TGS1 Products
(Trimethylguanosine Synthase 1 (TGS1))
Categories
Catalyzes the 2 serial methylation steps for the conversion of the 7-monomethylguanosine (m(7)G) caps of snRNAs and snoRNAs to a 2,2,7-trimethylguanosine (m(2,2,7)G) cap structure. The enzyme is specific for guanine, and N7 methylation must precede N2 methylation. Hypermethylation of the m7G cap of U snRNAs leads to their concentration in nuclear foci, their colocalization with coilin and the formation of canonical Cajal bodies (CBs). Plays a role in transcriptional regulation (By similarity).
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Featured TGS1 Categories
TGS1 Antibodies
High quality antibodies with extensive validation data.
TGS1 Proteins
Proteins for various applications incl. WB, ELISA, IF etc.
Recommended TGS1 Antibodies
Product
Reactivity
Application
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Human
Application
ELISA, WB, IHC
Validations
- (4)
Cat. No.
ABIN7173394
Quantity
100 μL
Datasheet
Datasheet
Reactivity
Human
Application
ELISA, WB, IHC
Validations
- (2)
Cat. No.
ABIN7173390
Quantity
100 μg
Datasheet
Datasheet
Reactivity
Human, Mouse
Application
IHC
Validations
- (1)
Cat. No.
ABIN7263873
Quantity
200 μL
Datasheet
Datasheet
Recommended TGS1 ELISA Kits
Product
Reactivity
Analytical Method
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Human
Analytical Method
Quantitative Sandwich ELISA
Validations
Cat. No.
ABIN6231527
Quantity
96 tests
Datasheet
Datasheet
Recommended TGS1 Proteins
Product
Reactivity
Source
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Human
Source
Wheat germ
Validations
- (1)
Cat. No.
ABIN1322650
Quantity
10 μg
Datasheet
Datasheet
Reactivity
Human
Source
Wheat germ
Validations
- (1)
Cat. No.
ABIN1322652
Quantity
25 μg
Datasheet
Datasheet
Reactivity
Human
Source
Tobacco (Nicotiana tabacum)
Validations
Cat. No.
ABIN3095924
Quantity
1 mg
Datasheet
Datasheet
Latest Publications for our TGS1 products
: "Large-scale characterization of HeLa cell nuclear phosphoproteins." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 101, Issue 33, pp. 12130-5, (2004) (PubMed).: "Different isoforms of PRIP-interacting protein with methyltransferase domain/trimethylguanosine synthase localizes to the cytoplasm and nucleus." in: Biochemical and biophysical research communications, Vol. 309, Issue 1, pp. 44-51, (2003) (PubMed).
: "Identification of a transcriptionally active peroxisome proliferator-activated receptor alpha -interacting cofactor complex in rat liver and characterization of PRIC285 as a coactivator." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 99, Issue 18, pp. 11836-41, (2002) (PubMed).
Synonyms and alternative names related to TGS1
trimethylguanosine synthase 1 (TGS1), trimethylguanosine synthase 1 (Tgs1), trimethylguanosine synthase 1 L homeolog (tgs1.L), D4Ertd800e, NCOA6IP, Ncoa6ip, PIMT, Pimt, PIPMTProtein level used designations for TGS1
- CLL-associated antigen KW-2
- PRIP-interacting protein PIPMT
- PRIP-interacting protein with methyltransferase domain
- PRIP-interacting protein with methyltransferase motif
- SEREX-defined
- cap-specific guanine-N2 methyltransferase
- hepatocellular carcinoma-associated antigen 137
- nuclear receptor coactivator 6 interacting protein
- nuclear receptor coactivator 6-interacting protein
- trimethylguanosine synthase
- trimethylguanosine synthase homolog
- PIPMT
- PIMT
- LOW QUALITY PROTEIN: trimethylguanosine synthase
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