This gene encodes a multifunctional proinflammatory cytokine that belongs to the tumor necrosis factor (TNF) superfamily. This cytokine is mainly secreted by macrophages. It can bind to, and thus functions through its receptors TNFRSF1A/TNFR1 and TNFRSF1B/TNFBR. This cytokine is involved in the regulation of a wide spectrum of biological processes including cell proliferation, differentiation, apoptosis, lipid metabolism, and coagulation. This cytokine has been implicated in a variety of diseases, including autoimmune diseases, insulin resistance, and cancer. Knockout studies in mice also suggested the neuroprotective function of this cytokine. [provided by RefSeq, Jul 2008].
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Latest Publications for our TNF alpha (Infliximab Biosimilar) products
Farkas, Rutka, Golovics, Végh, Lovász, Nyári, Gecse, Kolar, Bortlik, Duricova, Machkova, Hruba, Lukas, Mitrova, Malickova, Bálint, Nagy, Bor, Milassin, Szepes, Palatka, Lakatos, Lukas, Molnár: "Efficacy of Infliximab Biosimilar CT-P13 Induction Therapy on Mucosal Healing in Ulcerative Colitis." in: Journal of Crohn's & colitis, Vol. 10, Issue 11, pp. 1273-1278, (2017) (PubMed).
Bálint, Rutka, Végh, Kürti, Gecse, Banai, Bene, Gasztonyi, Kristóf, Lakatos, Miheller, Palatka, Patai, Salamon, Szamosi, Szepes, Tóth, Vincze, Bor, Milassin, Fábián, Nagy, Kolar, Bortlik, Duricova et al.: "Frequency and characteristics of infusion reactions during biosimilar infliximab treatment in inflammatory bowel diseases: results from Central European nationwide cohort. ..." in: Expert opinion on drug safety, Vol. 16, Issue 8, pp. 885-890, (2017) (PubMed).
Synonyms and alternative names related to TNF alpha (Infliximab Biosimilar)