TFEB Products
(Transcription Factor EB (TFEB))
Categories
Transcription factor that specifically recognizes and binds E-box sequences (3'-CANNTG-5'). Efficient DNA-binding requires dimerization with itself or with another MiT/TFE family member such as TFE3 or MITF. In association with TFE3, activates the expression of CD40L in T-cells, thereby playing a role in T- cell-dependent antibody responses in activated CD4(+) T-cells and thymus-dependent humoral immunity. Specifically recognizes and binds the CLEAR-box sequence (5'-GTCACGTGAC-3') present in the regulatory region of many lysosomal genes, leading to activate their expression. It thereby plays a central role in expression of lysosomal genes. Specifically recognizes the gamma-E3 box, a subset of E-boxes, present in the heavy-chain immunoglobulin enhancer. Plays a role in the signal transduction processes required for normal vascularization of the placenta.
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Featured TFEB Categories
TFEB Antibodies
High quality antibodies with extensive validation data.
TFEB Proteins
Proteins for various applications incl. WB, ELISA, IF etc.
Recommended TFEB Antibodies
Product
Reactivity
Application
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Human
Application
WB, ELISA, IF
Validations
- (1)
- (5)
Cat. No.
ABIN563503
Quantity
100 μg
Datasheet
Datasheet
Reactivity
Cow, Dog, Goat, Horse, Human, Rabbit
Application
WB
Validations
- (5)
Cat. No.
ABIN2787554
Quantity
100 μL
Datasheet
Datasheet
Reactivity
Human
Application
WB, ELISA, IHC, IF
Validations
- (3)
Cat. No.
ABIN7172536
Quantity
100 μg
Datasheet
Datasheet
Recommended TFEB ELISA Kits
Product
Reactivity
Analytical Method
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Human
Analytical Method
Semi-Quantitative DNA-Binding ELISA
Validations
- (2)
- (2)
Cat. No.
ABIN5526704
Quantity
96 tests
Datasheet
Datasheet
Recommended TFEB Proteins
Product
Reactivity
Source
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Human
Source
Escherichia coli (E. coli)
Validations
- (1)
Cat. No.
ABIN7125448
Quantity
50 μg
Datasheet
Datasheet
Reactivity
Human
Source
Wheat germ
Validations
- (1)
Cat. No.
ABIN1786750
Quantity
10 μg
Datasheet
Datasheet
Reactivity
Human
Source
Escherichia coli (E. coli)
Validations
- (1)
- (1)
Cat. No.
ABIN2733467
Quantity
50 μg
Datasheet
Datasheet
Latest Publications for our TFEB products
: "Lysosomal sequestration of weak base drugs, lysosomal biogenesis, and cell cycle alteration." in: Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie, Vol. 153, pp. 113328, (2022) (PubMed).: "Restoring autophagic flux attenuates cochlear spiral ganglion neuron degeneration by promoting TFEB nuclear translocation via inhibiting MTOR." in: Autophagy, Vol. 15, Issue 6, pp. 998-1016, (2019) (PubMed).
: "HSPA5 negatively regulates lysosomal activity through ubiquitination of MUL1 in head and neck cancer." in: Autophagy, Vol. 14, Issue 3, pp. 385-403, (2019) (PubMed).
: "MITA modulated autophagy flux promotes cell death in breast cancer cells." in: Cellular signalling, Vol. 35, pp. 73-83, (2018) (PubMed).
: "Altered Differentiation Potential of Gaucher's Disease iPSC Neuronal Progenitors due to Wnt/β-Catenin Downregulation." in: Stem cell reports, Vol. 9, Issue 6, pp. 1853-1867, (2017) (PubMed).
: "TFEB regulates PER3 expression via glucose-dependent effects on CLOCK/BMAL1." in: The international journal of biochemistry & cell biology, Vol. 78, pp. 31-42, (2017) (PubMed).
: "Mondo complexes regulate TFEB via TOR inhibition to promote longevity in response to gonadal signals." in: Nature communications, Vol. 7, pp. 10944, (2016) (PubMed).
: "A novel curcumin analog binds to and activates TFEB in vitro and in vivo independent of MTOR inhibition." in: Autophagy, Vol. 12, Issue 8, pp. 1372-89, (2016) (PubMed).
: "Neuraminidase of Influenza A Virus Binds Lysosome-Associated Membrane Proteins Directly and Induces Lysosome Rupture." in: Journal of virology, Vol. 89, Issue 20, pp. 10347-58, (2015) (PubMed).
: "Aberrant differentiation of Tsc2-deficient teratomas associated with activation of the mTORC1-TFE3 pathway." in: Oncology reports, Vol. 34, Issue 5, pp. 2251-8, (2015) (PubMed).
Synonyms and alternative names related to TFEB
transcription factor EB (TFEB), transcription factor EB (tfeb), transcription factor EB (Tfeb), alphatfeb, ALPHATFEB, BHLHE35, bHLHe35, MGC145796, tcfeb, TCFEB, Tcfeb, TFEBProtein level used designations for TFEB
- transcription factor EB
- transcription factor EB-like
- T-cell transcription factor EB
- class E basic helix-loop-helix protein 35
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