TLK1 Products
(Tousled-Like Kinase 1 (TLK1))
Categories
The protein encoded by this gene is a serine/threonine kinase that may be involved in the regulation of chromatin assembly. The encoded protein is only active when it is phosphorylated, and this phosphorylation is cell cycle-dependent, with the maximal activity of this protein coming during S phase. The catalytic activity of this protein is diminished by DNA damage and by blockage of DNA replication. Three transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Nov 2011].
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Featured TLK1 Categories
TLK1 Antibodies
High quality antibodies with extensive validation data.
TLK1 Proteins
Proteins for various applications incl. WB, ELISA, IF etc.
Recommended TLK1 Antibodies
Product
Reactivity
Application
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Human
Application
WB, IHC (p)
Validations
- (1)
- (4)
Cat. No.
ABIN392685
Quantity
400 μL
Datasheet
Datasheet
Reactivity
Human
Application
WB, IF, IP, ICC
Validations
- (1)
- (3)
Cat. No.
ABIN2855507
Quantity
100 μL
Datasheet
Datasheet
Reactivity
Human
Application
WB, ELISA, IHC (p)
Validations
- (4)
Cat. No.
ABIN564253
Quantity
100 μg
Datasheet
Datasheet
Recommended TLK1 Proteins
Product
Reactivity
Source
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Human
Source
Wheat germ
Validations
- (1)
Cat. No.
ABIN1322843
Quantity
10 μg
Datasheet
Datasheet
Reactivity
Human
Source
Baculovirus infected Insect Cells
Validations
- (1)
Cat. No.
ABIN7317054
Quantity
50 μg
Datasheet
Datasheet
Reactivity
Human
Source
Insect Cells
Validations
Cat. No.
ABIN5509177
Quantity
10 μg
Datasheet
Datasheet
Latest Publications for our TLK1 products
: "DNA damage response and repair data with pharmacological modulators of Tousled." in: Data in brief, Vol. 7, pp. 1073-7, (2016) (PubMed).: "TLK1B mediated phosphorylation of Rad9 regulates its nuclear/cytoplasmic localization and cell cycle checkpoint." in: BMC molecular biology, Vol. 17, pp. 3, (2016) (PubMed).
: "Silencing of Tousled-like kinase 1 sensitizes cholangiocarcinoma cells to cisplatin-induced apoptosis." in: Cancer letters, Vol. 296, Issue 1, pp. 27-34, (2010) (PubMed).
: "Large-scale mapping of human protein-protein interactions by mass spectrometry. ..." in: Molecular systems biology, Vol. 3, pp. 89, (2007) (PubMed).
: "Suppression of Tousled-like kinase activity after DNA damage or replication block requires ATM, NBS1 and Chk1." in: Oncogene, Vol. 22, Issue 38, pp. 5927-37, (2003) (PubMed).
: "Phosphorylation of SNAP-23 by the novel kinase SNAK regulates t-SNARE complex assembly." in: Molecular biology of the cell, Vol. 10, Issue 12, pp. 4033-41, (2000) (PubMed).
Synonyms and alternative names related to TLK1
tousled like kinase 1 (TLK1), tousled-like kinase 1 (Tlk1), tousled-like kinase 1b (tlk1b), tousled like kinase 1 like (TLK1L), tousled-like kinase 1 (TLK1), serine/threonine-protein kinase TOUSLED (LOC542181), tousled-like kinase 1a (tlk1a), tousled like kinase 1 (tlk1), Serine/threonine-protein kinase tousled-like 1 (tlk-1), tousled like kinase 1 (Tlk1), 4930545J15Rik, DKFZp459L163, fb76h12, fe11e12, PKU-beta, si:dkey-88m1.1, si:dkey-251e16.4, tlk1, TLK1, wu:fb76h12, wu:fe11e12Protein level used designations for TLK1
- SNARE protein kinase SNAK
- serine threonine protein kinase
- serine/threonine-protein kinase tousled-like 1
- pKU-beta protein kinase
- serine/threonine-protein kinase tousled-like 1-B
- tousled-like kinase 1
- tousled-like kinase 1-B
- LOW QUALITY PROTEIN: serine/threonine-protein kinase tousled-like 1
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