THO Complex 5 Products
(THO Complex 5 (THOC5))
Categories
Component the THO subcomplex of the TREX complex. The TREX complex specifically associates with spliced mRNA and not with unspliced pre-mRNA. It is recruited to spliced mRNAs by a transcription-independent mechanism. Binds to mRNA upstream of the exon-junction complex (EJC) and is recruited in a splicing- and cap-dependent manner to a region near the 5' end of the mRNA where it functions in mRNA export. The recruitment occurs via an interaction between ALYREF/THOC4 and the cap-binding protein NCBP1. DDX39B functions as a bridge between ALYREF/THOC4 and the THO complex. Regulates the expression of myeloid transcription factors CEBPA, CEBPB and GAB2 by enhancing the levels of phosphatidylinositol 3,4,5-trisphosphate. May be involved in the differentiation of granulocytes and adipocytes. Essential for hematopoietic primitive cell survival and plays an integral role in monocytic development (By similarity).
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Featured THO Complex 5 Categories
THO Complex 5 Antibodies
High quality antibodies with extensive validation data.
THO Complex 5 Proteins
Proteins for various applications incl. WB, ELISA, IF etc.
Recommended THO Complex 5 Antibodies
Product
Reactivity
Application
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Human
Application
ELISA, IHC, IF
Validations
- (2)
Cat. No.
ABIN7172059
Quantity
100 μg
Datasheet
Datasheet
Reactivity
Human
Application
ELISA, WB, IF, ICC
Validations
- (1)
Cat. No.
ABIN6265558
Quantity
100 μL
Datasheet
Datasheet
Reactivity
Human
Application
WB
Validations
- (1)
Cat. No.
ABIN6149119
Quantity
100 μL
Datasheet
Datasheet
Recommended THO Complex 5 ELISA Kits
Product
Reactivity
Analytical Method
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Human
Analytical Method
Quantitative Sandwich ELISA
Validations
Cat. No.
ABIN6207985
Quantity
96 tests
Datasheet
Datasheet
Recommended THO Complex 5 Proteins
Product
Reactivity
Source
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Human
Source
Wheat germ
Validations
- (1)
Cat. No.
ABIN1322701
Quantity
10 μg
Datasheet
Datasheet
Latest Publications for our THO Complex 5 products
: "mRNA export through an additional cap-binding complex consisting of NCBP1 and NCBP3." in: Nature communications, Vol. 6, pp. 8192, (2015) (PubMed).: "An ataxia-telangiectasia-mutated (ATM) kinase mediated response to DNA damage down-regulates the mRNA-binding potential of THOC5." in: RNA (New York, N.Y.), Vol. 17, Issue 11, pp. 1957-66, (2011) (PubMed).
Synonyms and alternative names related to THO Complex 5
THO complex 5 (THOC5), THO complex 5 (Thoc5), THO complex 5 (thoc5), THO complex 5 S homeolog (thoc5.S), THO complex 5 L homeolog (thoc5.L), 1700060C24Rik, A430085L24Rik, C22orf19, fc54b09, Fmip, fmip, fSAP79, PK1.3, Sgk2, THOC5, thoc5, thoc5-a, thoc5-b, wu:fc54b09, zgc:56190, zgc:76912Protein level used designations for THO Complex 5
- Fms-interacting protein
- NF2/meningioma region protein pK1.3
- PP39.2
- THO complex subunit 5 homolog
- functional spliceosome-associated protein 79
- hTREX90
- placental protein 39.2
- Fms interacting protein
- fms-interacting protein
- serum/glucocorticoid regulated kinase 2
- protein C22orf19
- THO complex 5
- THO complex subunit 5 homolog-like
- THO complex subunit 5 homolog B
- THO complex subunit 5 homolog A
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