TERT Products
(Telomerase Reverse Transcriptase (TERT))
Categories
Telomerase is a ribonucleoprotein polymerase that maintains telomere ends by addition of the telomere repeat TTAGGG. The enzyme consists of a protein component with reverse transcriptase activity, encoded by this gene, and an RNA component which serves as a template for the telomere repeat. Telomerase expression plays a role in cellular senescence, as it is normally repressed in postnatal somatic cells resulting in progressive shortening of telomeres. Deregulation of telomerase expression in somatic cells may be involved in oncogenesis. Studies in mouse suggest that telomerase also participates in chromosomal repair, since de novo synthesis of telomere repeats may occur at double-stranded breaks. Alternatively spliced variants encoding different isoforms of telomerase reverse transcriptase have been identified\; the full-length sequence of some variants has not been determined. Alternative splicing at this locus is thought to be one mechanism of regulation of telomerase activity. [provided by RefSeq, Jul 2008].
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Featured TERT Categories
TERT Antibodies
High quality antibodies with extensive validation data.
TERT ELISA Kits
Reliable ELISA kits for a wide range of species.
TERT Proteins
Proteins for various applications incl. WB, ELISA, IF etc.
Recommended TERT Antibodies
Product
Reactivity
Application
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Human
Application
WB, ELISA, IHC, IF, IP, FM
Validations
- (46)
- (8)
Cat. No.
ABIN6655270
Quantity
100 μg
Datasheet
Datasheet
Reactivity
Human, Mouse, Rat
Application
WB, ELISA, FACS, IF (cc), IF (p), IHC (p), IHC (fro)
Validations
- (3)
- (5)
Cat. No.
ABIN726650
Quantity
100 μL
Datasheet
Datasheet
Reactivity
Human
Application
ELISA, IHC, FACS
Validations
- (6)
Cat. No.
ABIN5542472
Quantity
100 μL
Datasheet
Datasheet
Recommended TERT ELISA Kits
Product
Reactivity
Analytical Method
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Mouse
Analytical Method
Quantitative Sandwich ELISA
Validations
- (1)
- (1)
Cat. No.
ABIN6962962
Quantity
96 tests
Datasheet
Datasheet
Reactivity
Human
Analytical Method
Quantitative Sandwich ELISA
Validations
- (1)
- (1)
Cat. No.
ABIN6961943
Quantity
96 tests
Datasheet
Datasheet
Reactivity
Rat
Analytical Method
Quantitative Sandwich ELISA
Validations
- (3)
- (1)
Cat. No.
ABIN6959880
Quantity
96 tests
Datasheet
Datasheet
Recommended TERT Proteins
Product
Reactivity
Source
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Mouse
Source
Escherichia coli (E. coli)
Validations
- (1)
Cat. No.
ABIN7125334
Quantity
50 μg
Datasheet
Datasheet
Reactivity
Human
Source
Escherichia coli (E. coli)
Validations
Cat. No.
ABIN7396088
Quantity
100 μg
Datasheet
Datasheet
Reactivity
Mouse
Source
Escherichia coli (E. coli)
Validations
Cat. No.
ABIN7404335
Quantity
100 μg
Datasheet
Datasheet
Latest Publications for our TERT products
: "Evaluation of Some Prognostic Biomarkers in Human Papillomavirus-Related Multiphenotypic Sinonasal Carcinoma." in: Iranian journal of medical sciences, Vol. 49, Issue 3, pp. 156-166, (2024) (PubMed).: "Immortalized human choroid plexus endothelial cells enable an advanced endothelial-epithelial two-cell type in vitro model of the choroid plexus." in: iScience, Vol. 25, Issue 6, pp. 104383, (2022) (PubMed).
: "The clinical and functional effects of TERT variants in myelodysplastic syndrome." in: Blood, Vol. 138, Issue 10, pp. 898-911, (2021) (PubMed).
: "Telomerase therapy attenuates cardiotoxic effects of doxorubicin." in: Molecular therapy : the journal of the American Society of Gene Therapy, Vol. 29, Issue 4, pp. 1395-1410, (2021) (PubMed).
: "Neutrophils induce paracrine telomere dysfunction and senescence in ROS-dependent manner." in: The EMBO journal, Vol. 40, Issue 9, pp. e106048, (2021) (PubMed).
: "HIF-1α and Pro-Inflammatory Signaling Improves the Immunomodulatory Activity of MSC-Derived Extracellular Vesicles." in: International journal of molecular sciences, Vol. 22, Issue 7, (2021) (PubMed).
: "Extracellular vesicles from rat-bone-marrow mesenchymal stromal/stem cells improve tendon repair in rat Achilles tendon injury model in dose-dependent manner: A pilot study." in: PloS one, Vol. 15, Issue 3, pp. e0229914, (2020) (PubMed).
: "Telomerase promotes formation of a telomere protective complex in cancer cells." in: Science advances, Vol. 5, Issue 10, pp. eaav4409, (2020) (PubMed).
: "Inhibition of nucleotide synthesis promotes replicative senescence of human mammary epithelial cells." in: The Journal of biological chemistry, Vol. 294, Issue 27, pp. 10564-10578, (2020) (PubMed).
: "Maternal neglect results in reduced telomerase activity and increased oxidative load in rats." in: Stress (Amsterdam, Netherlands), pp. 1-5, (2020) (PubMed).
Synonyms and alternative names related to TERT
telomerase reverse transcriptase (TERT), Telomerase Reverse Transcriptase (trt-1), telomerase reverse transcriptase (Tert), telomerase reverse transcriptase (tert), Tertp (TERT), telomerase reverse transcriptase (CMU_003490), telomerase reverse transcriptase (VDBG_04487), Telomerase catalytic subunit (GL50803_16225), telomerase reverse transcriptase L homeolog (tert.L), ATTERT, chTERT, CMM9, DKCA2, DKCB4, EST2, est2, F5E19.190, F5E19_190, hEST2, hTRT, PFBMFT1, TCS1, tcs1, telomerase, telomerase reverse transcriptase, Tert, tert, tert-A, TP2, tp2, TR, TRT, trt, xTERTProtein level used designations for TERT
- telomerase catalytic subunit
- telomerase-associated protein 2
- Telomerase Reverse Transcriptase family member (trt-1)
- telomerase reverse transcriptase
- hypothetical protein
- telomerase reverse transcriptase beta
- Telomerase catalytic subunit
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