TIE1 Products
(tyrosine Kinase with Immunoglobulin-Like and EGF-Like Domains 1 (TIE1))
Categories
This gene encodes a member of the tyrosine protein kinase family. The encoded protein plays a critical role in angiogenesis and blood vessel stability by inhibiting angiopoietin 1 signaling through the endothelial receptor tyrosine kinase Tie2. Ectodomain cleavage of the encoded protein relieves inhibition of Tie2 and is mediated by multiple factors including vascular endothelial growth factor. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Nov 2011].
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Featured TIE1 Categories
TIE1 Antibodies
High quality antibodies with extensive validation data.
TIE1 ELISA Kits
Reliable ELISA kits for a wide range of species.
TIE1 Proteins
Proteins for various applications incl. WB, ELISA, IF etc.
Recommended TIE1 Antibodies
Product
Reactivity
Application
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Human
Application
WB, ELISA, IHC
Validations
- (6)
Cat. No.
ABIN2683015
Quantity
100 μL
Datasheet
Datasheet
Reactivity
Human
Application
WB, ELISA, IHC (p), ICC, IHC (fro)
Validations
- (4)
Cat. No.
ABIN7442504
Quantity
100 μL
Datasheet
Datasheet
Reactivity
Human
Application
WB, ELISA, IHC (p), ICC, IHC (fro)
Validations
- (3)
Cat. No.
ABIN7431122
Quantity
100 μL
Datasheet
Datasheet
Recommended TIE1 ELISA Kits
Product
Reactivity
Analytical Method
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Human
Analytical Method
Quantitative Sandwich ELISA
Validations
- (6)
Cat. No.
ABIN6730883
Quantity
96 tests
Datasheet
Datasheet
Reactivity
Mouse
Analytical Method
Quantitative Sandwich ELISA
Validations
- (1)
Cat. No.
ABIN6960330
Quantity
96 tests
Datasheet
Datasheet
Reactivity
Zebrafish (Danio rerio)
Analytical Method
Quantitative Sandwich ELISA
Validations
- (1)
Cat. No.
ABIN1572722
Quantity
96 tests
Datasheet
Datasheet
Recommended TIE1 Proteins
Product
Reactivity
Source
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Human
Source
Human Cells
Validations
Cat. No.
ABIN1097646
Quantity
50 μg
Datasheet
Datasheet
Reactivity
Human
Source
Insect Cells
Validations
Cat. No.
ABIN1589962
Quantity
20 μg
Datasheet
Datasheet
Reactivity
Mouse
Source
Insect Cells
Validations
Cat. No.
ABIN1589958
Quantity
10 μg
Datasheet
Datasheet
Latest Publications for our TIE1 products
: "Structural basis of Tie2 activation and Tie2/Tie1 heterodimerization." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 114, Issue 17, pp. 4376-4381, (2017) (PubMed).: "Polydom Is an Extracellular Matrix Protein Involved in Lymphatic Vessel Remodeling." in: Circulation research, Vol. 120, Issue 8, pp. 1276-1288, (2017) (PubMed).
: "Endothelial destabilization by angiopoietin-2 via integrin β1 activation." in: Nature communications, Vol. 6, pp. 5962, (2015) (PubMed).
: "Autocrine role of angiopoietins during megakaryocytic differentiation." in: PLoS ONE, Vol. 7, Issue 7, pp. e39796, (2012) (PubMed).
: "Regulated proteolytic processing of Tie1 modulates ligand responsiveness of the receptor-tyrosine kinase Tie2." in: The Journal of biological chemistry, Vol. 282, Issue 42, pp. 30509-17, (2007) (PubMed).
: "Interaction between Tie receptors modulates angiogenic activity of angiopoietin2 in endothelial progenitor cells." in: Cardiovascular research, Vol. 72, Issue 3, pp. 394-402, (2006) (PubMed).
: "Functions of the activation loop in Csk protein-tyrosine kinase." in: The Journal of biological chemistry, Vol. 278, Issue 26, pp. 24072-7, (2003) (PubMed).
: "Tyrosine phosphorylation of I-kappa B kinase alpha/beta by protein kinase C-dependent c-Src activation is involved in TNF-alpha-induced cyclooxygenase-2 expression." in: Journal of immunology (Baltimore, Md. : 1950), Vol. 170, Issue 9, pp. 4767-75, (2003) (PubMed).
: "Corneal IL-8 expression following adenovirus infection is mediated by c-Src activation in human corneal fibroblasts." in: Journal of immunology (Baltimore, Md. : 1950), Vol. 170, Issue 12, pp. 6234-43, (2003) (PubMed).
: "Expansion of human SCID-repopulating cells under hypoxic conditions." in: The Journal of clinical investigation, Vol. 112, Issue 1, pp. 126-35, (2003) (PubMed).
Synonyms and alternative names related to TIE1
tyrosine kinase with immunoglobulin like and EGF like domains 1 (TIE1), tyrosine kinase with immunoglobulin-like and EGF-like domains 1 (Tie1), tyrosine-protein kinase receptor Tie-1 (CpipJ_CPIJ018933), endothelium-specific receptor tyrosine kinase 1 (tie1), D430008P04Rik, JTK14, TIE, tie-1Protein level used designations for TIE1
- tyrosine kinase with immunoglobulin and epidermal growth factor homology domains 1
- tyrosine-protein kinase receptor Tie-1
- tyrosine kinase receptor 1
- tyrosine kinase with immunoglobulin and epidermal growth factor homology domains
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