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TICAM1 Products

(Toll-Like Receptor Adaptor Molecule 1 (TICAM1))
This gene encodes an adaptor protein containing a Toll/interleukin-1 receptor (TIR) homology domain, which is an intracellular signaling domain that mediates protein-protein interactions between the Toll-like receptors (TLRs) and signal-transduction components. This protein is involved in native immunity against invading pathogens. It specifically interacts with toll-like receptor 3, but not with other TLRs, and this association mediates dsRNA induction of interferon-beta through activation of nuclear factor kappa-B, during an antiviral immune response. [provided by RefSeq, Jan 2012].

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Featured TICAM1 Categories

TICAM1 Antibodies

High quality antibodies with extensive validation data.

TICAM1 ELISA Kits

Reliable ELISA kits for a wide range of species.

TICAM1 Proteins

Proteins for various applications incl. WB, ELISA, IF etc.

Recommended TICAM1 Antibodies

Product
Reactivity
Application
Validations
Cat. No.
Quantity
Datasheet
Reactivity Human
Application WB, IHC, IP, ICC
Validations
  • (7)
Cat. No. ABIN7441424
Quantity 100 μL
Datasheet Datasheet
Reactivity Human
Application WB, ELISA
Validations
  • (5)
Cat. No. ABIN7189088
Quantity 100 μg
Datasheet Datasheet
Reactivity Mouse
Application WB, IHC, IP, ICC
Validations
  • (5)
Cat. No. ABIN7441427
Quantity 100 μL
Datasheet Datasheet

Recommended TICAM1 ELISA Kits

Product
Reactivity
Analytical Method
Validations
Cat. No.
Quantity
Datasheet
Reactivity Human
Analytical Method Quantitative Sandwich ELISA
Validations
  • (1)
Cat. No. ABIN6960044
Quantity 96 tests
Datasheet Datasheet
Reactivity Mouse
Analytical Method Quantitative Sandwich ELISA
Validations
  • (1)
Cat. No. ABIN6960045
Quantity 96 tests
Datasheet Datasheet
Reactivity Human
Analytical Method Quantitative Sandwich ELISA
Validations
Cat. No. ABIN5659371
Quantity 96 tests
Datasheet Datasheet

Recommended TICAM1 Proteins

Product
Reactivity
Source
Validations
Cat. No.
Quantity
Datasheet
Reactivity Human
Source Escherichia coli (E. coli)
Validations
  • (1)
Cat. No. ABIN7125415
Quantity 50 μg
Datasheet Datasheet
Reactivity Human
Source Wheat germ
Validations
  • (1)
Cat. No. ABIN1322755
Quantity 10 μg
Datasheet Datasheet
Reactivity Human
Source Escherichia coli (E. coli)
Validations
Cat. No. ABIN7408849
Quantity 100 μg
Datasheet Datasheet

Latest Publications for our TICAM1 products

Mlcochova, Winstone, Zuliani-Alvarez, Gupta: "TLR4-Mediated Pathway Triggers Interferon-Independent G0 Arrest and Antiviral SAMHD1 Activity in Macrophages." in: Cell reports, Vol. 30, Issue 12, pp. 3972-3980.e5, (2020) (PubMed).

Zhou, Qi, Wang, Zhang, Xu, Dong, Zhu, Li, Wang, Xu, Liu, Hu, Zhou, Chen, Su: "SjHSP60 induces CD4+ CD25+ Foxp3+ Tregs via TLR4-Mal-drived production of TGF-β in macrophages." in: Immunology and cell biology, Vol. 96, Issue 9, pp. 958-968, (2019) (PubMed).

Feng, Yang, Wu, Tang, Wei, Guo, He, Feng: "Atractylodes macrocephala polysaccharides regulate the innate immunity of colorectal cancer cells by modulating the TLR4 signaling pathway." in: OncoTargets and therapy, Vol. 12, pp. 7111-7121, (2019) (PubMed).

Kim, Beon, Lee, Park, Ahn, Kim, Park, Kim, Yuk, Kang, Lee, Jo, Seong, Kim: "Inositol polyphosphate multikinase promotes Toll-like receptor-induced inflammation by stabilizing TRAF6." in: Science advances, Vol. 3, Issue 4, pp. e1602296, (2017) (PubMed).

Popiolek-Barczyk, Piotrowska, Makuch, Mika: "Biphalin, a Dimeric Enkephalin, Alleviates LPS-Induced Activation in Rat Primary Microglial Cultures in Opioid Receptor-Dependent and Receptor-Independent Manners." in: Neural plasticity, Vol. 2017, pp. 3829472, (2017) (PubMed).

Yu, Wang, He, Wang, Gao, Ren, Shi et al.: "Curcumin exerts anti-inflammatory and antioxidative properties in 1-methyl-4-phenylpyridinium ion (MPP(+))-stimulated mesencephalic astrocytes by interference with TLR4 and downstream signaling ..." in: Cell stress & chaperones, Vol. 21, Issue 4, pp. 697-705, (2017) (PubMed).

Du, Qiao, Chen, Chen, Liu, Lin, Wang, Xie: "Toll-Like Receptor 4 Mediates Methamphetamine-Induced Neuroinflammation through Caspase-11 Signaling Pathway in Astrocytes." in: Frontiers in molecular neuroscience, Vol. 10, pp. 409, (2017) (PubMed).

Zhang, Xiang, Wang, Yan, Zhu, Guo, Sengupta, Chen, Loughran, Lu, Wang, Billiar et al.: "Interferon β (IFN-β) Production during the Double-stranded RNA (dsRNA) Response in Hepatocytes Involves Coordinated and Feedforward Signaling through Toll-like Receptor 3 (TLR3), RNA-dependent ..." in: The Journal of biological chemistry, Vol. 291, Issue 29, pp. 15093-107, (2016) (PubMed).

Hu, Cong, Chen, Qi, Wu, Zhou, Yoo, Li, Sun, Wu, Zhao, Chen, Yu, Du, Wang: "Synergy of TLR3 and 7 ligands significantly enhances function of DCs to present inactivated PRRSV antigen through TRIF/MyD88-NF-κB signaling pathway." in: Scientific reports, Vol. 6, pp. 23977, (2016) (PubMed).

Lan, Han, Li, Li, Gao, Cheng, Wan, Zhu, Wang: "Pinocembrin protects hemorrhagic brain primarily by inhibiting toll-like receptor 4 and reducing M1 phenotype microglia." in: Brain, behavior, and immunity, Vol. 61, pp. 326-339, (2016) (PubMed).

Synonyms and alternative names related to TICAM1

toll like receptor adaptor molecule 1 (TICAM1), toll-like receptor adaptor molecule 1 (Ticam1), toll-like receptor adaptor molecule 1 (ticam1), AW046014, AW547018, IIAE6, MyD88-3, PRVTIRB, TICAM-1, TRIF, trif

Protein level used designations for TICAM1

  • TIR domain containing adaptor inducing interferon-beta
  • TIR domain-containing adapter molecule 1
  • TIR domain-containing adapter protein inducing IFN-beta
  • proline-rich, vinculin and TIR domain-containing protein B
  • putative NF-kappa-B-activating protein 502H
  • toll-interleukin-1 receptor domain-containing adapter protein inducing interferon beta
  • toll-interleukin I receptor domain containing adaptor molecule 1
  • toll-like receptor adaptor molecule 1
  • TIR domain-containing adapter molecule 1-like
  • TIR domain-containing adaptor inducing interferon-beta
  • toll-interleukin 1 receptor domain-containing adapter protein inducing interferon-beta
  • TICAM-1
  • TIR-domain containing adaptor inducing IFN-beta
  • TRIF/TICAM1
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