Thiamine Biosynthesis1 Proteins
(Thiamine Biosynthesis1 (THI1))
Involved in biosynthesis of the thiamine precursor thiazole. Catalyzes the conversion of NAD and glycine to adenosine diphosphate 5-(2-hydroxyethyl)-4-methylthiazole-2-carboxylic acid (ADT), an adenylated thiazole intermediate. The reaction includes an iron-dependent sulfide transfer from a conserved cysteine residue of the protein to a thiazole intermediate. The enzyme can only undergo a single turnover, which suggests it is a suicide enzyme. May have additional roles in adaptation to various stress conditions and in DNA damage tolerance.
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Thiamine Biosynthesis1 Proteins
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Synonyms and alternative names related to Thiamine Biosynthesis1
thiamine biosynthesis 1 (thi1), thi1-1Protein level used designations for Thiamine Biosynthesis1
- QCB2h02
- Sed2
- gnp_QCB2h02
- gpm589
- iger2b(thi)
- pcPOG1
- thiamine biosynthetic enzyme
- thiamine thiazole synthase 1, chloroplastic
- thiazole biosynthetic enzyme 1
- thiazole biosynthetic enzyme 1-1, chloroplastic
- uiu(pog1C)
- uiu1c(pog)
- uiu4
- uiu4(pog1c)
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