Proteins

Did you look for something else?

antibodies-online

genomics-online